<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23761

Description Mediator of RNA polymerase II transcription subunit 15a isoform E
SequenceMDSNNWRPNQGTNPTMDTSDWRAQLPIDSRQRIVNKIMETLKKHLPVSGPDGLHELRKIAQRFEDKIFTAATSQPDYLRKISLKMLTMETKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLPGQLQPHQQLLSQNVQNNVASQPNLPPVSSLAQTPSQNIVQNSNIQNITGPNSVGTTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSQQYLYQQQFKQKLQLQSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQASSLSSIPQNQQSTNVQQPMQSMPQQHSQVIRHQQQQTSIVHQQQTAVTHQPSLPSQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQQFGNNGPGLQQQHLLGHESGNADMQTSHHSTHMLQQPKVPMQQQSQQNTSNLLLPHSQQPQPLGSQQQLMPQIHTQSAQLQQQLGLQQQPNPSQRDMQQRIQASGSLLQQQNVLDQKKQLYQTQRTLPETSATSLDSTAQTAQPSGADWQEEVYRKLQTMKESYLPEMNEMYQKIANKLQQHDSLPQQPKSDQIDKLRAYKTMLERMMALLQIPKNNILPNFKEKLGSYEKQIINLINSNRPRKGMNSVQAGQLPPTHMSSMQQPQSQVTQVHSHENQMNPQLQSTNLQGSVPTMQQNNIASLQHNALAGVSTGQQNMMNSMQPVTNLDSGHGNSMNSLQQVPMSSLQQNPVSTPQQTNINSLPSQGGANMIQPNALQSGSSALQHQLKHQQEQQMLQSQQFKQQYQQRQQLMQRQQLLQQQQLHHPAKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKAKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKPIPCVSSISNAANIGHQQTGGAIAPAQSLAIGTPGISASPLLAEFSAPDGAHGNALAATSGKSTVTEQPLERLINAVKSMSSKALSAAVMDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVSMTNCRLQARNFITQDGSNGIKRMKRYTSAIPLNVVPSAGSMNDSIKQLTASETSDLESTATSSVKKPKIEVNHALLEEIREINHQLIDTVVDISNEDVDPTAAVAAAEGAEGIIVKCSFIAVALSPSLKSQYASAQMVDSHF
Length1212
PositionTail
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.02
Grand average of hydropathy-0.782
Instability index62.91
Isoelectric point9.31
Molecular weight133662.27
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23761
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     413.37|      45|      45|     299|     343|       5
---------------------------------------------------------------------------
  181-  232 (40.60/ 7.60)	ItgpnsvgttiSQ.................................................NSN.....LQNMFP......GSQRQMPGRQQ....IV....PPQ......N..SQ..QYLY...QQQFKQK
  299-  343 (79.94/24.34)	H..........SQ.......................V.....................I..RHQQ.....QQTSIV......HQQQTAVTHQP....SL....PSQ......Q..QQ..QLMG...HQPNTTN
  346-  417 (42.30/ 8.32)	H..........AQmlgqqnnvgdiqqpqrmlsqqsnL.....................T..NLQQ.....RQQLIN......QQNNPANIHQQ....QFgnngPGL......Q..QQ..HLLG...HESGNAD
  420-  445 (39.72/ 7.22)	T..........SH.......................H.....................S..THML.....Q....................QP....KV....PMQ......Q..QS..........QQNTSN
  468-  509 (40.58/ 7.59)	H..........TQ.......................S.....................A..QLQQ.....Q...LG......LQQ......QP....N.....PSQ......RdmQQriQASGsllQQQNVLD
  676-  721 (44.13/ 9.10)	Q..........LQ.......................S.....................T..NLQGsvptmQQNNIA......SLQHNALA.G......V....STG......Q..QN...MMN...SMQPVTN
  726-  777 (42.94/ 8.59)	H..........GN.......................S.....................M..NSLQ.....QVPMSS......LQQNPVSTPQQtninSL....PSQgganmiQ..PN...AL.....QSGSSA
  779-  843 (44.37/ 9.20)	Q..........HQ.......................LkhqqeqqmlqsqqfkqqyqqrQ..QLMQ.....RQ.QLL......QQQQLHHPAKP....QL....SSQ......L..QT..HQMP...QLHQMND
  866-  915 (38.79/ 6.82)	S..........GQ.......................H.....................StySHQQ...lkQGSAFPvsspqlLQAASPQIQQH....SS....P.Q......V..DQ..Q..N...HLP..SK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.69|      24|      27|     131|     157|       6
---------------------------------------------------------------------------
  119-  145 (35.04/14.27)	QSQVHNLGQQHSIPLPGQLqphQQLLS
  146-  169 (40.65/11.20)	QNVQNNVASQPNLPPVSSL...AQTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.40|      15|      19|      56|      74|       7
---------------------------------------------------------------------------
   56-   74 (20.38/26.72)	LRKIAQrfedKIFTAAT.SQ
   78-   93 (21.02/13.96)	LRKISL....KMLTMETkSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.38|      14|      15|     921|     934|       8
---------------------------------------------------------------------------
  921-  934 (28.34/14.07)	PLQSSNSPFVGPTP
  937-  950 (24.03/10.60)	PLAPSPMPGESEKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.56|      15|      15|     534|     548|       9
---------------------------------------------------------------------------
  534-  548 (28.21/16.58)	QTAQPSGADWQEEVY
  552-  566 (28.35/16.70)	QTMKESYLPEMNEMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.42|      15|      15|     267|     281|      10
---------------------------------------------------------------------------
  267-  281 (23.71/ 6.89)	QPSMMQASSLSSIPQ
  283-  297 (27.57/ 9.42)	QQSTNVQQPMQSMPQ
  567-  581 (23.27/ 6.61)	QKIANKLQQHDSLPQ
  658-  672 (22.88/ 6.35)	QPQSQVTQVHSHENQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.20|      34|      71|     951|     984|      12
---------------------------------------------------------------------------
  951-  984 (60.20/33.32)	IPCVSSISNAA.NIGHQQTGGAIAPAQSLAIGTPG
 1023- 1057 (48.00/25.12)	INAVKSMSSKAlSAAVMDIGSVVSMNDRIAGSAPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23761 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKQIINLINSNRPRKGMNSVQAGQLPPTHMSSMQQPQSQVTQVHSHENQMNPQLQSTNLQGSVPTMQQNNIASLQHNALAGVSTGQQNMMNSMQPVTNLDSGHGNSMNSLQQVPMSSLQQNPVSTPQQTNINSLPSQGGANMIQPNALQSGSSALQHQLKHQQEQQMLQSQQFKQQYQQRQQLMQRQQLLQQQQLHHPAKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKAKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKPIPCVSSISNA
2) KKQLYQTQRTLPETSATSLDSTAQTAQPSGADWQEEV
3) LPEMNEMYQKIANKLQQHDSLPQQPKSDQIDKLRA
4) METKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLPGQLQPHQQLLSQNVQNNVASQPNLPPVSSLAQTPSQNIVQNSNIQNITGPNSVGTTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSQ
5) QSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQASSLSSIPQNQQSTNVQQPMQSMPQQHSQVIRHQQQQTSIVHQQQTAVTHQPSLPSQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQQFGNNGPGLQQQHLLGHESGNADMQTSHHSTHMLQQPKVPMQQQSQQNTSNLLLPHSQQPQPLGSQQQLMPQIHTQSAQLQQQLGLQQQPNPSQRDMQQRIQASGSLLQ
624
511
559
88
236
960
547
593
221
503










Molecular Recognition Features






MoRF SequenceStartStop




NANANA