<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24231

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMMQSHMPSPARLGVTASSPSLPPNQSPANPTSSPPQQANPPPASAATSAAGAAVPTLTTSPALLPLLPPLPRAQSLLHLISSLASNLFELSPNRAAWISSYRGSLPNFLASSSASAAPTPLPAPVSTTKEAMSMLTSLQTQLFETVAELQETLDLQDARAKLAREARAKDASLLAFAKKLREAHHVLDRLVDDYADYRRDPKRPRGAAAVDEPEPVSHGDFGASLHSKLKLDDILTYAHRISYTTFAPPEHGAGLPLRGALPPAPQDNELRMSQLYQFADLDVGVPKKPLETKEGVTAEMESMPLFELPEEEPPRPFMLPITVPPGWQKGLPALLPDIPVPPPGWKPGDPIELGGIIPAVKPEEQRPSVPIPVGVQPMVPRAQEPIQVAAVNLDIISSSSDEYSSDVGSSDEDDED
Length416
PositionMiddle
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.05
Grand average of hydropathy-0.310
Instability index63.45
Isoelectric point4.92
Molecular weight44380.80
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24231
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.68|      15|      16|     316|     330|       1
---------------------------------------------------------------------------
  316-  330 (34.29/16.57)	PFMLP.ITV.PPGWQKG
  332-  348 (25.40/10.50)	PALLPdIPVpPPGWKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.74|      48|      51|       8|      55|       2
---------------------------------------------------------------------------
    8-   55 (86.75/27.21)	SPARLG.VTASSPSLPPNQSPANPTSSPPQQANPPPASAATSAAGAAVP
   60-   86 (45.75/11.32)	SPALLP.LL...PPLPRAQSLLHLISS..................LASN
   91-  131 (58.24/16.16)	SPNRAAwISSYRGSLP......NFLASSSASAAPTPLPAPVSTTKEA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.94|      37|      52|     171|     207|       3
---------------------------------------------------------------------------
  171-  204 (53.23/35.96)	..................ASL...LAFAKKLREAHHVLDRLVDDYADYRRD...PKRP
  205-  256 (44.15/28.48)	RGAaavdepepvshgdfgASLhskLKLDDILTYAHRI...SYTTFAPPEHG...AGLP
  258-  289 (38.56/23.88)	RGA............lppAPQ......DNELR.....MSQLY.QFADL..DvgvPKKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.64|      14|      17|     350|     365|       4
---------------------------------------------------------------------------
  350-  365 (17.49/17.57)	PIELgGIIPAVkPEEQ
  370-  383 (28.15/15.98)	PIPV.GVQPMV.PRAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24231 with Med4 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MMQSHMPSPARLGVTASSPSLPPNQSPANPTSSPPQQANPPPASAATSAAGA
2) PALLPDIPVPPPGWKPGDPIELGGIIPAVKPEEQRPSVPIPVGVQPMVPRAQE
1
332
52
384










Molecular Recognition Features






MoRF SequenceStartStop




NANANA