<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24553

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTQTSSSWELPLLKVRTKSSSVCLFHVRRILIDHLVSASGSVTSKELVKNLSAEPGSAASNPVGAQRSQNGLNPARRLDGQGSSAAIYASFISAVTGALSFQLIRCNNAIPLGSRTLFTAVGGDFYDNPRIVNDDPTAVPSLTTLQIQLTSVGKLTVSLQTISQPGIVRLCSPHVSPAEVYNVQPGADLWLSPSGSIARLVTTKLDTPLASSPPGSSNVGGTTSASAVANRKQWKVNVIQWLQNYGLSVGSVEEEPWVEVEVWEPFYSRLAGETFRQTEEGSSVLPLKRIIWPAKYCFTRKKSTGTESFLGIEERCPAFNEPLEFAEKWFATEHIDHGEPDTKPPPGQQSASKDEEISISRSDFPEGIESLSRAAEYPDLQISSLVYPTPPDGTFPMGIHPSLSSDAAIEDSDSRNPAMSKLSKSRPTEKVSSKDRSNHDMLLSFGPSPGLIIGSGLYDTNDDDDLFGEMNQKDFGFKGITDADFSFFDDPGFGHMSGDMMLDAQETPQIAPESDEHLTQSPAPPPLPEPPFIEEASMQRNIAEQDRASSARLEEEGSGLAPGSDSASGDMDVSSPRKADSQTISPPLSPVEVKKTLFSLSSEKSPLSVNHGPMQGHYNPVAFKQDMLNWDQKYGAEGKFSVKAAESNSPMVSSSKTGDIPTIGLPRRSVRARALEPGALRATGGSKSPSSDQEEPIPSDSDFDSTSETTDDDSDGNLSDSDASIATFPNRKRKRASSHSGSSVALSQEKSLAKSELAITTPRTDDSIFLGNFLSSFSDWSMVGYFSATQSQLSPVLVGKDAQIQVAQLLVDQVTQSSLDHKIDGTLGVSNLETKAYSLRTFLEDTAFMGEIERLDLNGFTSLQEASDASPQPAVAMSRQSSQRKESGKGSMSKLAPPHLRVRRGKDYLEILSPAVFFWETFGLEPASGPKDVSVYCIHPHIAAEATNAFLERLGLLYSSCNLGQHSRGSISESFERGMCSWYVGTSGELSYPSIMQSLKSICDRLVMALLKSPPNRDNVVVYIISPFSSAAALADICAAFWGLFQKYISGIEKQQDRQADELVLQIVPFEFTMSTESLVVPLQAQYLNLALEVYSRCPPNTLQPNPINCAPPMLLAEPTPKSINFQLTPEESSPLQGAKSLHLACSRSHDQRWLTVSWSDNTGTLQQTMSYCLRYQNSSAARSILEVRNEIWCVTRSIMEKIQARWRVIIVNTEPVDQDEVDTWTSLVEQHNKVKPALVELAILYANTTPDLYLEPPPLPLPMSIFNPHISSTPVATPNPSGNVFSPEQYGNAPTPPSGANAPTPTEFPADAESESLLIDICDETWGVILSHRLNSSSHLTDYRPALASGYLFRRKGPTDADGAFSMNVNLIYAQRPASSYEAFLKDILSKYRDLAALARARGTRNVQQNTFPWHIATAVRAQELLSYVL
Length1431
PositionKinase
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.349
Instability index56.19
Isoelectric point5.07
Molecular weight155794.68
Publications
PubMed=18404212

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24553
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.33|      14|      17|    1267|    1283|       1
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 1267- 1283 (20.40/18.44)	FNP.HISSTPvaTPnPSG
 1286- 1300 (24.93/11.07)	FSPeQYGNAP..TP.PSG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.18|      15|      17|     164|     178|       2
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  164-  178 (29.99/17.97)	QPGIVRLCSPHVSPA
  184-  198 (29.18/17.26)	QPGADLWLSPSGSIA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      16|      21|     686|     705|       3
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  349-  364 (27.27/ 6.10)	QSASKDEEISI.SRSDF
  687-  703 (25.69/21.11)	KSPSSDQEEPIpSDSDF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.35|      16|      21|     964|     980|       4
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  964-  980 (26.69/18.77)	GQHSRGSISESFeRGMC
  988- 1003 (29.65/16.33)	GELSYPSIMQSL.KSIC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.94|      57|     158|     398|     479|       5
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  378-  439 (93.15/59.68)	PDLQISSLVYPTPPDGTF..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pmgihPSLSSDAAIEDSDSRNPAMSKLSKSRPTEKVSSKDRSNH
