<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24571

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2182
PositionKinase
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index57.38
Isoelectric point6.78
Molecular weight243533.32
Publications
PubMed=19468303
PubMed=21183079
PubMed=23806337
PubMed=24129315

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24571
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     181.15|      15|      15|    2056|    2070|       1
---------------------------------------------------------------------------
 2056- 2070 (35.38/12.61)	QQQ.QQQQQQ.QQQQQQ
 2073- 2087 (35.38/12.61)	QQQ.QQQQQQ.QQQQQQ
 2088- 2103 (24.52/ 6.69)	QYHiRQQQQQ.QQMLRQ
 2104- 2117 (33.48/11.57)	QQQ.QQQQQQ.QQQQ.Q
 2118- 2132 (29.05/ 9.16)	QQQ.QPHQQQ.QQAAPP
 2133- 2148 (23.34/ 6.04)	QPQ.PQSQPQfQRQGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     329.93|     109|     345|     209|     346|       2
---------------------------------------------------------------------------
  217-  336 (166.42/159.17)	GSTIGPLPHDVEM....AIRQWDYNEKLalfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvIAAQSTSSlPTTPAPQ
  451-  568 (163.51/90.70)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..VASGSLSA.PSAPIFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.90|      42|     345|     661|     705|       3
---------------------------------------------------------------------------
  587-  635 (61.09/28.38)	SESERVEFFNLVlLFCELIRHDvFShnMYTCTLISRGDlafGAPGPRPP
  664-  705 (79.81/42.87)	SESMDIDPSSSV.LFEDMEKPD.FS..LFSPTMPCEGK...GSPSPEKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     121.78|      20|      20|    1745|    1764|       4
---------------------------------------------------------------------------
 1745- 1764 (37.06/14.79)	PLPPEDE..EP.....PA..PALLEPEKK
 1766- 1787 (27.84/ 9.30)	PEPPKTD..KP.....GAapPSTEERKKK
 1805- 1828 (27.27/ 8.96)	GMGPGRS..GPygvtvP...PDLLHHANP
 1849- 1869 (29.61/10.36)	PLPAGGPrvDP.....YR..PVRL.PMQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     335.70|      77|     235|    1143|    1219|       5
---------------------------------------------------------------------------
 1143- 1219 (126.26/70.45)	LLEDLIRCAAIPSLLNAACSEQDSE.PGARLTCRILLHLFKT.P.QLNPCQSDG...NKP...............TVG.IR.SSCD...RHLL.AA..SQNRIVDG
 1221- 1291 (40.52/17.03)	..........VFAVLKAVFVLGDAElKGSGFT..VPGGTEEL.PeEEGGGGSSG...RRQ............ggrNIS.VEtASLDvyaKYVL.RSicQQE.....
 1295- 1378 (82.26/43.04)	..E...RC..LKSLCEDSNDLQDPV.LSSAQAQR.LMQLICY.P.HRLLDNEDG...ENPqrqrikrilknldqwTMR..Q.SSLE...LQLMiKQ..TPNTEMNS
 1379- 1455 (86.65/45.78)	LLENIAK.ATIEVFQQSA..ETGSS.SGS..TASNMPSSSKTkP.VLSSLERSGvwlVAP...............LIAkLP.TSVQ...GHVL.KA..AGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     854|     868|       6
---------------------------------------------------------------------------
  854-  868 (26.85/18.00)	LEQITSFALG.MSYHL
  870-  885 (23.14/14.41)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.65|       9|      16|    1672|    1682|       9
---------------------------------------------------------------------------
 1672- 1682 (12.13/13.52)	IFkkEGLQVST
 1691- 1699 (17.52/10.58)	LF..EGLKPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.07|      38|      76|    1892|    1929|      10
---------------------------------------------------------------------------
 1892- 1929 (68.08/30.71)	PS.SY...K.......TSVY.RQ...QQPTVPQGQRLR.....QQLQAK.IQS.QGMLGQ
 1937- 1991 (40.59/15.22)	PSsSY...GlqtsqgyTSYV.SHvglQQHTGPAGTMVPpsyssQPYQST.HPStNPTLVD
 1992- 2033 (47.40/19.06)	PT.RHlqqR.......PSGYvHQ...QAPTYGHGLTST.....QRFSHQtLQQ.TPMMG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      17|    1028|    1040|      14
---------------------------------------------------------------------------
 1028- 1040 (25.11/16.44)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/12.44)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.51|      16|      18|     347|     364|      15
---------------------------------------------------------------------------
  347-  364 (26.01/20.46)	FSDLLM.CPQhrPLVFGLS
  367-  383 (26.49/13.45)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24571 with Med12 domain of Kingdom Metazoa
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