<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24259

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKEIKLNLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRSQSAMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGSENDSAMSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNMRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHPKSSFTKGQPGNKKQILAEQTGIEGSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSSTGASSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKQPTKEDSRH
Length682
PositionKinase
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.217
Instability index64.01
Isoelectric point6.48
Molecular weight74108.12
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24259
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.93|      12|      15|     552|     563|       1
---------------------------------------------------------------------------
  552-  563 (19.65/11.01)	SLHLVRSISLVA
  569-  580 (21.28/12.43)	SLHLACQADLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.67|      48|     193|     109|     177|       2
---------------------------------------------------------------------------
  124-  177 (66.55/73.11)	EPSAV.LQTLVESSvALGSILSSERerksfLYAQVAKALNSSASA.DEASASNVVM
  323-  372 (74.12/36.10)	EPGAVdYNDTMESS.RFGVDASSSR.....VYSSISGGTDSGASPlLEGSENDSAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.28|      32|     193|     284|     317|       3
---------------------------------------------------------------------------
  284-  317 (59.79/43.70)	WdnSWQPGRAV..GLPDPSKIPELCAQD.....DRKYAFEP
  478-  516 (51.50/30.95)	W..PVQLRRSIpdGIPSNSNGPTLEQQDmgliqDRNMPSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.34|      11|      15|     590|     600|       5
---------------------------------------------------------------------------
  590-  600 (18.53/10.34)	QSSSTGASSYL
  607-  617 (18.81/10.63)	KSIGSMSASYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24259 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPDGIPSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHPKSSFTKGQPGNKKQILAEQT
486
544










Molecular Recognition Features






MoRF SequenceStartStop




NANANA