<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24005

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGTVARQAAEESYLALRELVEKSRAGAEGEVAQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLLHYCQQLASTLSSHETCFIQTGDSLFFMHEGLQQARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERKPTLKKLSTLVRAKLLETLVPKEMSEVSVTDGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGENTGPIKLEETRRYVLGDDIERRMAVADNPLTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGFRIPGLKINYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEAIILKAIACNRHTRLLEIQRELKKNTRISRSPTDVVLKRKEVHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKRSITPTEVFVSLKTRSILQLFAATGRFLGVKVYSECQITLKIPKSILYGSDFMVMGFPWRTNAYYLLMQLDDNLMPVFYLLEVHIDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECIANLLDVEKLQVLQSMEDGSPGHSEIDESLPLKPSFSSVVNAVLGYERDSPSKENWLSYSSPSTHLSSQKVGRQGVSSRAGPPELDDELLHSNIDTAKVASGVTLDSYLLSNSKSANSTETSVSVPAGLENISALRSEVPSGKRYLSEFLLNIPSLQRSIISGGPRKRRKLPEDASSVQSRTTLTYGTILREGNCCITENIYASVLLQVIKHCSLRIKYAQLTTQMNSLNIPYVEEVGLGTPSSNLWLRLPFAQDGSWKHTCLRLGEAGSMSWGVRINDPYYGALWELHGGSNTTEWGSHVRIANTSEMDSHISFDYDGVTLTYNSVEADSIQRLVSELRRLSNARVFACGMRRLVRIKVDEKLVENQLATKAKLHARKGFRNRLSDQMAKNFRINAVGLMNLWFSYGANAMPMVHFVVEWDASKAGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTAGPLLSLGGAIRPAKMPAVPAVCGSAQKQNNVLLANGSSSTTVHINSHDAQTSSMLSAVGWTGHGLVPSSLMPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSIGGSLPCPQFRPFIMEHVAQGLNTLEPSFLNARHTSANTSSGSQQIAASVSRAGNATLPSGDGAPAHLSPDTNLPVHMKGELNTAFIGLGDDGGYGGGWVPHAALKKVLRGILKYLGVLWLFAQLRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLHLQVLNVKRFHHQQQQQQAPQSSAQGELTPSEIHEICDYFSRCVVCEPYDASRIASFIMLLTLPISVIQEFVKLITWNKSLSEAHGDIAAAERARAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHVRTSGGAAWLPFCVSLRLRYTFGDTSHIAYLAMDGSHGGRSCWLQHEDWERCKQSVVKAVKMVNGSPAGGETSRGRLQMVAEMVQKQLQLCLVHLRDGSLSAGSTRP
Length1625
PositionTail
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index50.33
Isoelectric point7.05
Molecular weight180286.61
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24005
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.45|      73|     117|    1083|    1163|       1
---------------------------------------------------------------------------
 1083- 1163 (111.03/106.03)	GPllSLGGAI.....RPAKMPAVPAvcGSAQKQNNVLLANGSSSTTvhiNSHDAQTSSMLSAVG....WTGHGlVPSSLMP.FDVSVVLRG
 1198- 1280 (115.42/82.41)	GP..SIGGSLpcpqfRPFIMEHVAQ..GLNTLEPSFLNARHTSANT...SSGSQQIAASVSRAGnatlPSGDG.APAHLSPdTNLPVHMKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     263.27|      66|     117|     626|     693|       2
---------------------------------------------------------------------------
  626-  693 (103.28/67.09)	EKLQVLQSmEDGSpGHSEIDESLPLK.PSFS.SVVNAV.........LGYERDSPSKENWLSYS...SPSTHLSSQKVGRQG
  748-  811 (92.46/51.44)	ENISALRS.EVPS.GKRYLSEFLLNI.PSLQrSIISG...........GPRKRRKLPEDASSVQ...SRTT.LTYGTILREG
  823-  887 (67.52/35.53)	VLLQVI.K.......HC....SLRIKyAQLT.TQMNSLnipyveevgLG....TPSSNLWLRLPfaqDGSWKHTCLRLGEAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.34|      18|     118|     583|     600|       3
---------------------------------------------------------------------------
  583-  600 (31.62/21.36)	IDGE.DRSNIDTTTDAKEV
  703-  721 (26.72/16.84)	LDDElLHSNIDTAKVASGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.55|      15|      17|     940|     954|       8
---------------------------------------------------------------------------
  940-  954 (24.85/14.86)	LTYNSVEADSIQRLV
  960-  974 (26.69/16.50)	LSNARVFACGMRRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.04|      10|      15|     347|     357|       9
---------------------------------------------------------------------------
  347-  357 (13.30/12.71)	SPFIkVEALQD
  365-  374 (17.74/11.03)	SSFV.LDPLTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.22|      28|     261|    1285|    1314|      11
---------------------------------------------------------------------------
 1285- 1314 (45.17/38.20)	AFIGLgdDGGYGG..GWV...PHAALKKVLRGILK
 1316- 1338 (21.75/ 9.90)	..LGV..........LWLfaqLRDILKDILGSVLK
 1547- 1576 (49.29/33.91)	AYLAM..DGSHGGrsCWL...QHEDWERCKQSVVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24005 with Med14 domain of Kingdom Viridiplantae
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