<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24398

Description Mediator of RNA polymerase II transcription subunit 17
SequenceQLPRSKPLPYLPCLRSARRPIPPAAAHRRQPPTHPPLFAPAPASRRQHPGQSISPLAPSPSIKEQGQQMAAMGDDLRLDLDKLPIKRLEAIDEAGNEHYPPDTSSEEQRLAAIRRVDFSWVVERDAKKAKKAAAEDAAQKAWPWQGLHESLQLAQQELTVVLDLISTVEANDTVAVATISKPRPLPDEVLVDMAVSAATKLQRLRHLGRYFKQSAKTMQQQFQKEARFYGSLIRLQQNWKVKRQRGNAPGINSFMFDVVDTSQLDTAAMPRMSSLSLVQIDQDSSGTLSVQVPQKACRFLSLQFRRDSANGPESYACRTKGVSSTTSSAAEDDALEEDDVNKSVKQAHSILRNIHKSIFEEQVLDMVIRETFVQTQGVNVTGMREDFLQLAIGEESLLCLSLVDSGQDSDSEMAGHEHNNSEANLVLATTNGKQEPLKRDTSGFLNPKSLEIYLLHLFHENILRKVREKYRNIVRYQSPAQTAESAGEDSGLLSHFCMTVAHKTYSKKVQLELESVVSRVPYLQLRSLPTWHSRTSSWSLCLRVPQPILAADRPTKPSDNGEPKYKSSRTRFNTKIVLKDGQISLLGEGSPSIAGSLTRKPSDGYLINSYNCDLEDLPTMVLQQVASQIINWLHEEALVLGMSVTRDFLCLYFDLEHGDTLGLVAHVDPDDEYGCISWYLTVDHPAEDDGKAPAADDPWAEKRRFLGYLSLEVLYSTLLDLINLCGTGARPLR
Length733
PositionHead
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.06
Grand average of hydropathy-0.444
Instability index54.51
Isoelectric point6.30
Molecular weight81770.70
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.41|      14|      16|      28|      42|       1
---------------------------------------------------------------------------
   28-   42 (27.20/21.21)	RRQPPTH..PPLfAPAP
   45-   60 (25.21/13.68)	RRQHPGQsiSPL.APSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     372.79|     121|     249|     263|     412|       2
---------------------------------------------------------------------------
  284-  412 (181.61/178.36)	SSGTLSVQVPQKAcrFLSLQFRRDSANGPESY.ACRTKGVSSTTSSAAEDDALEEDD..VNKSV..KQAHSILRNIHKSIFEE...........QVLDMVIRETFVqtQGVNVTgmrEDFLQLAIGEESLLCLSLVdSGQDSDSE
  536-  672 (191.18/122.28)	SSWSLCLRVPQPI..LAADRPTKPSDNGEPKYkSSRTRFNTKIVLKDGQISLLGEGSpsIAGSLtrKPSDGYLINSYNCDLEDlptmvlqqvasQIINWLHEEALV..LGMSVT...RDFLCLYFDLEHGDTLGLV.AHVDPDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.69|      16|      16|     196|     211|       3
---------------------------------------------------------------------------
  196-  211 (27.42/19.23)	SAATKLQRLRHLGRYF
  214-  229 (28.27/20.06)	SAKTMQQQFQKEARFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.61|      42|     554|     119|     165|       4
---------------------------------------------------------------------------
  119-  165 (66.56/51.55)	SW..VVERDAKKAKKAAAEDAaqkawPWQGLHESLQ.LAQQEL.TVVLDLI
  677-  722 (62.06/36.90)	SWylTVDHPAEDDGKAPAADD.....PWAEKRRFLGyLSLEVLySTLLDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24398 with Med17 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RSKPLPYLPCLRSARRPIPPAAAHRRQPPTHPPLFAPAPASRRQHPGQSISPLAPSPSIKEQGQQMAAMGDDL
4
76










Molecular Recognition Features






MoRF SequenceStartStop




1) LPRSKPLPYLPCLRSARRPIPPAAAHRRQ
2
30