<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24580

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDSINVGDLFGEPTSLELGLPPSASPARGLAQRLDEMRLLGCCQKIAWSKLGCIAYISQDSLRVKVRHLQCRPSDGKWVLSDETPLMPITEAHGGHALTHLSWNEAGSDLAVVDVTGRVSVYHIPFALNSVNGLRQPAFSPDDGSQIVGMMWLNTQRSVHAFYQAAKVQGRWAYSPFRRRPIGPFHPANKAALLCITRSGSMKLLYQNPDGRWDDISVDLKSTSYSDRLLSHAALVATQNGILVATYSINWNPPQWDPAQQPKQTPPQFPVPSFRFTHSKVETSCTVPGMHRNDGEEPDMMHQSISNPLYTLSRLDIILPASDNAAGTTANPWIVAVFSTPPQATPDHPGPQGPASVIVRWQLDTAAFTLHPKFDEMAAKRNSTQIKPRPVLRRLEDIYSDRYVISVDQIEYGNVVAITYDDSSVSFYDPKTMALFNGVDDANTVTGLAQAGFHYAPDASGCQGQHVSFSPSACAAVMLDSDGQTHLRVMEHSYGAENGLYDENAQITFINEVYRALPINCNFTVEQEKLMNHPYIPKCLSIQAALGFADKYKPRSFASSVSWSILQLRHAAILYPFFFQYNKGIQAEPHDPVKTTNSLALIILLSSMSRAFLRFICRGLRGIHAGYTNASLGGDSRLQYAEICQALDATPARIDVYEKFLSAVDSAVRHAYHGAGFGDTERPGPEKELLVNARIPPVLVAAVSTILRQTVPGLKSEVDRMAIYMHDYSWLGFGSDLRSELYRRTREVDIIKKTPIRMTIAQGSNGPQLGKPNNQGVLRRRCVRCCDVSEGTYPPRSVLAFRMIFKLGHLRSCICGGMWTLESGLNEVGK
Length835
PositionTail
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.09
Grand average of hydropathy-0.226
Instability index46.71
Isoelectric point7.84
Molecular weight92342.19
Publications
PubMed=17259976

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24580
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.40|      37|      39|     552|     590|       1
---------------------------------------------------------------------------
  554-  590 (64.72/42.14)	ADKYKPRSFASSVSWSILQLRHAAILYPFFFQYNKGI
  592-  628 (61.68/33.38)	AEPHDPVKTTNSLALIILLSSMSRAFLRFICRGLRGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     369.84|      86|      91|     195|     285|       2
---------------------------------------------------------------------------
   91-  161 (58.55/27.68)	.................................LMPITEAhGGHALTHL..............S........WNEAGSDLAVVD.............VTGRVsV..YHIPFaLNSVNGLRQPAF...SpddgsqivgMMWLNTQ
  177-  260 (130.24/76.87)	W..AYSPFRRRP....IGPFhPA......nkaaLLCITRS.GSMKLLYQ..............N....PDGRWDDISVDLKSTS.............YSDRL.L..SHAAL.VATQNGILVATY...S.........INWNPPQ
  261-  348 (99.04/56.46)	WDPAQQPKQTPP....QFPV.PSFRFT.H....................skvetsctvpgmhrNdgeePDMMHQSISNPLYTLS.............RLDII.LpaSDNAA.GTTANPWIVAVF...S............TPPQ
  349-  436 (82.01/43.43)	ATPDHPGPQGPAsvivRWQL.DTAAFTlH.......................................P..KFDEMAAKRNSTQikprpvlrrlediYSDRY.V..ISVDQ.IEYGN.VVAITYddsS.........VSFYDPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.04|      44|     417|      29|      73|       3
---------------------------------------------------------------------------
   29-   73 (76.07/53.09)	ASPARGLAQRLDEM..RLLGC.CQKIAWSKLGCIAYI....SQDSLRVkVRH
  447-  497 (66.98/42.01)	ANTVTGLAQAGFHYapDASGCqGQHVSFSPSACAAVMldsdGQTHLRV.MEH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24580 with Med16 domain of Kingdom Fungi
Unable to open file!