<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24073

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNNNSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEDSSHAGKEVRENMQGTNGQGGCSWGWGEEGVVMDINILLSEFGDFSDFFQGDELDFGEPPGTAESHALVSPASEYGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKESIPARLSSDVDHDMYDRSQLENVGVWRSVVVPKGAKPLDSLSAKTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRDTSNSIPIGGDAMSPPQSSNDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHLPQHSGGQIEHSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTVNISTNQKESSNIPCTVIYVVCPFPEPSAVLQALVESSVALGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSMSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDMMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSATSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLMATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPMCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIIDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYPERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGDLA
Length1558
PositionKinase
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.310
Instability index62.09
Isoelectric point5.71
Molecular weight169455.65
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24073
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.32|      37|      55|    1032|    1068|       2
---------------------------------------------------------------------------
 1032- 1057 (36.90/15.74)	..........................LSRETEFDAS..MRSVSWDNSWQPGRAV
 1058- 1111 (46.49/21.79)	GLPDPSKIPELcaqddrkyafeplfiLAEPGTADYSdmMESSRFGADASSSRAY
 1116- 1148 (41.94/18.92)	GGTDSGASPPL...........egseNDSATSLHC.....CYGWTEDWR.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.65|      22|      24|     407|     429|       3
---------------------------------------------------------------------------
  407-  429 (32.93/32.75)	YFLLSMKTALATEIECiTFQAAM
  434-  455 (33.72/27.11)	HTLVSLRTKASAELKS.ALSSAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.51|      30|      31|     189|     218|       4
---------------------------------------------------------------------------
  159-  186 (33.69/20.54)	....SEFGDFsDFFQGDELDFGEPPGTA.ESHA
  189-  218 (53.05/37.61)	S.PASEYGDM.PFIDSPSVAMDIPEQRL.SPVG
  221-  252 (32.77/19.73)	SmEAFNHQTMsPIQDVASKVQE.PLKEIaSPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.31|      41|      54|    1404|    1449|       5
---------------------------------------------------------------------------
 1404- 1449 (63.23/47.41)	SPPLAHLLHSKGTAtplamGYVVSKAVPPV.RKNAAQLTKEDRHSVL
 1460- 1501 (67.08/39.27)	STPTVQEKMSRGVG.....GSTMSKQARNItHETSARDYEMDMHNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.69|      24|     345|     456|     483|       6
---------------------------------------------------------------------------
  456-  480 (36.81/32.34)	QTESS.SNSG.....LVPKyEMKRKESIPAR
  490-  519 (30.88/13.23)	YDRSQlENVGvwrsvVVPK.GAKPLDSLSAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.69|      31|     603|     680|     730|       7
---------------------------------------------------------------------------
  680-  717 (49.93/57.31)	PIGGDAMSPPQSSNDRGTseehhkgYHRVRPTIAVLPS
  737-  767 (56.76/24.40)	KLWEKAPLEPYASAKPVT.......YYALCPDIDMLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.84|      32|      34|     317|     348|      11
---------------------------------------------------------------------------
  317-  348 (51.82/27.57)	YDVTQSSKVESAGDKSEKSDKLTPANLSRDV.G
  353-  385 (50.02/26.38)	YTLVQGRKNESEKSLNNADEQSCKGETSRPVsG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24073 with Med13 domain of Kingdom Viridiplantae
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