<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23810

Description Cyclin-dependent kinase E-1 isoform D
SequenceMGDDSGSNRSKPEWLQQYDLIGKIGEGTYGLVFLARIKSSTNRGKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINHMDMSLYLAFDYAEHDLFEIIRHHRDKVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGEEHGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKATPNPFQLDQLDKIFKVLGHPTLEKWPSLANLPHWQQDSQHIQGHKYDNASLCSVLQLSPKSPAYDLLSKMLEYDPRKRITAAQALEHEYFKIEPLPGRNALVPCQPGDTFVNYPTRPVDTTTDFEGTANMQPSQPVSSGAAVSGNMPGGHVSNRSVPRPMNVGGMQRIPHQAMQGYNLSSQAGMGAGMNPGGIPMQRGVPQQQV
Length442
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.08
Grand average of hydropathy-0.348
Instability index36.31
Isoelectric point8.25
Molecular weight49213.76
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23810
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.98|      26|      28|     384|     409|       1
---------------------------------------------------------------------------
  344-  372 (31.93/17.61)	.PGDTFVNYP..TRPVDTttdfeGT..ANM.QPSQ
  384-  409 (52.35/33.52)	MPGGHVSNRS.VPRPMNV.....GG..MQR.IPHQ
  411-  440 (34.69/19.76)	MQGYNLSSQAgMGAGMNP.....GGipMQRgVPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.27|      22|      31|       5|      27|       2
---------------------------------------------------------------------------
    5-   27 (36.12/25.37)	SGSNRSKPEWLQQYDLiGKIGEG
   39-   60 (37.16/21.64)	SSTNRGKSIAIKKFKQ.SKDGDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      14|      42|     156|     185|       3
---------------------------------------------------------------------------
  145-  167 (18.18/15.32)	IIHRDLKPSnilvmgegeEHGVV
  177-  191 (22.34/24.19)	IYQAPLKPL........sENGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.50|      23|      32|      71|      95|       5
---------------------------------------------------------------------------
   71-   95 (35.64/31.77)	LLREITHENvvKLVNVHINHMDM.SL
  106-  129 (35.86/25.08)	LFEIIRHHR..DKVNQSINQYTVkSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23810 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PCQPGDTFVNYPTRPVDTTTDFEGTANMQPSQPVSSGAAVSGNMPGGHVSNRSVPRPMNVGGMQRIPHQAMQGYNLSSQAGMGAGMNPGGIPMQRGVPQQQV
341
442










Molecular Recognition Features






MoRF SequenceStartStop




1) LVFLARIK
2) RGKSIAIKKFKQ
3) RSKPEWLQQYDLIG
31
43
9
38
54
22