<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23815

Description Mediator of RNA polymerase II transcription subunit 12 isoform E
SequenceMQRYHAGSCTSAVNNSTIGGPSARDPGRSDSPSLPANFAVSSRKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKGVESAIKPKERKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKGASQVRTAMLHFYSTSNVVKIEISRDRKGDERLRQLPLNPYKLKCDKEPLNSRLGAPDFHPQTPNCPEETLTREYLQSGYRDTVEGLEEAREISLTQVPHFNKNIVLKCKEAIRKRLRAINESRAQKRKAGQVYGVALSGSQLGRSGIFPELRPCGEDFQKKWIEGLSQQHKRLRSLADHVPHGYKRASLLEVLIKNNVPLLRATWFIKVTYLNQVRPGSVGISSGAADKIQLSRSDVWTKDVINYLQTLVDEFLSKNALHSASHGRERSPQIPYTGSLQNKNDPLLSVSDGEGPSLHFRWWYIVRLLQWHHAEGLLHSSLVIDWVFNQLQEKELLEVWQLLLPIIYGFLETIVLSQSYVRTLAGLALRVIRDPAPGGSDLVDNSRRAYTAYAVVEMLRYLILVVPDTFAALDCFPLPSSVISHTMNDGSFVLKSTEAAGKIKNSSDDFGHIISCIQKHTEDLAKSASPGYPGHCLAKVAKALDKSLVLGDLRVAYKFLFEELCGGTVSEGWVSKVSPCLRLSLKWFGTVNTALIYSVFFLCEWATCDFRDFRSTPPRDIKFTGRKDLSQVHIAVRLLLMKIRDVKISQKQTNENHRASHLAKNSSQCQNWNYVGNVSRSKSSSKSMGSSVFESPGPLHDIIVCWIDQHVVHKGEGPKRLHLFMVELIRAGIFYPLAYVRQLIVSGIMDVYVNVVDLERWRRHYRILKQLPGCFIHDVLEESGIVEGPQLKEALQIYLNERRLILRGPLSMSHDDANGSNLSALKKKKYPASTKDEVSAVPIDQRNVISTTISSKSAKDNANIEELRTAISVLLQLPNCSSNLSTTGDESEGSVRRPIGSPYSKIDPVEGTPGCEECSRAKRQKLSEERSSFVQGHSPVQSDDDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQKNVRKTQSLAQLAASRIESSQGASTSHVCGNKVSCPHHKTAMDGEGQRSVDCIQTSHFGDIVSIGKALKQLRFVEKRALAVWLLTVVRQVIEEVEKNIGKVGQFGRPFPVADDRGSIRWKLGEDELSVILYLMDISDDLVSAVKFLLWLLPKVLNSPNSTIHSGRNVLMLPRNVENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMHRAATVIASIGRVSGSGALAFARYLLRKYSNVASVIEWEKTFKTTSDARLSSELESGGSVDGELGLPLGVPAGVKDHDDFFRQKISGGRLPSRVGAGMRDIVQRNVEEAFHYLFGKDRKLFAAGTPKGPALEKWDNGYQIAHQIVMGLIDCIRQTGGAAQEGDPSLVSSAVSAIVGSVGPTLAKMPDFSSGNNHSNIMSATNSLNYARCILRMHITCLCLLKEALGERQSRVFDIALATEASNALAGVFTPSKASRSQFQMSPEAHDSSNTISNDMGSNSIKVVAKTTKIAAAVSALLVGAIVYGVTSLERMVAVLRLKEGLDVAQFVRNARSNSNGNARSVMAFKVDSSIEGHVHWFRLLVGNCRTICEGLVVELLGEPSIMALSRMQLMLPLNLVFPPAYSIFAFVRWRPFMLNATVREDMNQIYQSLSMAITDAIKHLPFRDVCFRDCQGLYDLMAADASDSELATLLEFNGSDMHLKSTAFVPLRSRLFLNAMIDCKMPPSIYTKDDGSRMSGLGESKIKFTDSESKLQDLLVHVLDTLQPAKFHWQWVVLRLLLNEQALVERLENRDVSLVDAIKLSSPSTEKASAASENENNFIQILLTRLLVRPDAAPLFSELIHLFGRSLEDSMLLQGKWFLAGQDVLFGRKTIRQRLHNIAMKKNLSVKTQFWEPWGWCSPSTDPLTIKGDNKKFDSTSLEEGEVVEEGMDLKRCQQQVTERALIELLLPCIDQSSDESRNSFASDMMKQLSYIEQQITAVTGGSKPVGSAPPGVEGQPNKVNNRKNMRGGGPALARRQTVAADSSPPSPAALRASMSLRLQLLLRFLPILCTDREPSVRSMRQFLATVIFRLLGSRVVHVDADISVNAVPFLPIREAESSSEVASAAFVDSSSGSLFDRLLLVLHGLLSSYPPSWLRAKPVSKTISEPTREFSGIDRELLEALQNDLDRMQLPDTIRWRIQAAMPMLIPSMRCSLSCQPPSVSNSALVCLQPSITNPGSNSSSSTIPQRNSVLSRVASNASGKSKLQDNDLEIDPWTLLEDGAGSYPSAGNTASIVSGDHANIRATSWLKGAVRVRRTDLTYVGAVDDDS
Length2361
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.263
Instability index48.77
Isoelectric point8.98
Molecular weight261149.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23815
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.16|      47|      54|      43|      89|       1
---------------------------------------------------------------------------
   43-   89 (102.08/70.74)	RKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKG
   99-  145 (102.08/70.74)	RKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     703.79|     228|     360|     964|    1203|       2
