<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23817

Description Mediator of RNA polymerase II transcription subunit 12 isoform D
SequenceMQRYHAGSCTSAVNNSTIGGPSARDPGRSDSPSLPANFAVSSRNCKFQIFVVERDSVESAIKPKERKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKGVESAIKPKERKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKGASQVRTAMLHFYSTSNVVKIEISRDRKGDERLRQLPLNPYKLKCDKEPLNSRLGAPDFHPQTPNCPEETLTREYLQSGYRDTVEGLEEAREISLTQVPHFNKNIVLKCKEAIRKRLRAINESRAQKRKAGQVYGVALSGSQLGRSGIFPELRPCGEDFQKKWIEGLSQQHKRLRSLADHVPHGYKRASLLEVLIKNNVPLLRATWFIKVTYLNQVRPGSVGISSGAADKIQLSRSDVWTKDVINYLQTLVDEFLSKNALHSASHGRERSPQIPYTGSLQNKNDPLLSVSDGEGPSLHFRWWYIVRLLQWHHAEGLLHSSLVIDWVFNQLQEKELLEVWQLLLPIIYGFLETIVLSQSYVRTLAGLALRVIRDPAPGGSDLVDNSRRAYTAYAVVEMLRYLILVVPDTFAALDCFPLPSSVISHTMNDGSFVLKSTEAAGKIKNSSDDFGHIISCIQKHTEDLAKSASPGYPGHCLAKVAKALDKSLVLGDLRVAYKFLFEELCGGTVSEGWVSKVSPCLRLSLKWFGTVNTALIYSVFFLCEWATCDFRDFRSTPPRDIKFTGRKDLSQVHIAVRLLLMKIRDVKISQKQTNENHRASHLAKNSSQCQNWNYVGNVSRSKSSSKSMGSSVFESPGPLHDIIVCWIDQHVVHKGEGPKRLHLFMVELIRAGIFYPLAYVRQLIVSGIMDVYVNVVDLERWRRHYRILKQLPGCFIHDVLEESGIVEGPQLKEALQIYLNERRLILRGPLSMSHDDANGSNLSALKKKKYPASTKDEVSAVPIDQRNVISTTISSKSAKDNANIEELRTAISVLLQLPNCSSNLSTTGDESEGSVRRPIGSPYSKIDPVEGTPGCEECSRAKRQKLSEERSSFVQGHSPVQSDDDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQKNVRKTQSLAQLAASRIESSQGASTSHVCGNKVSCPHHKTAMDGEGQRSVDCIQTSHFGDIVSIGKALKQLRFVEKRALAVWLLTVVRQVIEEVEKNIGKVGQFGRPFPVADDRGSIRWKLGEDELSVILYLMDISDDLVSAVKFLLWLLPKVLNSPNSTIHSGRNVLMLPRNVENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMHRAATVIASIGRVSGSGALAFARYLLRKYSNVASVIEWEKTFKTTSDARLSSELESGGSVDGELGLPLGVPAGVKDHDDFFRQKISGGRLPSRVGAGMRDIVQRNVEEAFHYLFGKDRKLFAAGTPKGPALEKWDNGYQIAHQIVMGLIDCIRQTGGAAQEGDPSLVSSAVSAIVGSVGPTLAKMPDFSSGNNHSNIMSATNSLNYARCILRMHITCLCLLKEALGERQSRVFDIALATEASNALAGVFTPSKASRSQFQMSPEAHDSSNTISNDMGSNSIKVVAKTTKIAAAVSALLVGAIVYGVTSLERMVAVLRLKEGLDVAQFVRNARSNSNGNARSVMAFKVDSSIEGHVHWFRLLVGNCRTICEGLVVELLGEPSIMALSRMQLMLPLNLVFPPAYSIFAFVRWRPFMLNATVREDMNQIYQSLSMAITDAIKHLPFRDVCFRDCQGLYDLMAADASDSELATLLEFNGSDMHLKSTAFVPLRSRLFLNAMIDCKMPPSIYTKDDGSRMSGLGESKIKFTDSESKLQDLLVHVLDTLQPAKFHWQWVVLRLLLNEQALVERLENRDVSLVDAIKLSSPSTEKASAASENENNFIQILLTRLLVRPDAAPLFSELIHLFGRSLEDSMLLQGKWFLAGQDVLFGRKTIRQRLHNIAMKKNLSVKTQFWEPWGWCSPSTDPLTIKGDNKKFDSTSLEEGEVVEEGMDLKRCQQQVTERALIELLLPCIDQSSDESRNSFASDMMKQLSYIEQQITAVTGGSKPVGSAPPGVEGQPNKVNNRKNMRGGGPALARRQTVAADSSPPSPAALRASMSLRLQLLLRFLPILCTDREPSVRSMRQFLATVIFRLLGSRVVHVDADISVNAVPFLPIREAESSSEVASAAFVDSSSGSLFDRLLLVLHGLLSSYPPSWLRAKPVSKTISEPTREFSGIDRELLEALQNDLDRMQLPDTIRWRIQAAMPMLIPSMRCSLSCQPPSVSNSALVCLQPSITNPGSNSSSSTIPQRNSVLSRVASNASGKSKLQDNDLEIDPWTLLEDGAGSYPSAGNTASIVSGDHANIRATSWLKGAVRVRRTDLTYVGAVDDDS
Length2384
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.266
Instability index48.53
Isoelectric point8.98
Molecular weight263854.70
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23817
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.24|      55|      55|      58|     112|       1
---------------------------------------------------------------------------
