<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24574

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGT
Length798
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index60.00
Isoelectric point9.16
Molecular weight87374.60
Publications
PubMed=19468303
PubMed=21183079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24574
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     212.01|      34|      37|     418|     451|       1
---------------------------------------------------------------------------
  351-  375 (35.89/11.17)	....P......PS....PIG.GDMMDSLISQLQPP..QQQPF
  398-  431 (57.03/21.95)	VNQSP......SMMHTQSPGNLHAASSPSGALRAP..SPASF
  432-  465 (64.37/25.69)	VPTPP......PSSHGISIGPGASFASPHGTLDPS..SPYTM
  466-  497 (26.04/ 6.15)	V.SPSgragnwPGSPQVS.GP.......SPATRLPgmSPAN.
  498-  519 (28.69/ 7.50)	.P..........SLH..SPVPDVSHS.....PRAG..TSSQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     212.40|      60|     503|     229|     288|       2
---------------------------------------------------------------------------
  229-  288 (103.89/60.28)	TPNVVQLLQVLF..........DTQAPLNAINKLPTVPML..GLTQRTNTAYQCFSIL..PQSSTHIRLAFRNM
  685-  712 (26.92/10.18)	..............................IMKLELFPDQ..ATQLKWNVQF.CLTIP..PSA...........
  720-  791 (81.58/45.75)	TPAVVLKSKMLFflqltqktsvPPQEPVSII..VPIIYDMasGTTQQADIPRQQNSSVaaPMMVSNILKRFAEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|     613|     627|       5
---------------------------------------------------------------------------
  613-  627 (21.47/14.99)	LKCRVALSP.KTNqTL
  651-  665 (22.14/10.62)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.62|      35|      44|     525|     561|       6
---------------------------------------------------------------------------
  525-  561 (57.66/43.77)	PPPRKLPQRSWAASIPTILTHSALNilLLPSPTPGLV
  572-  606 (58.96/38.48)	PLERFLGSVIMRRHLQRIIQQETLQ..LINSNEPGVI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24574 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWA
337
536










Molecular Recognition Features






MoRF SequenceStartStop




1) ILKRFAE
784
790