<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24486

Description mediator of RNA polymerase II transcription subunit 24 isoform X2
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASLHTSQGLGQGGTRANQPTASWTAIEHCLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHSEQLHKTGFPTVHAVVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTGELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVSSAFEFLLKLTPLLDKADQRCNCDCTNFLLQECSKQGLLSEASTNNLMAKRKADREHAPQLKSDENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHRSEESTKAASVRALLFDISFLMLCHVAQTYGSEVILSESNTGGEVFFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEIKLVQMKWHEACLNISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILEHMCADVLQQTATQIKFPSTGMDAMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRQREDIEDYISLFPLDDMQPSKLMRLLSSNEEDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLDSDLFPNRSHGILLLPAATPPSQPTCSCSFPPSWGLGPPAPTRSSCSGSWRTAWTAWNRAAEAASCSSCPLPRYRNW
Length997
PositionTail
OrganismPhyseter macrocephalus (Sperm whale) (Physeter catodon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Physeteridae> Physeter.
Aromaticity0.07
Grand average of hydropathy-0.096
Instability index48.80
Isoelectric point6.83
Molecular weight111047.29
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24486
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.84|      81|     115|     635|     720|       1
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  635-  720 (126.15/109.08)	LAVCAVAWLVAHV..RMLGLDEREKSLQMIrQLagpLYSENTLQFYNERVVIMSSILEHMCADVlQQTATQIKFPSTGMDAMPYWNLL
  755-  837 (137.68/99.48)	LHMGGVYWFCNNLikELLKETRKEHTLRAV.EL...LYSIFCLDMQQVTLVLLGHILPGLLTDS.SKWHSLMDPPGTALAKLAVWCAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.37|      58|      66|     500|     558|       2
---------------------------------------------------------------------------
  500-  558 (99.12/82.12)	ESTKAASVRALLFDISFLMLC....HVAQTYGSEVILSESNT..GGeVFFFETWMQTCMPEEGKI
  569-  632 (83.25/63.27)	DSTKVESLVALLNNSSEIKLVqmkwHEACLNISAAILEILNAweNG.VLAFESIQKITDNIKGKV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.24|      25|      66|      92|     116|       3
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   92-  116 (45.63/29.93)	LCVQALLDIMDMFCDRLSCH.GKAEE
  120-  140 (35.03/21.15)	LC.RALLSALHWL...LRCT.AASAE
  160-  185 (34.57/20.77)	MCLQRLEKTLSSTKNRALLHiAKLEE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.27|      14|      17|     941|     954|       4
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  941-  954 (32.66/18.73)	PSQPTCSCSFPPSW
  961-  974 (28.60/15.47)	PTRSSCSGSWRTAW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.74|      26|     115|     311|     336|       7
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  270-  287 (21.49/10.69)	......EGTMNL.....TGETQ.PLVEQLM
  311-  336 (45.47/31.61)	GLIESPEGTGELK...WTAFTF.LKIPQVL
  338-  367 (28.78/17.05)	KLKKYSHGDKDFTedvSSAFEFlLKLTPLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24486 with Med24 domain of Kingdom Metazoa
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