<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24446

Description Mediator of RNA polymerase II transcription subunit 17
SequenceHYSHKRDKDAPPNPRSPANSGRRPIPPAAAPLAGGHHPPLLASRREPSPKSGCVGPPIPTPLPPIQHPLARPPSIKEQGAEMAAMGDDLRLDFDKLPIKRLEATDEAGNEHYPPDGSSEAQRLAAIRRVDFSWVVERDAKKAKKAAAEDAAHKAWPWQGLHESLQLAQQELTVVLDLISAVEANDTVAVAATISKPKPLPDEVLVDMAVSAATKLQRLRHLGQYFKQSAKTMEQQFQKEARFYGSLIRLQQNWKVKRQRGNAPGSNSFMFDVVDTSQLDTTAMSRLSSLPLVPIDQDSSGILSVHVPQKSCRFLSVQFLGDSASGAEGYASKAKGISSTTSSAAEDDASENDDVNKSVKQAHSIFRNIHKSIFEEQVFDMVIRETFVQTQGINVTGMREDFLQLAIGQESLLCLSLAISGQDSDSEMVGHEEHTNSEANLVLATTNGKQEPLKSGASGFLSPKSLEIYLLHMFHDNILKKVRDKYRNIVRYQSPAHTAEPAGDECGLLGHFCMTVAHKIFSNKVQLELESVVSRVPYLHLQSLPTWHSRTSSWSICLRVPQPILAADRLTKPSDNGEPKYKSSRTQFNTKIVLKDGQISLLGEGSPSIAGSLTRKLSDGYLINSYSCDLEDLPTMVLQQVASQVISWLHEEAQVLGTSVTRDFLGLYFDLDHGDTTLGLVAHVDPDDAYGCVSWYLTVDQPAEEDRKALAADDPWAEEKCRFLGYLSLEVLYSTLMDLINLCGTGAHPLR
Length750
PositionHead
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.06
Grand average of hydropathy-0.373
Instability index45.64
Isoelectric point5.94
Molecular weight82453.23
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24446
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.82|      69|     155|     293|     447|       1
---------------------------------------------------------------------------
  293-  367 (101.72/176.32)	PIDQDSSGILSvhvPqKSCRFLSVQFLGDSAsgAEGYASKAKGISSTTSSA..AEDDASENDDVNK.SVKQAHSIFRN
  451-  522 (114.10/45.27)	PLKSGASGFLS...P.KSLEIYLLHMFHDNI..LKKVRDKYRNIVRYQSPAhtAEPAGDECGLLGHfCMTVAHKIFSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.07|      22|      32|      12|      43|       2
---------------------------------------------------------------------------
   12-   39 (36.28/32.42)	PNPRS.....PANSgrrPIPPAAAPLAgghHPP
   47-   73 (41.79/14.89)	PSPKSgcvgpPIPT...PLPPIQHPLA...RPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.54|      22|      42|     103|     124|       3
---------------------------------------------------------------------------
   99-  120 (36.02/21.40)	KRLEATDEAGNEHYPPDGSSEA
  121-  142 (31.31/17.66)	QRLAAIRRVDFSWVVERDAKKA
  143-  163 (35.21/20.76)	KKAAAED.AAHKAWPWQGLHES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.44|      40|      44|     571|     614|       4
---------------------------------------------------------------------------
  574-  614 (64.03/41.96)	DNGE..PKYKSSRTQFNTkIVLKD..GQ.ISLLGEGSPSIAGSLTR
  617-  661 (57.41/26.94)	SDGYliNSYSCDLEDLPT.MVLQQvaSQvISWLHEEAQVLGTSVTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.20|      16|      20|     210|     225|       5
---------------------------------------------------------------------------
  210-  225 (26.83/14.03)	SAATKLQRLRHLGQYF
  228-  243 (27.37/14.43)	SAKTMEQQFQKEARFY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24446 with Med17 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HYSHKRDKDAPPNPRSPANSGRRPIPPAAAPLAGGHHPPLLASRREPSPKSGCVGPPIPTPLPPIQHPLARPPSIKEQGAEMAAMGDDL
1
89










Molecular Recognition Features






MoRF SequenceStartStop




1) APLAGGHH
2) HYSHKRDKDAP
3) PLLASRR
4) SGRRPIPP
30
1
39
20
37
11
45
27