---------------------------------------------------------------------------
  964- 1203 (360.96/300.56)	SSNLsTTGDESEGSVRRPIGSPYSKID.......PVEG..TPG.CEECSRAKRQKLSEERSSFVQGHspvqsddDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQKNVRKT........QSLAQLAASRIESSQGASTSHVcGNKVSCPHHKTAMDGEGQRS.VDCIQTSHFGDIVSIGKALKQlRfvEKRALAVWLLTVVRQVIEEV.EKNIGKVGQFGRPFPVADDRGSIRWKLGEDELSVILYLMDI....SDDLVSAV
 1322- 1573 (342.83/250.16)	SSEL.ESGGSVDGELGLPLGVPAGVKDhddffrqKISGgrLPSrVGAGMRDIVQRNVEEAFHYLFGK.......DRKLFAAGTPKGPALEKWDNGYQIAHQIVMGLIDCIRQTggaaqegdPSLVSSAVSAIVGSVGPTLAKM.PDFSSGNNHSNIMSATNSLNyARCILRMHITCLCLLKEALGE.R..QSRVFDIALATEASNALAGVfTPSKASRSQFQMSPEAHDSSNTISNDMGSNSIKVVAKTTKIaaavSALLVGAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.97|      39|     361|    1944|    1982|       3
---------------------------------------------------------------------------
 1944- 1982 (73.88/47.56)	EPW.....GWCS.PSTDPLT..IKGDNKKFDSTSLEEGEVVEEGMDL
 2305- 2351 (56.09/34.10)	DPWtlledGAGSyPSAGNTAsiVSGDHANIRATSWLKGAVRVRRTDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.46|      18|     361|     433|     453|       4
---------------------------------------------------------------------------
  433-  453 (28.66/28.32)	VSDGEGPS.LHFrwwYIVRLLQ
  795-  813 (29.79/16.90)	VHKGEGPKrLHL...FMVELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.42|      62|     430|    1209|    1274|       5
---------------------------------------------------------------------------
 1209- 1274 (96.56/67.12)	LLPKVLNSPnSTIHSGRNVLMLPRN.VENQVCDVgeaFLLSSLRRYE.NILVAADL..IPEALSSAMHRA
 1643- 1708 (96.86/56.26)	LVVELLGEP.SIMALSRMQLMLPLNlVFPPAYSI...FAFVRWRPFMlNATVREDMnqIYQSLSMAITDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.46|      40|    1669|     599|     638|       8
---------------------------------------------------------------------------
  599-  638 (70.75/45.62)	CIQKH.TEDLAKSASPGYP..GHCLAKVA.KALDKS.LVLGDLRV
 2260- 2304 (51.70/31.08)	CLQPSiTNPGSNSSSSTIPqrNSVLSRVAsNASGKSkLQDNDLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.21|      65|    1106|     884|     951|      12
---------------------------------------------------------------------------
  884-  951 (95.88/64.39)	ERRLI.LRGP.LSMSHDDANGSNLSALKKKKypASTKDEVSAVPIDQRNVISTT..ISSKSAKDNaNIEELR
 1991- 2059 (96.33/54.45)	ERALIeLLLPcIDQSSDESRNSFASDMMKQL..SYIEQQITAVTGGSKPVGSAPpgVEGQPNKVN.NRKNMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.99|      38|    1557|     193|     240|      13
---------------------------------------------------------------------------
  193-  240 (50.73/58.98)	PLNSRLgapdFHPQTPNC..PEETLTREylqSGYRdtVEGLEEAReISLT
 1758- 1797 (66.26/41.06)	PLRSRL....FLNAMIDCkmPPSIYTKD...DGSR..MSGLGESK.IKFT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23815 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSEERSSFVQGHSPVQSDDDDAWWVKKGMKSPEPLKVDQSQKSTKQVTKIRQK
2) MQRYHAGSCTSAVNNSTIGGPSARDPGRSDSPSLPANFAVSSRKEQSSGAETEQRTEDKTPGKGHRGLQAFWKLSQPGQKKPEILLEKGVESAIKPKERKEQSSGAETEQRTEDKTPGKGHRGLQAFWKL
3) SNLSTTGDESEGSVRRPIGSPYSKIDPVEGTPGCEECSRAKR
4) TGGSKPVGSAPPGVEGQPNKVNNRKNMRGGGPALARRQTVAADSSPPS
1009
1
965
2032
1061
130
1006
2079










Molecular Recognition Features






MoRF SequenceStartStop




1) AWWVK
2) HRGLQAFWK
1030
65
1034
73