<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24176

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESSRSRCEAVQCGGRIDDELTLTATRGMEATKVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVNPRPKEVSSISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHEFSISLAMDTIIRQANVLRHGRWKEAISSERISDSTAGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDIGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPSALLDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGVSTRTISQMQDGALSHAQANNTSIVRPGVGVNSYFPTSLSHLQSTNAFSSSNPVRNSSAIKLSNSKPNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITVGSDCAPRKRSLSDFLLDLPSLQGLKSGEPSKRRRISESAQSSLPLQTYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREILKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWLQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1694
PositionTail
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.06
Grand average of hydropathy-0.183
Instability index51.16
Isoelectric point7.75
Molecular weight184514.01
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24176
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      22|      22|     891|     912|       2
---------------------------------------------------------------------------
  891-  912 (42.14/28.86)	QDDSWKHICLRLGKAGSMSWDV
  915-  936 (42.82/29.47)	NDPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      22|    1376|    1385|       3
---------------------------------------------------------------------------
 1376- 1385 (16.81/11.66)	LKKVLRGILK
 1400- 1409 (16.69/11.51)	LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.88|      27|      29|     712|     738|       4
---------------------------------------------------------------------------
  713-  743 (46.25/25.98)	NHDLSSLS.......SPS..EHG....IADGNKPFQLAPsstlP
  744-  768 (27.06/11.97)	AHLVR..S.......SPA..IEGlgkaITVGS...DCAP.....
 1309- 1346 (26.57/11.62)	NHVAASLSragnamlSSSglASG....I..GGASVRLTPgtglP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.78|      25|      28|     645|     672|       5
---------------------------------------------------------------------------
  634-  667 (31.96/26.86)	SPVRSlslgpqGVStrtISQMQDGALSHAQANNT
  668-  692 (44.82/28.86)	SIVRP......GVG...VNSYFPTSLSHLQSTNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.15|      25|     607|     602|     626|       6
---------------------------------------------------------------------------
  602-  626 (48.94/23.51)	DPLPLLPACSPSFSSIVDETFEC........EH
 1222- 1254 (42.21/19.35)	DQVWLQPATPPKGGPSVGGSLPCpqfrpfimEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      28|    1008|    1019|       7
---------------------------------------------------------------------------
 1008- 1019 (22.16/10.89)	VGMKSQSVNKGH
 1038- 1049 (25.19/13.30)	VGLMSFWFSYGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.05|      19|     914|     255|     287|       9
---------------------------------------------------------------------------
  259-  279 (31.17/37.93)	NAAVMQLGQDGEFdsSGFRLP
 1354- 1372 (38.88/11.07)	NTAFIGLGDDGGY..GGGWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.18|      41|     914|     529|     576|      10
---------------------------------------------------------------------------
  529-  576 (54.57/72.81)	FHLLETQSDASNkfNANIDAKEAmRVNKIdvgqMEKIKYEKNSNPFDA
 1453- 1493 (72.61/62.45)	FHHQQQQQQAQS..NAQEELTSA.EINEI....CDYFSRRVASEPYDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.60|      15|      22|     301|     322|      11
---------------------------------------------------------------------------
  301-  315 (27.37/31.26)	PFIKIEAGQDMQIKC
  324-  338 (25.23/ 9.55)	PLTDKEANLSLDLSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      12|      22|     780|     792|      12
---------------------------------------------------------------------------
  780-  792 (17.79/13.86)	LPsLQGLKSGEPS
  805-  816 (21.64/11.82)	LP.LQTYSSSSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.46|      17|     404|    1184|    1202|      13
---------------------------------------------------------------------------
 1184- 1202 (26.95/22.71)	LVP.......SSLLPFDVSVVLRgpY
 1584- 1607 (28.52/15.92)	LIPhmnvaggAAWLPYCVSVRLR..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.88|      21|     911|     184|     204|      14
---------------------------------------------------------------------------
  184-  204 (36.56/27.70)	IKLGEIRRFALGDDIER.RMAV
 1098- 1119 (33.33/24.43)	IRLTAGPLLALGGAIRPaRMPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.42|      33|     128|    1121|    1156|      17
---------------------------------------------------------------------------
 1121- 1156 (53.44/34.11)	VSTGYSSMPKQTNNVPSQGPLANGSSATTMhhaSAP
 1255- 1287 (58.98/30.23)	VAQGLNALEPAFMNATQPGPHLNTSAGAPQ...SAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      22|     836|     846|      18
---------------------------------------------------------------------------
  836-  846 (18.00/10.92)	ATVYASVLLHV
  861-  871 (20.22/13.22)	AQMYSSAIPYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24176 with Med14 domain of Kingdom Viridiplantae
Unable to open file!