<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24540

Description Uncharacterized protein
SequenceMPHEPDLNPPLPLPDSKSGKVDAAMLQVLSSHLQLQKEGFLTAWTNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVVDNAQPLVSTLRVVASGLWLAPGDSEEVASALSQALRNCIERSLIGLYYMRFGDVFSKFHQLQSEELFRRGHPALEFAFVANEEAIFIHVIVSSKHIRMLTTGDLEKVLKHSTEATHGLPVIVSPHGIRGSLTGCSPSDLVKQSYFSSTMVKTSNGIVGFPYHVPQGVGCKLRGQNCHVEVSLGFSRPGTDKASQQNKNNVRNLTKFNAAESPVVGQSDHKGSPNHLLDYEKTFLYPAEAVLVPVLQTSLARSSLRRFWLQNWMGPSLPGSLSFIQCAGNVDNSEDPWTEINGTRTQNSYDSSSNSNSSSISSLSASSSDSDYKTTGPSELEADADSLTCRQSVLSSGDQLQNDGLKLGSKRSRTGVTESLSTATNVPVQDAYMSDVGSVEVNNSAITGVGNEPIGSYWDWDDDDRDTVMDIGALLSEFGDFGDFFVNDVLPFGEPPGTVESQALVFSAPDCGDVNSSPVGVMDVSDQMLLPVGFTSFESSNPPPPVAMEECLSKNQDNLSNSMSSVPVNQTQMSCTREVEHIMKAEAMMIFTAEFGAVETPTSDLSTLFTSPYFPKSRKAESSNSSSNNYLYGAAPPSTPYIDGSEGKNGIVATTKTICGKHDASMSLHPRNYYNYVESRKDINDRKPANLNDNGIGKSQGMVQPLFSKIGSNAVTKSVLRKMSEGTHETEHFLFSAKTLLATDVMCVMLQASMCRLRHILLSSSNLMPVGLSRSTGATFFNQLPGDPSTTTDNISNKYEVKKKENIPVRIAGDIDGGMLDGHHNAPVGVWRTVGVSKVVKSSNSPNMEVGPSFSHTSFNEEGMLSYSQRKPLQELLDGIPLLVQQAISFVDLALDADWGDGPYGLLALQEQWRRGFCCGPSMVHAGCGGTLASSHSLDIAGVELVDPLSADVHASTVISLLQSDVKTALKSAFSNLEGPLSVTDWCKGRNQLVDAGSIVDGVSAESSISECRDSSEPMSPSQSSVGGSSSIKGSSMMDSAKVDEISQRRSGQDMCSSESERQPCSRLKPTLTALPFPSILMGYQDDWLKTSANCLQYWEKAPLEPYALQKPITYHVVCPGIDPLTSAAADFFQQLGTVYETCKLGTHSPQVLGNQMEIESGKLSSSGFVLLDCPQSMKIESSHASLVGSISDYFLSLSNGWDLTSYLKSLSKALRALKLSSCLSTNPIEGSNSSCMVIYVVCPFPDPTAILQTVIESSVAIGSVIQQSDREKRSTLHSQVLKALSGLATVDEASASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELAILKETAFTVYSKARRISRGISSDFSLSAFSGRSHSVLTQMPSPISGMWKDSVGPRIVGHSLPREGDIDTSLRSGGWDNSWQPTRSAGLNCDPSRSGDTFLHDEIRYMFEPLFILAEPGSLDHGTSVIGSPTSESSKALGDDSSGSYMQQSTSTAGSMDSASSIDGLGSDQKTPPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFAQVLQQGCLILQSCDTSLAKPRDFVIARIGGFYELEYIEWQKAIYSFGGSEMKRWPLQLRKYMSDGVSITSNGSSLQQPEMSLIPERTLPSSPSPLYSPHTKATGFMKGGSLGQSAVRKQHMGGHSMVDNNSRGLLHWAQSISFVAVSMDHTLQLVLPASDSSGYTEGFTPVKSLGSTSCAYVVIPSPSMRFLPPTALQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDHRSNLKEEWPAVLSVSLIDYYGVANIRGINNKQQGGGRSLSWEAKDFETETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKKSEKS
Length1934
PositionKinase
OrganismLupinus angustifolius (Narrow-leaved blue lupine)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> genistoids sensu lato> core genistoids> Genisteae> Lupinus.
Aromaticity0.07
Grand average of hydropathy-0.228
Instability index55.90
Isoelectric point5.60
Molecular weight209426.69
Publications
PubMed=27557478

