<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24054

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIEGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHLPQHSGGQIEHSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTVNISTNQKESSNIPCTVIYVVCPFPEPSAVLQALVESSVALGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSMSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDMMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSATSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLMATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPMCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIIDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYPERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGDLA
Length866
PositionKinase
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.238
Instability index63.96
Isoelectric point6.63
Molecular weight94955.86
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24054
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.82|      90|     173|     397|     507|       1
---------------------------------------------------------------------------
  300-  396 (151.62/85.74)	SDMFQSPTYMSRPQSTMMHTASPGPTlwKECLVPRMSGQtlsrETEFDASMR.SVSWDNSWQPGRAV.....G.LPDPSKIP..ELCAQDDRKyAFEPLFI.LAEPG
  401-  500 (135.20/111.98)	SDMMESSRFGADASSSRAYSSISGGT..DSGASPPLEGS....ENDSATSLHcCYGWTEDWRWLVCIwtdsrGeLLDSLIFPfgGISSRQDTK.VLQSLFIqILQQG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.31|      41|      54|     712|     757|       2
---------------------------------------------------------------------------
  712-  757 (63.23/49.83)	SPPLAHLLHSKGTAtplamGYVVSKAVPPV.RKNAAQLTKEDRHSVL
  768-  809 (67.08/41.34)	STPTVQEKMSRGVG.....GSTMSKQARNItHETSARDYEMDMHNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.25|      36|     110|     556|     593|       3
---------------------------------------------------------------------------
  556-  593 (58.39/41.26)	SIPDGI.PSNSNGpTLQQQDMgLIQDRNMPS.SPSTLYSP
  668-  705 (56.86/30.98)	SYLDGFaPVKSIG.SMSASYL.LVPSPSMRYlSPATLQLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.54|      32|     383|     123|     155|       4
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  123-  155 (50.78/51.63)	PDQLKTRgSHSVSISSVTEYFQALSKSW..SVKSF
  508-  541 (49.76/43.45)	PEASNTR.SRDVIITRIGGFLELEIQEWqkAIYSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.64|      26|     610|       1|      39|       8
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   14-   39 (48.01/45.11)	HRVR..PTIAVLPSPSLLVGYQDDWLKT
  625-  652 (39.64/14.57)	HLVRsiSLVAVSQDSSLHLACQADLMAT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24054 with Med13 domain of Kingdom Viridiplantae
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