  449-  466 (13.63/13.67)	PGLIIGSGLYDTNDDDDL......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1378- 1416 (56.16/17.57)	..................fgemnqkdfgfkgitdadfsffddpgfghmsgdmmldaqetpqiapesdehltqspappplpeppfieeasmqrniaeqdrassarleeegsglapgsdsasgdmdvssprkadsqtispplspvevkktlfslsseksplsvnhgpmqghynpvafkqdmlnwdqkygaegkfsvkaaesnspmvsssktgdiptiglprrsvraralepgalratggskspssdqeepipsdsdfdstsettdddsdgnlsdsdasiatfpnrkrkrasshsgssvalsqekslakselaittprtddsiflgnflssfsdwsmvgyfsatqsqlspvlvgkdaqiqvaqllvdqvtqssldhkidgtlgvsnletkayslrtfledtafmgeierldlngftslqeasdaspqpavamsrqssqrkesgkgsmsklapphlrvrrgkdyleilspavffwetfglepasgpkdvsvycihphiaaeatnaflerlgllysscnlgqhsrgsisesfergmcswyvgtsgelsypsimqslksicdrlvmallksppnrdnvvvyiispfssaaaladicaafwglfqkyisgiekqqdrqadelvlqivpfeftmsteslvvplqaqylnlalevysrcppntlqpnpincappmllaeptpksinfqltpeessplqgakslhlacsrshdqrwltvswsdntgtlqqtmsyclryqnssaarsilevrneiwcvtrsimekiqarwrviivntepvdqdevdtwtslveqhnkvkpalvelailyanttpdlyleppplplpmsifnphisstpvatpnpsgnvfspeqygnaptppsganaptptefpadaesesllidicdetwgvilshrlnssshltdyrpalasgylfrrkgptdadgafsmnvnliyaqrPASSYEAFLKDILSKYRDLAALARARGTRNVQQNTFPWH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.99|      21|     156|      52|      77|       6
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   52-   77 (24.55/30.30)	SAEPGSaaSNpVGAQRSQNGLnpARR
  211-  231 (38.43/22.01)	SSPPGS..SN.VGGTTSASAV..ANR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.97|      25|     156|    1081|    1108|       7
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 1081- 1108 (42.32/27.03)	VPLQAQYLNLALEVYSRCPPntlQPNPI
 1240- 1264 (47.65/23.78)	VELAILYANTTPDLYLEPPP...LPLPM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.28|      29|     156|     732|     762|       8
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  544-  576 (44.27/24.47)	EQDRASSarleEEGSGLAPGSDS..ASGDMDVSSP
  732-  762 (42.01/28.65)	KRKRASS....HSGSSVALSQEKslAKSELAITTP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.43|      16|     183|     331|     346|       9
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  331-  346 (31.45/17.47)	ATEHIDHGEPDTKPPP
  511-  526 (29.99/16.27)	APESDEHLTQSPAPPP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.47|      13|     156|    1029|    1042|      11
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 1030- 1042 (24.41/17.50)	SAAALADICAAFW
 1315- 1327 (25.07/12.31)	SESLLIDICDETW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.81|      11|      21|     234|     245|      13
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  234-  245 (19.01/15.57)	WkVNVIQWLQNY
  257-  267 (23.80/14.49)	W.VEVEVWEPFY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.33|      40|      40|     873|     912|      14
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  873-  912 (67.95/40.48)	PAVAMSRQSSQRKESGKGSMSKL.APPHLRVRRGKDYLEIL
  914-  954 (66.38/39.36)	PAVFFWETFGLEPASGPKDVSVYcIHPHIAAEATNAFLERL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24553 with Med13 domain of Kingdom Fungi
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