<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24068

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHSPRSVGEGLPVIVAPSGMLGRLVGCCPSDLAIQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKEEFDSVKEPHVGDYGQKKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNNNSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEDSSHAGKEVRENMQGTNGQGGCSWGWGEEGVVMDINILLSEFGDFSDFFQGDELDFGEPPGTAESHALVSPASEYGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKESIPARLSSDVDHDMYDRSQLENVGVWRSVVVPKGAKPLDSLSAKTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRDTSNSIPIGGDAMSPPQSTGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHLPQHSGGQIEHSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTVNISTNQKESSNIPCTVIYVVCPFPEPSAVLQALVESSVALGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSMSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDMMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSATSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLMATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPMCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIIDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYPERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGDLA
Length1805
PositionKinase
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.281
Instability index60.55
Isoelectric point5.85
Molecular weight196530.34
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24068
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.37|      61|      98|    1233|    1299|       1
---------------------------------------------------------------------------
 1233- 1299 (104.03/62.52)	PRFVSMSDMFQSPTYMSRPQSTMMHTASPGPTlwKECLVPRMSGQtlsrETEFDASMR.SVSWDNSWQ
 1334- 1395 (105.33/50.81)	PGTADYSDMMESSRFGADASSSRAYSSISGGT..DSGASPPLEGS....ENDSATSLHcCYGWTEDWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.50|      66|     121|      42|     115|       2
---------------------------------------------------------------------------
   42-  115 (94.72/98.67)	LRGLSYarFGDVFTKYNPPTRNQNSfRRAQPTVEFVFAATEEAifvHViiSARYMRNLSSDD....IEKVLTHSPRSV
  165-  234 (107.78/81.34)	LRGQSY..YVEVALGFPPASTDKIS.ESENNQIKEEFDSVKEP...HV..GDYGQKKLESADglpvLERTFIYPPEAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.98|      14|      20|     910|     927|       3
---------------------------------------------------------------------------
  910-  927 (22.98/25.35)	GDAYSFHYTTGdirdTSN
  933-  946 (28.00/17.65)	GDAMSPPQSTG....TSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.65|      28|     121|     999|    1026|       4
---------------------------------------------------------------------------
  999- 1026 (50.62/35.41)	PVT.Y......YALC..PDI.......DMLTSAATDFFMQLGTI
 1048- 1085 (25.03/13.11)	PGK.YlpsglvLVEC..PDQlktrgshSVSISSVTEYFQAL...
 1122- 1152 (38.00/24.41)	PCTvI......YVVCpfPEP.......SAVLQALVESSVALGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      14|     120|     425|     466|       6
---------------------------------------------------------------------------
  409-  423 (22.26/30.38)	SEFGDFsDFFQGDEL
  442-  455 (27.06/20.12)	SEYGDM.PFIDSPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.43|      49|      49|     277|     325|       7
---------------------------------------------------------------------------
  239-  274 (57.95/38.26)	.............VHQAFVRFSSKRMWSQDW..MGSSSWEAWPFWNFSPSS
  277-  325 (80.00/56.59)	RNSSFFGSSRGLGVNSNFLRLRRQRNNNSNG..MASSISSVSSTSNGSEHA
  329-  374 (65.48/44.52)	KGGDLLADADSTACHQSDLPL....NNDIAGskMVSK.RSRSEITEDSSHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.31|      41|      54|    1651|    1696|      12
---------------------------------------------------------------------------
 1651- 1696 (63.23/60.77)	SPPLAHLLHSKGTAtplamGYVVSKAVPPV.RKNAAQLTKEDRHSVL
 1707- 1748 (67.08/50.32)	STPTVQEKMSRGVG.....GSTMSKQARNItHETSARDYEMDMHNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.80|      17|     122|     558|     578|      17
---------------------------------------------------------------------------
  558-  577 (25.96/31.16)	CGFSSrvySYDVTQSSKVES
  597-  613 (29.84/17.20)	VGRSS...LYTLVQGRKNES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24068 with Med13 domain of Kingdom Viridiplantae
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