<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23820

Description Mediator of RNA polymerase II transcription subunit 12 isoform A
SequenceMQRYHAGSCTSAVNNSTIGGPSARDPGRSDSPSLPANFAVSSRRQLPLNPYKLKCDKEPLNSRLGAPDFHPQTPNCPEETLTREYLQSGYRDTVEGLEEAREISLTQVPHFNKNIVLKCKEAIRKRLRAINESRAQKRKAGQVYGVALSGSQLGRSGIFPELRPCGEDFQKKWIEGLSQQHKRLRSLADHVPHGYKRASLLEVLIKNNVPLLRATWFIKVTYLNQVRPGSVGISSGAADKIQLSRSDVWTKDVINYLQTLVDEFLSKNALHSASHGRERSPQIPYTGSLQNKNDPLLSVSDGEGPSLHFRWWYIVRLLQWHHAEGLLHSSLVIDWVFNQLQEKELLEVWQLLLPIIYGFLETIVLSQSYVRTLAGLALRVIRDPAPGGSDLVDNSRRAYTAYAVVEMLRYLILVVPDTFAALDCFPLPSSVISHTMNDGSFVLKSTEAAGKIKNSSDDFGHIISCIQKHTEDLAKSASPGYPGHCLAKVAKALDKSLVLGDLRVAYKFLFEELCGGTVSEGWVSKVSPCLRLSLKWFGTVNTALIYSVFFLCEWATCDFRDFRSTPPRDIKFTGRKDLSQVHIAVRLLLMKIRDVKISQKQTNENHRASHLAKNSSQCQNWNYVGNVSRSKSSSKSMGSSVFESPGPLHDIIVCWIDQHVVHKGEGPKRLHLFMVELIRAGIFYPLAYVRQLIVSGIMDVYVNVVDLERWRRHYRILKQLPGCFIHDVLEESGIVEGPQLKEALQIYLNERRLILRGPLSMSHDDANGSNLSALKKKKYPASTKDEVSAVPIDQRNVISTTISSKSAKDNANIEELRTAISVLLQLPNCSSNLSTTGDESEGSVRRPIGSPYSKIDPVEGTPGCEECSRAKRQKLSEERSSFVQGHSPVQSDDDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQKNVRKTQSLAQLAASRIESSQGASTSHVCGNKVSCPHHKTAMDGEGQRSVDCIQTSHFGDIVSIGKALKQLRFVEKRALAVWLLTVVRQVIEEVEKNIGKVGQFGRPFPVADDRGSIRWKLGEDELSVILYLMDISDDLVSAVKFLLWLLPKVLNSPNSTIHSGRNVLMLPRNVENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMHRAATVIASIGRVSGSGALAFARYLLRKYSNVASVIEWEKTFKTTSDARLSSELESGGSVDGELGLPLGVPAGVKDHDDFFRQKISGGRLPSRVGAGMRDIVQRNVEEAFHYLFGKDRKLFAAGTPKGPALEKWDNGYQIAHQIVMGLIDCIRQTGGAAQEGDPSLVSSAVSAIVGSVGPTLAKMPDFSSGNNHSNIMSATNSLNYARCILRMHITCLCLLKEALGERQSRVFDIALATEASNALAGVFTPSKASRSQFQMSPEAHDSSNTISNDMGSNSIKVVAKTTKIAAAVSALLVGAIVYGVTSLERMVAVLRLKEGLDVAQFVRNARSNSNGNARSVMAFKVDSSIEGHVHWFRLLVGNCRTICEGLVVELLGEPSIMALSRMQLMLPLNLVFPPAYSIFAFVRWRPFMLNATVREDMNQIYQSLSMAITDAIKHLPFRDVCFRDCQGLYDLMAADASDSELATLLEFNGSDMHLKSTAFVPLRSRLFLNAMIDCKMPPSIYTKDDGSRMSGLGESKIKFTDSESKLQDLLVHVLDTLQPAKFHWQWVVLRLLLNEQALVERLENRDVSLVDAIKLSSPSTEKASAASENENNFIQILLTRLLVRPDAAPLFSELIHLFGRSLEDSMLLQGKWFLAGQDVLFGRKTIRQRLHNIAMKKNLSVKTQFWEPWGWCSPSTDPLTIKGDNKKFDSTSLEEGEVVEEGMDLKRCQQQVTERALIELLLPCIDQSSDESRNSFASDMMKQLSYIEQQITAVTGGSKPVGSAPPGVEGQPNKVNNRKNMRGGGPALARRQTVAADSSPPSPAALRASMSLRLQLLLRFLPILCTDREPSVRSMRQFLATVIFRLLGSRVVHVDADISVNAVPFLPIREAESSSEVASAAFVDSSSGSLFDRLLLVLHGLLSSYPPSWLRAKPVSKTISEPTREFSGIDRELLEALQNDLDRMQLPDTIRWRIQAAMPMLIPSMRCSLSCQPPSVSNSALVCLQPSITNPGSNSSSSTIPQRNSVLSRVASNASGKSKLQDNDLEIDPWTLLEDGAGSYPSAGNTASIVSGDHANIRATSWLKGAVRVRRTDLTYVGAVDDDS
Length2227
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index48.92
Isoelectric point8.87
Molecular weight246087.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23820
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.34|      90|     777|     425|     527|       1
---------------------------------------------------------------------------
  425-  527 (132.22/131.35)	FPL..PSSVISHtmnDGSFVLKSTeaAGKIKnSSDDFGhIISCIQKHTED.....LAKSA...SPGYP.GHCLAKVAKA..LDKSLVLGDLRVAYKflfeelCGGTVSEGWVSKVS
