<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24389
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAAMGDDLRLDLDKLPIKRLEAIDEAGNEHYPPDTSSEEQRLAAIRRVDFSWVVERDAKKAKKAAAEDAAQKAWPWQGLHESLQLAQQELTVVLDLISTVEANDTVAVATISKPRPLPDEVLVDMAVSAATKLQRLRHLGRYFKQSAKTMQQQFQKEARFYGSLIRLQQNWKVKRQRGNAPGINSFMFDVVDTSQLDTAAMPRMSSLSLVQIDQDSSGTLSVQVPQKACRFLSLQFRRDSANGPESYACRTKGVSSTTSSAAEDDALEEDDVNKSVKQAHSILRNIHKSIFEEQVLDMVIRETFVQTQGVNVTGMREDFLQLAIGEESLLCLSLVDSGQDSDSEMAGHEHNNSEANLVLATTNGKQEPLKRDTSGFLNPKSLEIYLLHLFHENILRKVREKYRNIVRYQSPAQTAESAGEDSGLLSHFCMTVAHKTYSKKVQLELESVVSRVPYLQLRSLPTWHSRTSSWSLCLRVPQPILAADRPTKPSDNGEPKYKSSRTRFNTKIVLKDGQISLLGEGSPSIAGSLTRKPSDGYLINSYNCDLEDLPTMVLQQVASQIINWLHEEALVLGMSVTRDFLCLYFDLEHGDTLGLVAHVDPDDEYGCISWYLTVDHPAEDDGKAPAADDPWAEKRRFLGYLSLEVLYSTLLDLINLCGTGARPLR |
Length | 665 |
Position | Head |
Organism | Aegilops tauschii subsp. strangulata (Goatgrass) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade>
Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.398 |
Instability index | 47.24 |
Isoelectric point | 5.57 |
Molecular weight | 74351.20 |
Publications | PubMed=25035499
PubMed=29158546
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP24389
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.44| 10| 123| 207| 216| 1
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207- 216 (18.16/ 9.97) LSLVQIDQDS
332- 341 (18.28/10.08) LSLVDSGQDS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 303.31| 84| 355| 175| 271| 2
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175- 271 (129.36/72.37) RQRGNAPGINSFMFDVVDtsqLDTAAMPRMSSlslvqidqdsSGTLSVQVPQK.ACRFLSLQFRRDSAN.....GPES.Y.ACRTKGVSSTTSSAAEDD..ALEEDD
469- 522 (62.62/28.38) ..........................................SWSLCLRVPQP.I..LAADRPTKPSDN.....GEPK.YkSSRTRFNTKIVLKDGQIS..LLGEGS
531- 629 (111.34/56.44) RKPSDGYLINSYNCDLED...LPTMVLQQVAS.qiinwlheeALVLGMSVTRDfLCLYFDLE.HGDTLGlvahvDPDDeY.GCISWYL..TVDHPAEDDgkAPAADD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 105.13| 33| 319| 105| 142| 5
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105- 142 (47.12/43.44) TVAVATISKPRPLPdevlVDMAVSAATKLQrLRHLGRY
431- 463 (58.00/37.54) TVAHKTYSKKVQLE....LESVVSRVPYLQ.LRSLPTW
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