<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24637
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MKYEVDCIGPVYSHIFITSDFISTSLRLHLDLMPDPLDEIQWKSPEWIQQFGLHTGNVLDYFSESPFYDRTSNNQVLRMQFQFQAPPANIHPQRYIQDKLTEMTGIEFVIAYMREPDFWVIRKQNRTGPESTITEQDFYIIGANVYQAPKVYDLLSSRLLSSVLSIKTSVGLLNQMSKYSISDGGHVYPSVNDVERTRNSTHPTTSVAATGNGAGATPMKTPSVPASVPGTVPATVPGTIPGTGLLSSAQNEIFGMNPEVSVSAFSSLLAGAVSGNDSIYLDDVPTSGKGSTINQMNVRER |
Length | 301 |
Position | Head |
Organism | Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Meyerozyma.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.241 |
Instability index | 38.07 |
Isoelectric point | 5.22 |
Molecular weight | 33107.88 |
Publications | PubMed=19465905
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24637
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.76| 10| 127| 129| 157| 1
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115- 124 (20.20/17.08) EPDFWVIRKQ
135- 144 (18.56/27.45) EQDFYIIGAN
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|