<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24560

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSTQTSQQPTLGPTNSFPTPASSVSGHFMGPTSVEDSEHAGTSFEHVQADSGATTATGLHASSTQQSEHRRTDHDRELEGPTPGIDVRDFAGMDVPHTRDDTDAMDVDKDVNASAKSDGLSLESLQQDFSSAFHLCKSSLIATGPDPALDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKHDPSAPGGLRHLTMWPEEEWQNQKVYGKEIKVADVDSALHNLQMKAMQMEPGTVPNNEYWEDVLGHEKPSKHAGHWDGKKAATLPNTARSPSQANESPLPTEPERARPSRGRKRHYDDNSFVGYGEGYADDDDDAAFYSNSEGMGKKKRKKVRSHAIWDGSWTRLIVLVFLKEHVSKVSTPLPDRGGSYGVGMFGIGAR
Length398
PositionHead
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.06
Grand average of hydropathy-0.782
Instability index36.36
Isoelectric point6.10
Molecular weight43309.46
Publications
PubMed=18404212

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.29|      54|      62|       2|      63|       2
---------------------------------------------------------------------------
    2-   61 (85.51/48.89)	STQTSQQPTLGPTNSF..PTPASSVSgHFMG...PTSVEDSEHAgtsfeHVQADSGATTAT.GLHA
   63-  122 (80.78/38.83)	STQQSEHRRTDHDRELegPTPGIDVR.DFAGmdvPHTRDDTDAM.....DVDKDVNASAKSdGLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.54|      15|      81|     263|     277|       3
---------------------------------------------------------------------------
  263-  277 (31.02/16.88)	LGHEKPSKHAGH..WDG
  343-  359 (24.51/12.01)	MGKKKRKKVRSHaiWDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.26|      11|      15|     316|     326|       4
---------------------------------------------------------------------------
  316-  326 (21.67/15.08)	DDNSFVGYGEG
  332-  342 (20.59/13.97)	DDAAFYSNSEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24560 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNLQMKAMQMEPGTVPNNEYWEDVLGHEKPSKHAGHWDGKKAATLPNTARSPSQANESPLPTEPERARPSRGRKRHYD
2) MSTQTSQQPTLGPTNSFPTPASSVSGHFMGPTSVEDSEHAGTSFEHVQADSGATTATGLHASSTQQSEHRRTDHDRELEGPTPGIDVRDFAGMDVPHTRDDTDAMDVDKDVNASAKSDGLS
239
1
316
121










Molecular Recognition Features






MoRF SequenceStartStop




NANANA