<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24178

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRELVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVNPRPKEVSSISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHEFSISLAMDTIIRQANVLRHGRWKEAISSERISDSTAGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDIGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPSALLDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGVSTRTISQMQDGALSHAQANNTSIVRPGVGVNSYFPTSLSHLQSTNAFSSSNPVRNSSAIKLSNSKPNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITVGSDCAPRKRSLSDFLLDLPSLQGLKSGEPSKRRRISESAQSSLPLQTYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVG
Length1478
PositionTail
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.192
Instability index50.74
Isoelectric point8.27
Molecular weight160975.79
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24178
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.03|      23|      23|     940|     962|       1
---------------------------------------------------------------------------
  940-  962 (44.58/25.27)	DDSWKHICLRLGKAGSMSW..DVRI
  964-  988 (40.45/22.25)	DPHFKELWELNGGSTSTPWgvGVRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.11|      20|      29|     754|     775|       2
---------------------------------------------------------------------------
  754-  775 (31.55/23.48)	KL..SNSKPNHDLSslSSPSEHGI
  783-  804 (29.57/15.61)	QLapSSTLPAHLVR..SSPAIEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      22|    1424|    1433|       3
---------------------------------------------------------------------------
 1424- 1433 (16.81/10.96)	LKKVLRGILK
 1448- 1457 (16.69/10.82)	LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.63|      19|      32|     602|     633|       4
---------------------------------------------------------------------------
  330-  351 (26.68/ 6.69)	KLNYwldGKNSGP..AESDLSPFI
  612-  632 (26.94/35.16)	KIKY...EKNSNPfdAKLHSLQSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.73|      24|      32|     682|     708|       6
---------------------------------------------------------------------------
  659-  679 (34.27/17.82)	SP..SFS....SIV.....DETFECEHG.SSLP
  682-  708 (32.80/27.69)	SPVRSLSlgPqGVS.....TRTISQMQD.GALS
  716-  742 (24.66/10.68)	SIVR.....P.GVGvnsyfPTSLSHLQStNAFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.52|      12|      33|    1375|    1389|       8
---------------------------------------------------------------------------
 1375- 1389 (17.88/15.08)	GLA..SGIGGASVrltP
 1407- 1420 (22.64/10.57)	GLGddGGYGGGWV...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.39|      74|     132|    1151|    1236|       9
---------------------------------------------------------------------------
 1151- 1236 (115.87/75.85)	GPllALGGAI.....RPARMPvTVSTGYSSMPKQTNN.............VPSQGPLANGSSATTMHHASAPSNATAHlgghtlHTAAMLSaagRGGPGLVPSS
 1283- 1374 (116.51/54.21)	GP..SVGGSLpcpqfRPFIME.HVAQGLNALEPAFMNatqpgphlntsagAPQSAPVANRLNATPGVAMSRPTSSVAN......HVAASLS...RAGNAMLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      12|      22|     828|     840|      10
---------------------------------------------------------------------------
  828-  840 (17.79/13.26)	LPsLQGLKSGEPS
  853-  864 (21.64/11.32)	LP.LQTYSSSSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      29|    1056|    1067|      13
---------------------------------------------------------------------------
 1056- 1067 (22.16/12.36)	VGMKSQSVNKGH
 1086- 1097 (25.19/15.08)	VGLMSFWFSYGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.18|      28|     255|      25|      52|      14
---------------------------------------------------------------------------
   25-   52 (47.36/31.22)	LALRELVEKSQA..ESDWKGAYGGRQRSDS
  271-  300 (42.81/27.49)	LAMDTIIRQANVlrHGRWKEAISSERISDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      23|     884|     894|      15
---------------------------------------------------------------------------
  884-  894 (18.00/10.75)	ATVYASVLLHV
  909-  919 (20.22/13.00)	AQMYSSAIPYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24178 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASPVRSLSLGPQGVSTRTISQMQDGALSHAQANNT
2) PVRNSSAIKLSNSKPNHDLSSLSSPSEHGIADGNKPFQ
3) TGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATA
681
746
1171
715
783
1209










Molecular Recognition Features






MoRF SequenceStartStop




NANANA