 1203- 1305 (136.13/96.04)	LPLgvPAGVKDH...DDFFRQKIS..GGRLP.SRVGAG.MRDIVQRNVEEafhylFGKDRklfAAGTPkGPALEKWDNGyqIAHQIVMGLIDCIRQ......TGGAAQEGDPSLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.99|      38|     777|      13|     107|       2
---------------------------------------------------------------------------
   59-  106 (50.73/32.02)	PLNSRLgapdFHPQTPNC..PEETLTREylqSGYRdtVEGLEEAReISLT
 1624- 1663 (66.26/36.57)	PLRSRL....FLNAMIDCkmPPSIYTKD...DGSR..MSGLGESK.IKFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.47|      47|     777|     984|    1038|       3
---------------------------------------------------------------------------
  333-  363 (36.22/14.68)	IDWVFNQLQ..EKELLEVWqlLLPIIYGFLETI........................
  990- 1038 (75.54/64.91)	IGKALKQLRfvEKRALAVW..LLTVVRQVIEEV..EKNIGKVGQFGRPF....PVAD
 1789- 1820 (26.72/ 9.87)	.........................IRQRLHNIamKKNLSVKTQFWEPWgwcsPSTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.46|      18|     361|     299|     319|       4
---------------------------------------------------------------------------
  299-  319 (28.66/24.30)	VSDGEGPS.LHFrwwYIVRLLQ
  661-  679 (29.79/14.50)	VHKGEGPKrLHL...FMVELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.88|      31|     777|      13|      47|       5
---------------------------------------------------------------------------
   13-   43 (56.64/34.37)	VNNSTI..GGPSARDPG.RSDSPSLPANFAVSSR
 2119- 2152 (45.23/18.19)	VSNSALvcLQPSITNPGsNSSSSTIPQRNSVLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.96|      32|     777|    1378|    1452|       6
---------------------------------------------------------------------------
  793-  824 (51.01/12.34)	DQRNVISTTISSKSAKDNANIEELRTAISVLL
 1404- 1435 (50.96/ 8.81)	DSSNTISNDMGSNSIKVVAKTTKIAAAVSALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.84|      55|     583|    1316|    1376|      16
---------------------------------------------------------------------------
 1316- 1376 (80.22/74.84)	GPTLAKMPDFSSGNNHSN..IMSATNSLNYaRCILRMhITCLCLLKEAlGERQSRVFdiaLAT
 1928- 1984 (89.63/59.81)	GPALARRQTVAADSSPPSpaALRASMSLRL.QLLLRF.LPILCTDREP.SVRSMRQF...LAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.42|      62|     430|    1075|    1140|      17
---------------------------------------------------------------------------
 1075- 1140 (96.56/95.06)	LLPKVLNSPnSTIHSGRNVLMLPRN.VENQVCDVgeaFLLSSLRRYE.NILVAADL..IPEALSSAMHRA
 1509- 1574 (96.86/79.73)	LVVELLGEP.SIMALSRMQLMLPLNlVFPPAYSI...FAFVRWRPFMlNATVREDMnqIYQSLSMAITDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23820 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSEERSSFVQGHSPVQSDDDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQK
2) SCTSAVNNSTIGGPSARDPGRSDSPSLPANFAVS
3) SNLSTTGDESEGSVRRPIGSPYSKIDPVEGTPGCEECSRAKR
4) TGGSKPVGSAPPGVEGQPNKVNNRKNMRGGGPALARRQTVAADSSPPS
875
8
831
1898
927
41
872
1945










Molecular Recognition Features






MoRF SequenceStartStop




1) AWWVK
896
900