<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24555

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDCASSASFRVGPPSPSSPASGSLKEDHPPYISSENIPQTPTSPPLMSVSAQNYATNITSSQPPSQATSQPANLSSPPSSAPMSTQTSQQPTVGMATSFPTPASSVSGHFMGPTSGEDSEQAEKAFGHARADTGTNSGTDMSAASTQQSEHRRTDHDRDLATSTSDIGIRDFANMDHQIARSDTDAMDIDKDTGASSNPNGLSLESLQQDFSSAFHLCKSSYVATGPDPTLDLISLYGLGPVAKSVARLDPNTGEKINRLRKSYEGKLKGLGLAGRNKPVKHEPNMPGGLRHLTMWPEEEWYNQKVYGKDIKVADMESALQNLQMKAMQMEPGTVPNNDYWEDVLGHEKPSKHVGHSDGKKASVPPNGPRAVSQSNGTPVPTELDRARPSRGRKRHYDDSSFVGYGEGYADDDDDGAFYSNSEGIGKKKRKKDHVSKVSTPLPDRGGSYGVGMFGIGAR
Length460
PositionHead
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.06
Grand average of hydropathy-0.831
Instability index48.23
Isoelectric point5.97
Molecular weight49143.42
Publications
PubMed=18404212

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24555
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.12|      30|      30|      60|      89|       1
---------------------------------------------------------------------------
   14-   42 (28.07/ 8.01)	....PP.S..PSSPASGSlkedHPPYiSSENIPQTP
   60-   87 (46.95/18.20)	TSSQPP.SQATSQPANLS....SPPS.SAPMSTQ..
   88-  116 (42.96/16.05)	TSQQPTvGMATSFPTPAS....SV...SGHFMGPTS
  118-  143 (28.14/ 8.04)	EDSEQA.EKAFGHARADT....GTNS.GTDMS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.37|      25|      30|     237|     266|       2
---------------------------------------------------------------------------
  237-  261 (42.28/26.39)	LYGLGPVAKS.VARLDPNTGEKINRL
  269-  294 (41.10/16.02)	LKGLGLAGRNkPVKHEPNMPGGLRHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.14|      10|      17|     158|     167|       4
---------------------------------------------------------------------------
  158-  167 (16.76/ 9.96)	DRDLATSTSD
  177-  186 (17.38/10.62)	DHQIARSDTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.61|      11|      15|     399|     409|       5
---------------------------------------------------------------------------
  399-  409 (21.38/11.86)	DDSSFVGYGEG
  415-  425 (21.23/11.73)	DDGAFYSNSEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24555 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDGAFYSNSEGIGKKKRKKDHVSKVSTPLPDRGGSYGVGMF
2) SALQNLQMKAMQMEPGTVPNNDYWEDVLGHEKPSKHVGHSDGKKASVPPNGPRAVSQSNGTPVPTELDRARPSRGRKRHYDDSSFVGYG
3) SDCASSASFRVGPPSPSSPASGSLKEDHPPYISSENIPQTPTSPPLMSVSAQNYATNITSSQPPSQATSQPANLSSPPSSAPMSTQTSQQPTVGMATSFPTPASSVSGHFMGPTSGEDSEQAEKAFGHARADTGTNSGTDMSAASTQQSEHRRTDHDRDLATSTSDIGIRDFANMDHQIARSDTDAMDIDKDTGASSNPNGLSLES
414
319
2
455
407
207










Molecular Recognition Features






MoRF SequenceStartStop




1) RKKDHV
431
436