<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24570

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2157
PositionKinase
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.506
Instability index57.26
Isoelectric point6.77
Molecular weight240874.43
Publications
PubMed=19468303
PubMed=21183079
PubMed=23806337
PubMed=24129315

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     178.86|      15|      15|    2031|    2045|       1
---------------------------------------------------------------------------
 2031- 2045 (35.18/14.42)	QQQQQQQ.QQQQQQQQ
 2047- 2061 (35.18/14.42)	QQQQQQQ.QQQQQQQQ
 2068- 2083 (28.17/10.03)	QQQQQQQmLRQQQQQQ
 2084- 2098 (33.27/13.22)	QQQQQQQ.QQQQQQPH
 2099- 2112 (23.23/ 6.94)	QQQQQAA.PPQPQPQ.
 2126- 2140 (23.83/ 7.32)	QQQQQTA.ALVRQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.23|      15|     612|      21|      35|       2
---------------------------------------------------------------------------
   21-   35 (31.21/16.34)	PPDVY..P.QDPKQKEDE
  634-  651 (22.02/ 9.14)	PPSPFddPtDDPERKEAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.54|      55|     345|     209|     267|       3
---------------------------------------------------------------------------
  209-  267 (94.17/83.27)	GPAGSGGCGSTIGPLPHDVEMairQWdYNEKLALFMFQDGMLDRHEFLTWVLECFEKIR
  552-  606 (93.37/68.65)	GSVASGSLSAPSAPIFQDVLL...QF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.22|      38|     345|     661|     705|       4
---------------------------------------------------------------------------
  661-  705 (54.63/45.59)	PglSESmDIDPSSSVLFEDMEKPDFSLFSPTmpceGKGSPSPEKP
 1011- 1048 (70.58/36.56)	P..SES.NMRWAPEFMIDTLENPAAHTFTYT....GLGKSLSENP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.09|      20|      20|    1745|    1764|       5
---------------------------------------------------------------------------
 1745- 1761 (27.19/10.69)	....PLPPEDEEPPA..PAL......LEP
 1762- 1784 (27.23/10.72)	EKKaPEPPKTDKPGAapPST......EER
 1867- 1892 (20.67/ 6.29)	MQKlPTRPTY..PGV.lPTTmstvmgLEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     445.92|     121|     145|    1180|    1324|       6
---------------------------------------------------------------------------
  739-  834 (124.32/65.06)	FPIPQEESCSHECNQRLVvlfGVGKQRDdaRH..........................AIKKITKDILKV.LNRKGTAETDQ..LAPI...VPLNP.....................................GDLTFLGGED.GQKRRRN..R..PEAFPTAE.DIFAKF...................
 1181- 1301 (206.99/158.63)	FKTPQLNPCQSDGNKPTV...GIRSSCD..RHLLAASQ..................NRIVDGAVFAVLKA.VFVLGDAELKG..SGFT...VPGGT.....................................EELPEEEGGG.GSSGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSL
 1328- 1504 (114.61/58.58)	...PHRLLDNEDGENPQ......RQRIK..RILKNLDQwtmrqsslelqlmikqtpNTEMNSLLENIAKAtIEVFQQSAETGssSGSTasnMPSSSktkpvlsslersgvwlvapliaklptsvqghvlkaagEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      84.85|      13|     123|    1992|    2004|       7
---------------------------------------------------------------------------
 1971- 1983 (20.49/ 8.87)	LQQRPSGYVHQQA
 1992- 2004 (23.05/11.18)	STQRFSHQTLQQT
 2009- 2021 (17.81/ 6.44)	TMTPLSAQGVQAG
 2113- 2125 (23.51/11.60)	SQPQFQRQGLQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     854|     868|       8
---------------------------------------------------------------------------
  854-  868 (26.85/17.98)	LEQITSFALG.MSYHL
  870-  885 (23.14/14.37)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.67|      30|     149|     925|     959|       9
---------------------------------------------------------------------------
  925-  959 (42.48/43.86)	LCivAVLRHYhaCLILNQDQMAqVFEGLCGVVKHG
 1078- 1107 (56.19/36.54)	LC..AELTGY..CKSLSAEWLG.VLKALCCSSNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.73|      26|     149|    1788|    1813|      11
---------------------------------------------------------------------------
 1788- 1813 (47.52/24.25)	STKGK......KRSQPA..TKNEDYGMGPGRSGP
 1826- 1859 (37.21/17.25)	ANPGSishlsyRQSSMGlyTQNQPLPAGGPRVDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.99|      16|      18|     347|     364|      18
---------------------------------------------------------------------------
  347-  364 (25.84/19.65)	FSDLLM.CPQhrPLVFGLS
  367-  383 (25.15/11.84)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24570 with Med12 domain of Kingdom Metazoa
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