<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24514

Description Uncharacterized protein
SequenceMREIKVQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVFSKVEGFMASQNESGSSTKTTPSLPKNIYKDPDDGRQRLLLELEFIQCLANPTYIHYLAQNRYFEDEGFIEYLKYLQYWQRPEYIKFIMYPHSLYFLELLQNANFRNAMAHPNNKELAHRQQFYFWKNYRNNRLKHLLPRSLPETSATPAPPAPTSTSNQMPLPALPPAPTTNVTVTASSTRAPSPMPYGIPPGSTIPKNEMRNSAVEKRKRK
Length251
PositionMiddle
OrganismLupinus angustifolius (Narrow-leaved blue lupine)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> genistoids sensu lato> core genistoids> Genisteae> Lupinus.
Aromaticity0.10
Grand average of hydropathy-0.659
Instability index50.30
Isoelectric point9.66
Molecular weight28761.54
Publications
PubMed=27557478

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364129
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24514
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.16|      16|      22|     194|     209|       1
---------------------------------------------------------------------------
  194-  209 (32.95/16.92)	STSNQMPLP.ALPPAPT
  218-  234 (28.20/13.50)	STRAPSPMPyGIPPGST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.82|      10|      21|      83|      95|       2
---------------------------------------------------------------------------
   83-   95 (16.15/19.66)	FIQCLanpTYIHY
  107-  116 (19.67/12.11)	FIEYL...KYLQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.88|      17|      17|     136|     152|       3
---------------------------------------------------------------------------
  118-  131 (19.09/ 9.91)	...QRPEYIKFIMYPHS
  136-  152 (28.51/18.23)	ELLQNANFRNAMAHPNN
  154-  170 (31.28/20.67)	ELAHRQQFYFWKNYRNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24514 with Med31 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLPRSLPETSATPAPPAPTSTSNQMPLPALPPAPTTNVTVTASSTRAPSPMPYGIPPGSTIPKNEMRNSAVEKRKRK
175
251










Molecular Recognition Features






MoRF SequenceStartStop




1) FWKNYR
2) IPKNEMRNSAVEKRK
163
235
168
249