<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24618

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTHQIIIAPPRRRASTQIRHLARLASPLVLTPNAPPSRSRPLPPPSLRRVVQSPPSARKSLPDASISPSRSLAARPRTSPYPPSSSRRPPPPPPAPRTTAPGVSPRSPTSSARASAPPRPASPSSSSSRLRVASPSSSRPFQTARRRRRRPSRSASSSRASTGAMPTRAVRRARRANRAARIAPRVGVARRSGVARRARCRRESVSVWCATREGFCLTRNNGLGSPNADRRATRPRTDARGMETLPKRAPATTLADVVERVARACHVELRQLVERCAGADARARAAELARYAHRARQRLVRCAIVERWSRKSAKIATVATNAHLTLRAHEEAFAKLADGLFHLHQQIEWAKAPAWDLAGALNVLCDGDYELGREISEIGVGRVAATEETEETEETRERRLDFERRFEEEMTERLVRSKTHGCATRDDHSEWPNEKFKVFAIGGGKVEVGVEGEYRATLSLGGPVAPNATEQPRYGGWRVETIEMLAGDEKGAKFELNKAETRKLADMACASMVGLPPFGQKLADDAPPLEPLHLKGLHGVASDAVLLKSAAAILAQAGALKDAAERANSESRWSRNAVKVEIVKGEAAGILKGVRVAFWRQNVASADEAGMLDVSFNPETADLRAKARAPGEAEFFDLPVNYARVDLEAILVEAIRIASSKKLHSVSTEVSGEKSFTTVVEESMTAEECACSEDEDAWGTDARPAIRLEISKFTNIFITCRISDGTLILHGAGELVPSATEADLSKRLALEGHDAIVSIVEEVSVAVEQQELKGLLRTSGTSVHPAPKTLGGEPWSTSDAVPSGVAPTALVPVVPSDGGVFVATWMGATPTFALVRAHRVNPASRYIAHSVEKLNLGARKGSKADVVVKMIGEACRDLSVDAQRSALMRALKEQRVPFVDIRPTSKGTKKAANTVSFEIVNTSRWAQSKYKRAIKQKSPLKAHVTLRGIDGLSASIGGETRAYEHSEFMIHAFLADVRRIAAAQGFLSALSDNDSGVDFAKLGCKLSRQAADVVSISYKDSIECTIEWRHSGYLGPGLYADGERLSSSAKRALSVAARDGRCEIFACALRAVEAAASHFAQLHGDFQLTFGAPSVLSIVRIIGVSAMRVCSIGFRLDGSVSFVVGRGGDGAHDDGSTNDDEMNITDDHEALIPTRPEGLTQYIDEISAALEGPLGSKPKHGDAVVANASSASPALAALAKSVVAK
Length1205
PositionTail
OrganismOstreococcus lucimarinus (strain CCE9901)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> Mamiellophyceae> Mamiellales> Bathycoccaceae> Ostreococcus> unclassified Ostreococcus.
Aromaticity0.05
Grand average of hydropathy-0.317
Instability index54.31
Isoelectric point9.63
Molecular weight129562.50
Publications
PubMed=17460045

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.56|      21|      25|      76|      96|       1
---------------------------------------------------------------------------
   37-   57 (31.77/12.62)	SRSRPLPPPSLRR..VVQSPPSA
   76-   96 (45.67/21.76)	PRTSPYPPSSSRR..PPPPPPAP
  101-  123 (32.60/13.16)	PGVSPRSPTSSARasAPPRPASP
  130-  146 (25.52/ 8.51)	LRVA..SPSSSR....PFQTARR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.44|      12|      15|     170|     181|       2
---------------------------------------------------------------------------
  170-  181 (21.63/ 7.33)	VRRARRANRAAR
  229-  240 (20.82/ 6.79)	DRRATRPRTDAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.88|      26|      95|     189|     215|       3
---------------------------------------------------------------------------
  189-  215 (42.33/26.80)	ARRSGVARRARCRRESVsVWCATREGF
  283-  308 (43.55/23.50)	ARAAELARYAHRARQRL.VRCAIVERW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     337.03|      93|      95|     397|     491|       4
---------------------------------------------------------------------------
  330-  389 (59.92/25.38)	......................................EEAFAKLADGLFHLHQQIEWAKAPAWDLAG..ALNVLCDGDYElGREISE..IGVgrVAATEET
  397-  491 (148.01/79.43)	ERRLD..FERRFEEEMTERLVRSKTHGCATRDDHSewPNEKFKVFAIGGGKVEVGVEGEYRATLSLGGPVAPNATEQPRYG.GWRVET..IEM..LAGDEKG
  493-  589 (129.10/63.56)	KFELNkaETRKLADMACASMVGLPPFGQKLADDAP..PLEPLHLKGLHGVASDAVLLKSAAAILAQAGALKDAAERANSES.RWSRNAvkVEI..VKGEAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     381.35|     127|     253|     742|     877|       5
---------------------------------------------------------------------------
  742-  877 (190.27/112.74)	ADLSKRLALEGHDAI.VSIVEEVSVAVEQQElKGLLrtsGTSVHPAPKTLGGEPWST.SDAVPSG...VAPTALvPVVPSDGGVFvATWMGatpTFALV.RAHRVNPASRYIAHSVEKL.NLGARKGSKADVVVKMIGEACRD
 1000- 1133 (191.08/92.72)	AKLGCKLSRQAADVVsISYKDSIECTIEWRH.SGYL...GPGLYADGERLSSSAKRAlSVAARDGrceIFACAL.RAVEAAASHF.AQLHG...DFQLTfGAPSVLSIVRIIGVSAMRVcSIGFRLDGSVSFVVGRGGDGAHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24618 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTHQIIIAPPRRRASTQIRHLARLASPLVLTPNAPPSRSRPLPPPSLRRVVQSPPSARKSLPDASISPSRSLAARPRTSPYPPSSSRRPPPPPPAPRTTAPGVSPRSPTSSARASAPPRPASPSSSSSRLRVASPSSSRPFQTARRRRRRPSRSASSSRASTGAMPTRAVRRARRANRAARIAPRVGVARRSGVAR
2) NNGLGSPNADRRATRPRTDARGMETLPKRAP
1
220
196
250










Molecular Recognition Features






MoRF SequenceStartStop




1) KSVVAK
2) MTHQIIIA
3) QIRHLARLASPLVL
1200
1
17
1205
8
30