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24540
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.49|      22|      26|    1481|    1502|       1
---------------------------------------------------------------------------
 1481- 1502 (39.31/26.78)	LDHGTSVIGSPTSESS.KALGDD
 1508- 1530 (35.17/22.86)	MQQSTSTAGSMDSASSiDGLGSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.17|      25|      26|    1406|    1430|       2
---------------------------------------------------------------------------
  337-  352 (21.58/ 6.69)	...WlQNWMGP......SLP..GSLSF
 1406- 1430 (47.43/23.81)	SGMW.KDSVGP.RIVGHSLPREGDIDT
 1434- 1459 (45.16/22.31)	SGGW.DNSWQPtRSAGLNCDPSRSGDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     404.53|     106|     127|    1144|    1270|       3
---------------------------------------------------------------------------
  526-  604 (83.28/38.90)	.................................GTVESQALV.FSAPDCGD.VNSSPV..G.VMDVS......DQML.LPVG..FTSFESSnppppvameecLSKNQD..NLSNSMSSVPVNQTQMSC..
  620-  732 (143.43/74.91)	FTAEFGAVeTPTSDLSTlfTSP.YFPKSRKAESSNSSSNNYLYGAAPPSTPyIDGSEGknGIVATTKticgkhDASMSL.HPRNYYNYVES............RKDINDRK.PANLNDNGI..GKSQGMV
 1161- 1267 (177.81/119.03)	FFQQLGTV.YETCKLGT..HSPqVLGNQMEIESGKLSSSGFVLLDCPQSMK.IESSHA..SLVGSIS......DYFLSLSNGWDLTSYLKS...........LSKALRALKLSSCLSTNPIEGSNSSCMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.89|      28|      28|     154|     181|       4
---------------------------------------------------------------------------
  154-  181 (48.19/31.36)	EFAFVANEEAIF.IHVIVSSKHIRMLTTG
  184-  212 (44.70/28.54)	EKVLKHSTEATHgLPVIVSPHGIRGSLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     334.48|      90|     737|     887|     990|       5
---------------------------------------------------------------------------
  887-  981 (147.44/76.11)	SFNeeGmlSYSQRKPLQ...ELLDGIPL......LVQQAISFVDLALDADWGDGPYGLLALQEQWRRGFCCG..P..SMVHAGCGGTLASSHSLdIAGVELVDPLSAD
 1631- 1719 (131.58/56.26)	SFG..G..SEMKRWPLQlrkYMSDGVSItsngssLQQPEMSLIP...ERTLPSSPSPLYSPHTK.ATGFMKG..G..SL...G.QSAVRKQH...MGGHSMVDNNSRG
 1721- 1775 (55.46/18.42)	...........................L......HWAQSISFVAVSMDHTL......QLVLPASDSSGYTEGftPvkSLGSTSCAYVVIPSPSM..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.29|       9|     123|    1144|    1153|       6
---------------------------------------------------------------------------
 1144- 1153 (16.92/13.44)	YhVVCPGIDP
 1269- 1277 (22.37/12.16)	Y.VVCPFPDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.43|      18|      26|      67|      85|       7
---------------------------------------------------------------------------
   67-   85 (30.01/24.61)	LWLfIPGRHSSVVDN.AQPL
   96-  114 (27.42/16.09)	LWL.APGDSEEVASAlSQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.50|      10|      24|     761|     770|       8
---------------------------------------------------------------------------
  761-  770 (17.29/11.58)	HFLFSAKTLL
  788-  797 (17.21/11.48)	HILLSSSNLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.57|      24|      24|    1033|    1056|       9
---------------------------------------------------------------------------
 1033- 1056 (41.10/19.75)	SAESSISECRDSSEPMSPSQSSVG
 1058- 1081 (39.47/18.68)	SSSIKGSSMMDSAKVDEISQRRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.14|      25|     378|     123|     151|      12
---------------------------------------------------------------------------
  123-  151 (39.47/34.73)	IGLYYMRFGDvFSKFHqlqSEELFRRGHP
  500-  524 (46.67/27.86)	IGALLSEFGD.FGDFF...VNDVLPFGEP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24540 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDPWTEINGTRTQNSYDSSSNSNSSSISSLSASSSDSDYKTTGPSELEADADSLT
2) GTSVIGSPTSESSKALGDDSSGSYMQQSTSTA
3) PGTDKASQQNKNNVRNLTKFNAAESPVVGQSDHKGS
363
1484
266
417
1515
301










Molecular Recognition Features






MoRF SequenceStartStop




NANANA