<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23760

Description Mediator of RNA polymerase II transcription subunit 15a isoform B
SequenceMDSNNWRPNQGTNPTMDTSDWRAQLPIDSRQRIVNKIMETLKKHLPVSGPDGLHELRKIAQRFEDKIFTAATSQPDYLRKISLKMLTMETKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLPGQLQPHQQLLSQNVQNNVASQPNLPPVSSLAQTPSQNIVQNSNIQNITGPNSVGTTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSQQYLYQQQFKQKLQLQSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQASSLSSIPQNQQSTNVQQPMQSMPQQHSQVIRHQQQQTSIVHQQQTAVTHQPSLPSQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQQFGNNGPGLQQQHLLGHESGNADMQTSHHSTHMLQQPKVPMQQQSQQNTSNLLLPHSQQPQPLGSQQQLMPQIHTQSAQLQQQLGLQQQPNPSQRDMQQRIQASGSLLQQQNVLDQKKQLYQTQRTLPETSATSLDSTAQTAQPSGADWQEEVYRKLQTMKESYLPEMNEMYQKIANKLQQPKSDQIDKLRAYKTMLERMMALLQIPKNNILPNFKEKLGSYEKQIINLINSNRPRKGMNSVQAGQLPPTHMSSMQQPQSQVTQVHSHENQMNPQLQSTNLQGSVPTMQQNNIASLQHNALAGVSTGQQNMMNSMQPVTNLDSGHGNSMNSLQQVPMSSLQQNPVSTPQQTNINSLPSQGGANMIQPNALQSGSSALQHQLKHQQEQQMLQSQQFKQQYQQRQQLMQRQQLLQQQQLHHPAKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKAKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKPIPCVSSISNAANIGHQQTGGAIAPAQSLAIGTPGISASPLLAEFSAPDGAHGNALAATSGKSTVTEQPLERLINAVKSMSSKALSAAVMDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVSMTNCRLQARNFITQDGSNGIKRMKRYTSAIPLNVVPSAGSMNDSIKQLTASETSDLESTATSSVKKPKIEVNHALLEEIREINHQLIDTVVDISNEDVDPTAAVAAAEGAEGIIVKCSFIAVALSPSLKSQYASAQMSPIQPLRLLVPANYPNCSPILLDKFPVESSKENDDLSVKARSKFSTSLRSLSQPMSLGEIARTWDVCARRVISEHAQQSGGGSFSSKYGTWENCLTTN
Length1298
PositionTail
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.03
Grand average of hydropathy-0.753
Instability index63.69
Isoelectric point9.34
Molecular weight143054.87
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23760
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.27|      19|      19|     776|     794|       2
---------------------------------------------------------------------------
  240-  253 (26.34/ 6.36)	Q.QQQ...QNLLQPNQL....Q
  281-  300 (27.77/ 7.25)	QNQQStnvQQPMQS..MPQQHS
  776-  794 (30.17/ 8.76)	KHQQE...QQMLQSQQFKQQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     740.38|      70|      71|     306|     375|       4
---------------------------------------------------------------------------
  138-  200 (73.47/21.27)	Q......P..HQQLLSQNVQNNVASQPN.....L....PPVSS....LAQT.......P..............................SQNI..............V...Q..NSNI...QNITG.PNSVgttISQ................NSNL.....................QNM
  211-  279 (51.67/11.95)	R......Q..Q...IV......................PPQNSQQ.YLYQQ.......QFK..................QKLQ..lQ..SQM.qqqqqnllqpnqlqS...S..QQSImqtSSVMQ.PSMM.....Q................ASSL.....................SSI
  306-  375 (129.01/44.99)	Q......Q..QQTSIVHQQQTAVTHQPS.....L....PSQQQQQ.LMGHQ.......PNT..................TNMQ...H..AQML..............G...Q..QNNV...GDIQQ.PQRM...LSQ................QSNL.....................TNL
  376-  446 (79.95/24.03)	Q......Q..RQQLINQQNNPANIHQQQ.....FgnngPGLQQQH.LLGHE.......SGN..................ADMQtshH..STHM..............L...Q..QPKV...PMQQQ.........SQ................Q.NT.....................SNL
  466-  517 (57.83/14.58)	Q......I..HTQSAQLQQQLGLQQQPN..........PSQR......................................DMQ...Q.rIQAS..............GsllQ..QQNV................LDQ................KKQL.....................YQT
