Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLPRKKNDGFLSVPISRVSSTQRLNQLNTVSRPNSPSYISSSLNPSRNVPITPTNHDAKNDIPNFENVPIVATLTEFENQLDAFTASISSFKGDQLADSMSQLVQLNDTLKQELESLKTHQELGKRIGQLKQQNLELDTKAKQMLRELISCRAELRKMPRLSSKGDDKESQNKEIDVKEALKYAMKLAKFTRAPPMVGNAQFQIHPNNFIWPAEDSLRRGMLALSSLKPEELIKQELGTAENSEAEQTMAEEHNEPEEDIIQSFDNNESKGNAAPLSLDLFDSEEDSD |
Length | 288 |
Position | Middle |
Organism | Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Meyerozyma. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.749 |
Instability index | 53.39 |
Isoelectric point | 5.04 |
Molecular weight | 32338.84 |
Publications | PubMed=19465905 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP24628 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 67.66| 20| 24| 208| 231| 1 --------------------------------------------------------------------------- 212- 231 (33.46/25.80) PAEDSLRRGMLALSSLKPEE 239- 258 (34.20/15.01) TAENSEAEQTMAEEHNEPEE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 75.02| 24| 24| 82| 105| 2 --------------------------------------------------------------------------- 82- 105 (39.75/31.01) DAFTASISSFKGDQ.LADSMSQLVQ 108- 132 (35.28/26.69) DTLKQELESLKTHQeLGKRIGQLKQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 34.58| 10| 16| 45| 54| 3 --------------------------------------------------------------------------- 45- 54 (20.43/13.00) PS.RNVPITPT 63- 73 (14.15/ 6.93) PNfENVPIVAT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GFLSVPI 2) MLPRKK 3) QTMAEEHNEPEEDIIQSFDNNESKGNAAPLSLDLFDSEEDSD | 9 1 247 | 15 6 288 |
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