<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24621

Description "Aspergillus niger contig An11c0340, genomic contig"
SequenceMIPHSSAGVQPWGRSLRALNNGSGRVDASQALVQSDPQLEKLSMSMPQPLPRQPAVIDLTANASDSQDREPPAKRLKLDAPPGSCPPEGSPAPGSGGEARSTPGTASSKPNPLAWRGRPVWSFQALISETTGAVEAKEDDTTSQGKNPASPPPLPLVPWKHTPQEASGSNSAKANVASTKEVQTTPYRIVVPPVAPKLKGERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHSTIATPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKGIPVPRAIWLARCVGANEIRAFKRKGTSGTLALGLETKWVRDWTSTVQQFLESVIGTCGSSDWKTKMTYAVSLTSRLFFERLLDHDQYLSWFLASLEAAPLNTVPVWLLMLGIYWNNIMRYRKRGRRLAEVLLEKLRLIKQPGQSTALEPLVERLSRWIRRLVLEHTSSVILPKSWDKYKDLIASCLNLKESPDKTTLQNLAERNVRVQLPTNHQVTTQQLPQQHVIHLFESIQSAHDVLSTSSACLAAVEDKATLVAKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGMDVESHILAFLANIQITSRVNMDNVYHIIAELVRSQTFSVGRYLQWLMAKGVANDPLPDQHKAISDDLRLLIQLPLARLPEYVRNLRNTLLSRAGITASDEESTIATVKASIAQRLPKIFGPQASDAMLTDQPLSSLTWAVKSEIGLWIRRGVSGHCREPVRKYAHIPMLADSGVSALTPVEFYNIRDVLESFGDISMLADVLKQATNCDDSVVLASVADTINLHFDSLSIIGAATDLFKGLVESYARLKRLGAPSLDLIFSLIELGLRMPSEFNTVALLRQDLSRIENKSALAAPSPLSDNLSTAFNDADSSFQEKLDQILFSGGGMDESSMDSIFNSLTAALANENGHLKLSANDICRYLAYLRSFHPKRFDARLVRWVCGVLKSPSRIAMVRILPPLIGVGCVTIHAFVMLVKKLLQSERVASVVPKVTDLQLDLLELLVSQESSGSRYTDMVTYRYYLAQQEFIDKHPEECLNIIRAAVPLINMRQTESASESNPADLTKCAMVLLQTLLTQKPERMVQCCTQKLVGQDPASTMILQEALDALLGFNSQDPQTMSEAERVIGMNNDFSLPICQLKLQLLFNAEAGNGVDNGIVDVMFKAAMADARSKRSHWYGLVSLMNQDAVRQIRERAEKGFFSIPILEEPIGDPTVADKSNSIETARLYLAIIEKLAYSIPETGVPSVAPMLVEKMELLLQKFITMQPNPSAPAESCQIAQARSNFERSLAFWFSALLRLVVLHRSAFNTSALTPKPIGLQEQARMLISIFCITLARLPDRVIRLYPSANYFPHPVQSEGYRPCPGILLQTHALDVAAALIDTFPDEARQQCASFLKEKCPPFLQFQNDSRFLYLLGPVMDTSTLNSSQPASLPSPAAGGSTPTPTGNLAGGPPNSQQNLSSASGLPAGLSEGVNCIASHLRLQYRGRVLGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1584
PositionKinase
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy-0.172
Instability index50.13
Isoelectric point8.93
Molecular weight174672.59
Publications
PubMed=17259976

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24621
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.95|      41|      68|    1025|    1066|       1
---------------------------------------------------------------------------
 1025- 1066 (61.46/42.27)	CVT.IHAFVMLVkKLLQSERVASVVP.KVTDLQLDLLELLVSQE
 1095- 1137 (60.49/37.16)	CLNiIRAAVPLI.NMRQTESASESNPaDLTKCAMVLLQTLLTQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.29|      54|      67|      48|     111|       2
---------------------------------------------------------------------------
   48-  111 (85.84/59.66)	QPLPRQPAVIDLTANASDSQDREPPAKrlkldappGSCPpeGSPAPGSGGEARSTP....GTASSKPN
  118-  175 (92.45/45.40)	RPVWSFQALISETTGAVEAKEDDTTSQ........GKNP..ASPPPLPLVPWKHTPqeasGSNSAKAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.54|      42|      67|    1283|    1327|       3
---------------------------------------------------------------------------
 1283- 1327 (65.64/46.53)	ARLYLAIIEKLAYSipeTGVPSVAPM.LVEKMELLLQKF.ITMQPNP
 1353- 1396 (61.90/36.09)	ALLRLVVLHRSAFN...TSALTPKPIgLQEQARMLISIFcITLARLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.68|      33|     152|     490|     526|       6
---------------------------------------------------------------------------
  490-  524 (49.03/45.27)	IRRL..VLeHTSSVILPKSWDKyKDLIASCLNLKESP
  564-  598 (49.65/28.40)	IQSAhdVL.STSSACLAAVEDK.ATLVAKLLEWAATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.01|      23|     407|     334|     360|       8
---------------------------------------------------------------------------
  334-  360 (36.29/30.81)	PVPRAIWLARcvgaNEIRAFKRKGTSG
  753-  775 (41.71/24.31)	PLSSLTWAVK....SEIGLWIRRGVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.58|      41|    1131|     379|     432|      17
---------------------------------------------------------------------------
  226-  278 (56.59/28.40)	GHYD.RTQVSQNESNTARPSLYAQLKHRsglQMLsSVFAAALEkrqshstiATP
  390-  431 (68.99/45.46)	GSSDwKTKMTYAVSLTSRLFFERLLDHD...QYL.SWFLASLE........AAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24621 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQL
2) LNSSQPASLPSPAAGGSTPTPTGNLAGGPPNSQQNLSSAS
3) MIPHSSAGVQPWGRSLRALNNGSGRVDASQALVQSDPQLEKLSMSMPQPLPRQPAVIDLTANASDSQDREPPAKRLKLDAPPGSCPPEGSPAPGSGGEARSTPGTASSKPNPLAWRGRPVWS
4) QALISETTGAVEAKEDDTTSQGKNPASPPPLPLVPWKHTPQEASGSNSAKANVASTKEVQTTPYRIVVPPVAPK
200
1482
1
124
249
1521
122
197










Molecular Recognition Features






MoRF SequenceStartStop




1) PAKRLKL
72
78