Description | Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MPITGVYFIPSNPNASTGLATITERLHTALADEPTLVGRWFLEHRLMRDTPSCVPASASQRQVQPRYMQFLSLSFHSNHGFIYTSEALEKSTHHSTTSVSTTPAGSPTNSTAQSGAPGATAPTPSTPSNAAAQSGGPMVMTTVPLPSCNALFQHFGYACQPFWCHRHTVTVPGGVVYDVGDFRVRVGDVRQTQPAARVRGTVVEIEWRGPCIVDAISAPRNSSDGQIADDGDSGIDMAFPDAIEDADIDAEYAAIAALIREFWARLGIEGAREAILLPDVGKEAKDRLRRLKQKGRNTVSNEASLQQAEEDPDPDAGVDVARQFMEIFRFNR |
Length | 332 |
Position | Head |
Organism | Aspergillus niger (strain CBS 513.88 / FGSC A1513) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.318 |
Instability index | 41.55 |
Isoelectric point | 5.48 |
Molecular weight | 35951.77 |
Publications | PubMed=17259976 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP24579 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 126.09| 35| 94| 10| 53| 1 --------------------------------------------------------------------------- 10- 44 (60.69/28.84) PSNPNASTG....LATITERLHTALADEPTLVGRWFLEH 127- 165 (65.41/32.00) PSNAAAQSGgpmvMTTVPLPSCNALFQHFGYACQPFWCH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KDRLRRLKQKGR 2) QFMEIFRFNR | 285 323 | 296 332 |
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