<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24582

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRAIVASNLASQDGFSHIYWRIYTDDPGESPTNGYAILKHLSRLKDLELQLRDRNCLVSSYPRRLCLWVFSATPGFESLSPLSPNNGKDDSGRLAIGSATLKVSSSGNVSSLELVKNLSTETQNAPGAAGSQRPNAITPFATIYASFISAVSGAVSLQLIRQRNAIPLGSRTLFTVVEKDGCDNSHVTENDVVLAPSLTTLQVQLTSAGKLTVALQTVSQAGLTRLLIPEDDPAGIHDTPPGTDLWLSPSGSIARLVAANPSRLNAASPYPSNVGGPGNEKSSPATRKQWKVNVLWWLSNFGLPVDGIDDEAWVEVEVWEPFYSRLAGEVWRPNDEGASVLPLKRILWPAIYCFRRTKSASSEFYGEMEGVSSIAGDPLDFAEKWRVTEKLSFAEASPKPPSVHQEPPTRDQDASSPDLLNLPEGIESLSRASQYPDLQTASLVYPTPPDGATATGLNPMVTSDTFAEEIEQNSNFMQQDRQNHHRQLSKERIGTDVISFGPSAGLVVGSGLYDTNDDDDLFGEINEKDFGAKGITDADFSFFDDPDFDRGGVGEQAEPVQELSGFMDTDEPEIQPTVDSQASPEHTPAMNIASAQLSPVVETADLQHEKTPQEAKAPVFTPQEDKPRTISPPLSPVEVKKILFPESVPESPRLAKKGQGPGYYSAVAFKQNMSLWDQKYGADGKFGFNIRGIERKKGPDTVTSDIPTVGLPRHSGKVKSGTSKDPDSYGSPYSEEMQDSSSDSDMSSSASADSDESASESGLSPATFSTRKRKRTRSNSGTSLALSQDKTIIRTDQETSAQRPEDSVFLGNFLSTFSDWSMAGYFSVAQNQVSPLLIRKDIQVQIAQLLVDQVTQSSLHHRIDGTLGLLDYADQGCSPETFRGDAAFMSGMERLDLNSFVSLQDSNALSPSSSNGSNSRQSAQRRETGKGTIVKIPPPHLRVRRGKDFLETLPPAISFWETFGLEPAHGQKDILAYCIHPHFAAGAADTFLERLGLVYSGCNLGEHCRGESSNVFDRGLGSWNTSPSADSRYSEAIQSLKSICGVLGSAFLSTPPSKDSNIVVYIVNPFTHAAALVDICAAFWSLFQQYVAEADKQQTRQLNELVLQIIPLDFVTSAESLVVPPQAEYLNLALEVYSRCPPKSSEVGPVNCAPPVLLAEPIPRSIGFKLSSEGSSPLQEGKHLHIACSRSLDQRWLSVAWSDNFGALQRNMSYCLRYRNSVAARPLPEVRGEIWKATRDIMDTIQTRWKIIIVSTDPVDQDEVDTWTNFADQYGKARSTTLDLAILGANIPSDLHLEPPYLPIPLSMFNQQPSSTPVATPNLGGGVSSPDQFGTAPTPPGGWGGPASASTPTDALPEVESESLLTDIYDETWGVVLSHRLNSSPHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILFARRSPSSYDALLREILGLFWIWTGRNC
Length1457
PositionKinase
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.08
Grand average of hydropathy-0.374
Instability index51.12
Isoelectric point4.96
Molecular weight158379.77
Publications
PubMed=17259976

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24582
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     421.91|     161|     538|     417|     684|       1
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   34-  129 (108.66/27.87)	......................................................................................TDDPGESPT.NGYAILKHLSRLKDLELQL....RDRNCLVSSYPRRLCLWVFsaTPGFE...SLS.PLSPNNGKD........DSGRLAigsatLKVSSSGNVSSLELVKNLS
  496-  684 (237.30/168.17)	RQLSKERiGTD.VISFGPSAGLVVGSGLY..DTNDDDDLFGEINEKDFGAKGiTDADFSFFDDPDFDRGGVGEQAEPvqelsgfmdTDEPEIQPTvDSQASPEHTPAMNIASAQLspvvETADLQHEKTPQEAKAPVF..TPQEDkprTISpPLSPVEVKKilfpesvpESPRLA.....KKGQGPGYYSAVAFKQNMS
  701-  775 (75.94/ 7.55)	RGIERKK.GPDtVTSDIPTVGLPRHSGKVksGTSKDPDSYGSPYSEEMQDSS.SDSDMSSSASADSDESASESGLSP..........................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.81|      50|     172|     243|     294|       2
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  243-  294 (85.79/48.89)	PAGIHDTPP.......GTDLWLSPSGsIARLVAAN..PSrLNAAS.PYPSNVGGPGNEKSSP
  410-  469 (79.02/37.87)	PPSVHQEPPtrdqdasSPDLLNLPEG.IESLSRASqyPD.LQTASlVYPTPPDGATATGLNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.86|      50|     126|    1209|    1263|       3
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 1209- 1263 (84.82/48.67)	VAWSDNFGALQ.RNMSYCLRYRNSVAARPLPEVRGEIWkatrdIMDTIQTRWKIII
 1337- 1387 (85.03/40.57)	VSSPDQFGTAPtPPGGWGGPASASTPTDALPEVESESL.....LTDIYDETWGVVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.07|      56|     355|    1034|    1094|       4
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 1034- 1094 (87.14/62.33)	NTSPSaDSRYSEAIQS...LKSICGVLGSAFLSTppskDSNIVVYIVNPFTHAAALVDICAAFW
 1392- 1450 (92.93/53.10)	NSSPH.QTEYRPALASgylLRRKGSTDGDGLYTM....SVNILFARRSPSSYDALLREILGLFW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.73|      40|     666|     306|     347|       9
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  306-  347 (71.45/46.34)	WWlSNFGL.PVDGIDD......EAWVEVEVWEPFYSRLaGEVWRPNDEG
  969- 1015 (65.28/34.81)	FW.ETFGLePAHGQKDilayciHPHFAAGAADTFLERL.GLVYSGCNLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.18|      34|     613|     202|     241|      12
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  202-  241 (45.29/45.17)	VVLAPSLTTLQvQLTSAGKLTVALQTVSqagltRLLIPED
  818-  851 (61.89/41.88)	VFLGNFLSTFS.DWSMAGYFSVAQNQVS.....PLLIRKD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24582 with Med13 domain of Kingdom Fungi
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