Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | HYSHKRDKDAPPNPRSPANSGRRPIPPAAAPLAGGHHPPLLASRREPSPKSGCVGPPIPTPLPPIQHPLARPPSIKEQGAEMAAMGDDLRLDFDKLPIKRLEATDEAGNEHYPPDGSSEAQRLAAIRRVDFSWVVERDAKKAKKAAAEDAAHKAWPWQGLHESLQLAQQELTVVLDLISAVEANDTVAVAATISKPKPLPDEVLVDMAVSAATKLQRLRHLGQYFKQSAKTMEQQFQKEARFYGSLIRLQQNWKVKRQRGNAPGSNSFMFDVVDTSQLDTTAMSRLSSLPLVPIDQDSSGILSVHVPQKSCRFLSVQFLGDSASGAEGYASKAKGISSTTSSAAEDDASENDDVNKSVKQAHSIFRNIHKSIFEEQVFDMVIRETFVQTQGINVTGMREDFLQLAIGQESLLCLSLAISGQDSDSEMVGHEEHTNSEANLVLATTNGKQEPLKSGASGFLSPKSLEIYLLHMFHDNILKKVRDKYRNIVRYQSPAHTAEPAG |
Length | 502 |
Position | Head |
Organism | Aegilops tauschii subsp. strangulata (Goatgrass) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.495 |
Instability index | 51.91 |
Isoelectric point | 6.67 |
Molecular weight | 54940.33 |
Publications | PubMed=25035499 PubMed=29158546 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP24449 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 59.07| 16| 20| 22| 41| 1 --------------------------------------------------------------------------- 22- 38 (28.54/13.74) RRPIPPAAAPLaGGHHP 44- 59 (30.52/15.31) RREPSPKSGCV.GPPIP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.75| 13| 21| 324| 336| 2 --------------------------------------------------------------------------- 324- 336 (22.12/14.94) SGAEGYASKAKGI 342- 354 (21.63/14.44) SAAEDDASENDDV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 54.20| 16| 21| 210| 225| 3 --------------------------------------------------------------------------- 210- 225 (26.83/19.39) SAATKLQRLRHLGQYF 228- 243 (27.37/19.93) SAKTMEQQFQKEARFY --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GRRPIPP 2) HYSHKRDKDAP 3) PLLASR | 21 1 39 | 27 11 44 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab