<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23996

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGTVARQAAEESYLALRELVEKSRAGAEGEVAQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLLHYCQQLASTLSSHETCFIQTGDSLFFMHEGLQQARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERKPTLKKLSTLVRAKLLETLVPKEMSEVSVTDGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGENTGPIKLEETRRYVLGDDIERRMAVADNPLTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGFRIPGLKINYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEAIILKAIACNRHTRLLEIQRELKKNTRISRSPTDVVLKRKEVHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKRSITPTEVFVSLKTRSILQLFAATGRFLGVKVYSECQITLKIPKSILYGSDFMVMGFPWRTNAYYLLMQLDDNLMPVFYLLEVHIDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECIANLLDVEKLQVLQSMEDGSPGHSEIDESLPLKPSFSSVVNAVLGYERDSPSKENWLSYSSPSTHLSSQKVGRQGVSSRAGPPELDDELLHSNIDTAKVASGVTLDSYLLSNSKSANSTETSVSVPAGLENISALRSEVPSGKRYLSEFLLNIPSLQRSIISGGPRKRRKLPEDASSVQSRTTLTYGTILREGNCCITENIYASVLLQVIKHCSLRIKYAQLTTQMNSLNIPYVEEVGLGTPSSNLWLRLPFAQDGSWKHTCLRLGEAGSMSWGVRINDPYYGALWELHGGSNTTEWGSHVRIANTSEMDSHISFDYDGVTLTYNSVEADSIQRLVSELRRLSNARVFACGMRRLVRIKVDEKLVENQLATKAKLHARKGFRNRLSDQMAKNFRINAVGLMNLWFSYGANAMPMVHFVVEWDASKAGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTAGPLLSLGGAIRPAKMPAVPAVCGSAQKQNNVLLANGSSSTTVHINSHDAQTSSMLSAVGWTGHGLVPSSLMPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSIGGSLPCPQFRPFIMEHVAQGLNTLEPSFLNARHTSANTSSGSQQVDTTMNRLSGGTPGEIKLTSGVGCQIAASVSRAGNATLPSGDGAPAHLSPDTNLPVHMKGELNTAFIGLGDDGGYGGGWVPHAALKKVLRGILKYLGVLWLFAQLRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLHLQVLNVKRFHHQQQQQQAPQSSAQGELTPSEIHEICDYFSRCVVCEPYDASRIASFIMLLTLPISVIQEFVKLITWNKSLSEAHGDIAAAERARAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHVRTSGGAAWLPFCVSLRLRYTFGDTSHIAYLAMDGSHGGRSCWLQHEDWERCKQSVVKAVKMVNGSPAGGETSRGRLQMVAEMVQKQLQLCLVHLRDGSLSAGSTRP
Length1650
PositionTail
OrganismAegilops tauschii subsp. strangulata (Goatgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Aegilops.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index49.38
Isoelectric point7.05
Molecular weight182790.42
Publications
PubMed=25035499
PubMed=29158546

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23996
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.88|      49|     117|     626|     693|       1
---------------------------------------------------------------------------
  626-  675 (79.90/49.24)	EKlQVLQS.MEDGSPGHSEIDESLPLKPSFSSVVNAVLGYERDSPSKENWL
 1283- 1325 (72.45/41.59)	.....LPS..GDGAPAHLSPDTNLPVHMK.GELNTAFIGLGDDGGYGGGWV
 1354- 1386 (39.53/24.69)	LK.DILGSvLKDNEGALLNLDQEQPALRFF......VGGY...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.31|      15|      15|     504|     518|       2
---------------------------------------------------------------------------
  504-  518 (23.56/14.50)	TEVFVSLKTRSILQL
  522-  536 (26.75/17.43)	TGRFLGVKVYSECQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      16|      19|     747|     762|       3
---------------------------------------------------------------------------
  747-  762 (27.85/20.21)	LENISAL.RSEVPSGKR
  768-  784 (24.71/16.87)	LLNIPSLqRSIISGGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.34|      18|     117|     583|     600|       4
---------------------------------------------------------------------------
  583-  600 (31.62/20.59)	IDGE.DRSNIDTTTDAKEV
  703-  721 (26.72/16.26)	LDDElLHSNIDTAKVASGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.48|      21|     117|     882|     908|       5
---------------------------------------------------------------------------
  857-  878 (36.73/12.91)	LGTPSSNLW.LRL..PFaQDGSWK.H
  883-  907 (28.74/31.81)	LGEAGSMSWgVRIndPY.YGALWElH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.32|      32|     231|    1155|    1219|      10
---------------------------------------------------------------------------
 1155- 1190 (52.72/86.42)	FDVSVVLRGPY..WIRIIYrnkFSVDmRCFAGDQVWLQ
 1555- 1588 (57.60/22.09)	FCVSLRLRYTFgdTSHIAY...LAMD.GSHGGRSCWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.30|      35|     281|    1226|    1266|      21
---------------------------------------------------------------------------
 1226- 1266 (53.61/56.81)	EPSFL...NARHTSANTSsgsqqVDTTMN.RLSGGTPGEIKlTSG
 1510- 1548 (54.69/39.18)	EPSLLsksNIQHDRANNS.....VDFTLTfVLDHNLTPHVR.TSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23996 with Med14 domain of Kingdom Viridiplantae
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