   24-   56 (27.22/12.07)	........................RDPGRSDsPSLPANFAVSSRNCKFQIFVVERdS
   58-  112 (114.01/79.04)	ESAIKPKERKEQSSGAETEQRTEDKTPGKGH.RGLQAFWKLSQPGQKKPEILLEK.G
  114-  168 (114.01/79.04)	ESAIKPKERKEQSSGAETEQRTEDKTPGKGH.RGLQAFWKLSQPGQKKPEILLEK.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     703.79|     228|     360|     987|    1226|       2
---------------------------------------------------------------------------
  987- 1226 (360.96/268.63)	SSNLsTTGDESEGSVRRPIGSPYSKID.......PVEG..TPG.CEECSRAKRQKLSEERSSFVQGHspvqsddDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQKNVRKT........QSLAQLAASRIESSQGASTSHVcGNKVSCPHHKTAMDGEGQRS.VDCIQTSHFGDIVSIGKALKQlRfvEKRALAVWLLTVVRQVIEEV.EKNIGKVGQFGRPFPVADDRGSIRWKLGEDELSVILYLMDI....SDDLVSAV
 1345- 1596 (342.83/223.58)	SSEL.ESGGSVDGELGLPLGVPAGVKDhddffrqKISGgrLPSrVGAGMRDIVQRNVEEAFHYLFGK.......DRKLFAAGTPKGPALEKWDNGYQIAHQIVMGLIDCIRQTggaaqegdPSLVSSAVSAIVGSVGPTLAKM.PDFSSGNNHSNIMSATNSLNyARCILRMHITCLCLLKEALGE.R..QSRVFDIALATEASNALAGVfTPSKASRSQFQMSPEAHDSSNTISNDMGSNSIKVVAKTTKIaaavSALLVGAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.97|      39|     361|    1967|    2005|       3
---------------------------------------------------------------------------
 1967- 2005 (73.88/47.55)	EPW.....GWCS.PSTDPLT..IKGDNKKFDSTSLEEGEVVEEGMDL
 2328- 2374 (56.09/34.10)	DPWtlledGAGSyPSAGNTAsiVSGDHANIRATSWLKGAVRVRRTDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.46|      18|     361|     456|     476|       4
---------------------------------------------------------------------------
  456-  476 (28.66/26.19)	VSDGEGPS.LHFrwwYIVRLLQ
  818-  836 (29.79/15.67)	VHKGEGPKrLHL...FMVELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     263.47|      76|     404|    1770|    1845|       5
---------------------------------------------------------------------------
  216-  263 (23.04/ 7.35)	................PLNSRLgapdF..HPQTPNC..PEETLTREylqSGYRdtVEGLEEAReISLT..........................
 1770- 1845 (134.98/81.68)	SDMHLKSTAFV.....PLRSRL....F..LNAMIDCKMPPSIYTKD...DGSR..MSGLGESK.IKFTDSESKLQDLLVHVLDTLQ.PAKFHWQ
 2173- 2253 (105.45/62.07)	SSSEVASAAFVdsssgSLFDRL....LlvLHGLLS.SYPPSWLRAK...PVSK..T..ISEPT.REFSGIDRELLEALQNDLDRMQlPDTIRWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.15|      59|     404|    1235|    1314|       6
---------------------------------------------------------------------------
 1235- 1297 (91.43/87.17)	KVLNSPnSTIHSGRNVLMLPRN.VENQVCDVgeaFLLSSLRRYE.NILVAADL..IPEALSSAMHRA
 1669- 1731 (92.72/48.85)	ELLGEP.SIMALSRMQLMLPLNlVFPPAYSI...FAFVRWRPFMlNATVREDMnqIYQSLSMAITDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.46|      40|    1663|     622|     661|      13
---------------------------------------------------------------------------
  622-  661 (70.75/47.37)	CIQKH.TEDLAKSASPGYP..GHCLAKVA.KALDKS.LVLGDLRV
 2283- 2327 (51.70/32.27)	CLQPSiTNPGSNSSSSTIPqrNSVLSRVAsNASGKSkLQDNDLEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23817 with Med12 domain of Kingdom Viridiplantae
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