<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24181

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRELVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVNPRPKEVSSISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHEFSISLAMDTIIRQANVLRHGRWKEAISSERISDSTAGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDIGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPSALLDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGVSTRTISQMQDGALSHAQANNTSIVRPGVGVNSYFPTSLSHLQSTNAFSSSNPVRNSSAIKLSNSKPNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITVGSDCAPRKRSLSDFLLDLPSLQGLKSGEPSKRRRISESAQSSLPLQTYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREILKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWLQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1742
PositionTail
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index51.15
Isoelectric point8.26
Molecular weight190216.57
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24181
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      22|      22|     939|     960|       2
---------------------------------------------------------------------------
  939-  960 (42.14/25.93)	QDDSWKHICLRLGKAGSMSWDV
  963-  984 (42.82/26.48)	NDPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      22|    1424|    1433|       3
---------------------------------------------------------------------------
 1424- 1433 (16.81/10.18)	LKKVLRGILK
 1448- 1457 (16.69/10.05)	LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.88|      27|      29|     760|     786|       4
---------------------------------------------------------------------------
  761-  791 (46.25/23.92)	NHDLSSLS.......SPS..EHG....IADGNKPFQLAPsstlP
  792-  816 (27.06/10.93)	AHLVR..S.......SPA..IEGlgkaITVGS...DCAP.....
 1357- 1394 (26.57/10.59)	NHVAASLSragnamlSSSglASG....I..GGASVRLTPgtglP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.78|      25|      28|     693|     720|       5
---------------------------------------------------------------------------
  682-  715 (31.96/20.27)	SPVRSlslgpqGVStrtISQMQDGALSHAQANNT
  716-  740 (44.82/21.78)	SIVRP......GVG...VNSYFPTSLSHLQSTNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.15|      25|     607|     650|     674|       6
---------------------------------------------------------------------------
  650-  674 (48.94/28.82)	DPLPLLPACSPSFSSIVDETFEC........EH
 1270- 1302 (42.21/23.73)	DQVWLQPATPPKGGPSVGGSLPCpqfrpfimEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      28|    1056|    1067|       7
---------------------------------------------------------------------------
 1056- 1067 (22.16/12.00)	VGMKSQSVNKGH
 1086- 1097 (25.19/14.64)	VGLMSFWFSYGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.05|      19|     914|     303|     335|       9
---------------------------------------------------------------------------
  307-  327 (31.17/38.37)	NAAVMQLGQDGEFdsSGFRLP
 1402- 1420 (38.88/11.27)	NTAFIGLGDDGGY..GGGWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.18|      41|     914|     577|     624|      10
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  577-  624 (54.57/59.88)	FHLLETQSDASNkfNANIDAKEAmRVNKIdvgqMEKIKYEKNSNPFDA
 1501- 1541 (72.61/51.29)	FHHQQQQQQAQS..NAQEELTSA.EINEI....CDYFSRRVASEPYDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.60|      15|      22|     349|     370|      11
---------------------------------------------------------------------------
  349-  363 (27.37/25.40)	PFIKIEAGQDMQIKC
  372-  386 (25.23/ 7.71)	PLTDKEANLSLDLSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.18|      28|     239|      25|      52|      12
---------------------------------------------------------------------------
   25-   52 (47.36/28.44)	LALRELVEKSQA..ESDWKGAYGGRQRSDS
  271-  300 (42.81/25.01)	LAMDTIIRQANVlrHGRWKEAISSERISDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      12|      22|     828|     840|      14
---------------------------------------------------------------------------
  828-  840 (17.79/11.11)	LPsLQGLKSGEPS
  853-  864 (21.64/ 9.45)	LP.LQTYSSSSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.46|      17|     404|    1232|    1250|      15
---------------------------------------------------------------------------
 1232- 1250 (26.95/20.83)	LVP.......SSLLPFDVSVVLRgpY
 1632- 1655 (28.52/14.64)	LIPhmnvaggAAWLPYCVSVRLR..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.88|      21|     911|     232|     252|      16
---------------------------------------------------------------------------
  232-  252 (36.56/23.93)	IKLGEIRRFALGDDIER.RMAV
 1146- 1167 (33.33/21.09)	IRLTAGPLLALGGAIRPaRMPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.42|      33|     128|    1169|    1204|      19
---------------------------------------------------------------------------
 1169- 1204 (53.44/40.32)	VSTGYSSMPKQTNNVPSQGPLANGSSATTMhhaSAP
 1303- 1335 (58.98/35.75)	VAQGLNALEPAFMNATQPGPHLNTSAGAPQ...SAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      22|     884|     894|      20
---------------------------------------------------------------------------
  884-  894 (18.00/ 9.46)	ATVYASVLLHV
  909-  919 (20.22/11.47)	AQMYSSAIPYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24181 with Med14 domain of Kingdom Viridiplantae
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