<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23848

Description Mediator of RNA polymerase II transcription subunit 16
SequenceTMDLAYICEWEKWPKSTHCPSGPLACTWSCRNLIAFTTDLRSDDQDLTRMIHILDTEHPWDVHSIRSEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESPVGSVVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQLYKVCVSVVNEKCRIDTELLPSLFMRCTTDLSRRDRLPAITHLKFLARDMSEQVLLCASSQTSSVVECWSLRKEGLPVNNIFQQLSPAVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAIFYSSAAPRPVDEPALKRPRTTGPTVHFKAMQLSWTSLALVGIDNHGRLSMLRISPSMGHSLDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHEEYTRQKAELQQVLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPALPGGSSSLQLDGLIRVPGQPKMDHLRRLHLGAYPTEACKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGTPVTDRASEDTLAPQPSHRGSFSLEAC
Length847
PositionTail
OrganismCapra hircus (Goat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Capra.
Aromaticity0.06
Grand average of hydropathy-0.002
Instability index49.48
Isoelectric point7.26
Molecular weight93488.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23848
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.35|      38|      96|     420|     464|       1
---------------------------------------------------------------------------
  420-  464 (54.06/48.45)	FKA..MQLSWTSLALVgIDNHGRLSMLRISPSMgHSLdvglaLR.HLL
  518-  558 (59.30/33.07)	MKAslCKLSPCTVTRV.CDYHAKLFLIAISSTL.KSL.....LRpHVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.18|      59|     195|      66|     125|       2
---------------------------------------------------------------------------
   66-  125 (103.54/66.12)	RSEHSEAITCLEW...DQSGSRLL..SADADGQIKCWSMADH...LANSWESPVGSVVEGDPIVaLSW
  262-  328 (88.64/52.24)	RRDRLPAITHLKFlarDMSEQVLLcaSSQTSSVVECWSLRKEglpVNNIFQQLSPAVGDKQPTI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.82|      24|     125|     686|     712|       5
---------------------------------------------------------------------------
  686-  712 (45.46/32.06)	WI..C.CrdeGPTSEPDEALVDECCLLPSQ
  812-  838 (40.36/21.05)	WIknClC...GGTPVTDRASEDTLAPQPSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.11|      12|     473|     181|     192|       7
---------------------------------------------------------------------------
  181-  192 (22.09/13.47)	LLKPSG.QVLTST
  656-  668 (20.03/11.47)	LLKPSClPVYTAT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23848 with Med16 domain of Kingdom Metazoa
Unable to open file!