<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24062

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQSEGLLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHSPRSVGEGLPVIVAPSGMLGRLVGCCPSDLAIQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKEEFDSVKEPHVGDYGQKKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNNNSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEDSSHAGKEVRENMQGTNGQGGCSWGWGEEGVVMDINILLSEFGDFSDFFQGDELDFGEPPGTAESHALVSPASEYGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKESIPARLSSDVDHDMYDRSQLENVGVWRSVVVPKGAKPLDSLSAKTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRDTSNSIPIGGDAMSPPQSSNDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHLPQHSGGQIEHSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTVNISTNQKESSNIPCTVIYVVCPFPEPSAVLQALVESSVALGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSMSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDMMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSATSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLMATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPMCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIIDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYPERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGDLA
Length1906
PositionKinase
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.08
Grand average of hydropathy-0.297
Instability index59.58
Isoelectric point5.77
Molecular weight208043.97
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24062
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.59|      22|      54|     337|     358|       1
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  337-  358 (42.52/27.48)	VHQAFVRFSSKRMWSQDWMGSS
  388-  409 (38.08/23.74)	VNSNFLRLRRQRNNNSNGMASS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.59|      52|      54|     500|     552|       2
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  500-  552 (88.50/42.46)	MDI.NILLSEFGdFSDF..FQGDELDFGEPPGTAESHALVSPASEYGDMPFIDSPS
  555-  609 (79.09/34.36)	MDIpEQRLSPVG.FTSMeaFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.86|      89|     123|    1236|    1358|       3
---------------------------------------------------------------------------
 1236- 1354 (114.89/142.74)	PSAVLQALVESsvALGSILSSERErksFLYTQVAKALDSSASADEAsasnVVMLSGFSIPKLVLQ...IVTVETLLRLHKPNeLAAFkdiaftvynkarriprfvsmSDMFQSPTYMSRPQS
 1364- 1455 (156.97/100.47)	PTLWKECLVPR..MSGQTLSRETE...FDASMRSVSWDNSWQPGRA....VGLPDPSKIPELCAQddrKYAFEPLFILAEPG.TADY....................SDMMESSRFGADASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.50|      66|     120|     140|     213|       4
---------------------------------------------------------------------------
  140-  213 (94.72/98.22)	LRGLSYarFGDVFTKYNPPTRNQNSfRRAQPTVEFVFAATEEAifvHViiSARYMRNLSSDD....IEKVLTHSPRSV
  263-  332 (107.78/80.96)	LRGQSY..YVEVALGFPPASTDKIS.ESENNQIKEEFDSVKEP...HV..GDYGQKKLESADglpvLERTFIYPPEAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     242.48|      52|     123|     993|    1044|       5
---------------------------------------------------------------------------
  993- 1044 (87.90/54.92)	DWCRGRSNIAESAAMGDAYSF..HYTTGDIRDTSNS.IPIGGDAMSPPQSSNDRG
 1048- 1101 (77.19/47.17)	EHHKGYHRVRPTIAVLPSPSLlvGYQDDWLKTSANC.LKLWEKAPLEPYASAKPV
 1119- 1170 (77.39/47.32)	DFFMQLGTIYEVCKLGTHLPQ..H.SGGQIEHSPGKyLPSGLVLVECPDQLKTRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.31|      41|      54|    1752|    1797|       6
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 1752- 1797 (63.23/56.47)	SPPLAHLLHSKGTAtplamGYVVSKAVPPV.RKNAAQLTKEDRHSVL
 1808- 1849 (67.08/46.76)	STPTVQEKMSRGVG.....GSTMSKQARNItHETSARDYEMDMHNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.53|      48|     961|     660|     778|      11
---------------------------------------------------------------------------
  729-  778 (79.23/119.43)	RPVSGE...TSFSSSLTIQK....KSDSMLNVGYFLLSMKTalATEIECITFQAAMC
 1693- 1747 (75.31/18.90)	RPTSGEgnqSSTGSSSYLDGfapvKSIGSMSASYLLVPSPS..MRYLSPATLQLPMC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24062 with Med13 domain of Kingdom Viridiplantae
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