<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24261

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTGKTSESENNQIKKELDSVNDPHLGADGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDCMGSSPCEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVVSKRSRSEITEVSSHAGKEVRENMQGTNGQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPAALFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESARDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTMQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSAMQTESSSNSDLVPKYDMKRKESIPARLSSDADHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESVAMGDAYSFHYTGDIRESSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSASCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKEIKLNLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRSQSAMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGSENDSAMSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNMRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHPKSSFTKGQPGNKKQILAEQTGIEGSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSSTGASSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKQPTKEDSRHSVLSVSIVDYYGGTVQDKMSRGSKQAARHETSARDYVTDMHNVLEAVAAELHALSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1889
PositionKinase
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.08
Grand average of hydropathy-0.304
Instability index59.61
Isoelectric point5.83
Molecular weight206131.74
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     400.20|     117|     122|    1246|    1363|       1
---------------------------------------------------------------------------
 1181- 1248 (67.21/34.13)	LSKSWSVKSFLssLARIIKEikLNLNISTNQK.ESSNipctvVYVVCPFP.EPSAVLQ...TL.VES.........................................................................svalGSI
 1249- 1374 (187.07/113.52)	LSSERERKSFL..YAQVAKA..LNSSASADEA.SASN.....VVMLSGFS.IPKLVLQ...IVTVETLLRLHKPNELaAFKDIA....FTVYNKARRIPRFVS.TSDMFQSPTYM.SRSQSAM.MHTASPGPTLWKeclaprmsGQT
 1375- 1491 (145.91/83.81)	LSRETE...F........DA..SMRSVSWDNSwQPGR.....AVGLPDPSkIPELCAQddrKYAFEPLFILAEPGAV.DYNDTMessrFGVDASSSRVYSSISgGTDSGASPLLEgSENDSAMsLHCCYGWTEDWR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.79|      16|     122|     140|     158|       2
---------------------------------------------------------------------------
  140-  158 (23.26/21.76)	LRGLSYarFGDVFTKYnPP
  263-  278 (31.54/17.00)	LRGQSY..YVEVALGF.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.30|      22|      54|     337|     358|       3
---------------------------------------------------------------------------
  337-  358 (39.46/19.25)	VHQ.AFVRFSSKRMWSQDCMGSS
  360-  382 (33.85/15.50)	CEAwPFWNFSPSSYFRNSSFFGS
  388-  409 (33.99/15.59)	VNS.NFLRLRRQRNSNSNGMASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.68|      19|      54|     669|     687|       4
---------------------------------------------------------------------------
  669-  687 (32.06/19.68)	QSSKVESARDKSEK...SDKLT
  721-  742 (26.63/14.85)	QSCKGETSRPVSGEtsfSSSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.20|      52|      54|     500|     552|       5
---------------------------------------------------------------------------
  500-  552 (88.84/67.94)	MDI.DILLSEFGdFSDF..FQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPS
  555-  609 (77.35/53.23)	MDIpEQRLSPVG.FTSMeaFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.00|      24|      53|     857|     881|       6
---------------------------------------------------------------------------
  857-  881 (35.43/20.73)	LDSLSAKTFSgTSPSVQRQPIVELL
  913-  936 (45.56/23.04)	LDEQRRRGFS.CDPSMVHAGCGGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.26|      25|     627|     197|     225|       8
---------------------------------------------------------------------------
  201-  225 (44.48/30.57)	DIEKVLTHTPRSVG...EGLPVIVAPSG
 1124- 1151 (43.77/20.67)	EVCKLGTHSPQHSGgqiEQSPGKYQPSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.29|      15|      27|      58|      72|      12
---------------------------------------------------------------------------
   58-   72 (31.16/16.65)	FLSTWTNSFVGPWDP
   88-  102 (28.13/14.28)	FLSGRHSSVPEMTQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24261 with Med13 domain of Kingdom Viridiplantae
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