  518-  616 (40.91/ 7.35)	Q......RtlPETSATSLDSTAQTAQPS.....G....ADWQEEV.YRKLQtmkesylPEM..................NEMY...QkiANKL..............Q...QpkSDQI...DKLRA.YKTM...LERmmallqipknnilpnfKEKL.....................GSY
  617-  666 (55.57/13.62)	E......K..QIINLINSNRP....RKG.....M....NSVQAGQ.L...........P.P..................THM.......SSM................................QQ.PQSQ...VTQ...............vHSHE.....................NQM
  667-  742 (57.26/14.34)	N......P..QLQS........TNLQGS.....V....PTMQQNN.IASLQ.......HNAlagvstgqqnmmnsmqpvTNLD...S....................G...H..GNSM...NSLQQvPMSS...L.Q................QNPV.....................STP
  743-  799 (37.90/ 6.07)	Q..................QTNIN...S.....L....PSQGGAN.MI..Q.......P.....................N.........................................ALQS.GSSA...LQH................Q..LkhqqeqqmlqsqqfkqqyqqrQQL
  800-  846 (58.92/15.05)	M......Q..RQ.QLLQQQQ...LHHPA.....K....P.QLSSQ.LQTHQ..............................MP...Q.....L..............H...Q..MNDI...NDIKM.RQGM..................................................
  847-  884 (37.89/ 6.06)	..........GVKSGVF.........................QQH.LTSGQ.......HST....................YS...H..QQL...................K..QGSA...FPVSS.PQL..................................................L
  885-  956 (60.01/15.51)	QaaspqiQ..QHSSPQVDQQ...NHLPSkakvtT....PLQSSNSpFVGPT.......P.S..................PPLA...P..SPMP..............G...E..S.........EK.PIPC...VSS................ISNA.....................ANI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.32|       9|      24|      48|      59|       5
---------------------------------------------------------------------------
   48-   59 (12.78/13.18)	SGPDglhELRKI
   73-   81 (18.54/ 8.54)	SQPD...YLRKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.67|      15|      17|    1016|    1030|       6
---------------------------------------------------------------------------
  987- 1001 (20.04/10.38)	FSAPDGAHGNALAAT
 1016- 1030 (21.69/11.96)	INAVKSMSSKALSAA
 1034- 1048 (19.95/10.30)	IGSVVSMNDRIAGSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.88|      10|      31|     974|     983|       7
---------------------------------------------------------------------------
  974-  983 (17.84/10.24)	GTPGISASPL
 1003- 1012 (17.05/ 9.40)	GKSTVTEQPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23760 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKQIINLINSNRPRKGMNSVQAGQLPPTHMSSMQQPQSQVTQVHSHENQMNPQLQSTNLQGSVPTMQQNNIASLQHNALAGVSTGQQNMMNSMQPVTNLDSGHGNSMNSLQQVPMSSLQQNPVSTPQQTNINSLPSQGGANMIQPNALQSGSSALQHQLKHQQEQQMLQSQQFKQQYQQRQQLMQRQQLLQQQQLHHPAKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKAKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKPIPCVSSISNA
2) KKQLYQTQRTLPETSATSLDSTAQTAQPSGADWQEEV
3) METKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLPGQLQPHQQLLSQNVQNNVASQPNLPPVSSLAQTPSQNIVQNSNIQNITGPNSVGTTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSQ
4) QSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQASSLSSIPQNQQSTNVQQPMQSMPQQHSQVIRHQQQQTSIVHQQQTAVTHQPSLPSQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQQFGNNGPGLQQQHLLGHESGNADMQTSHHSTHMLQQPKVPMQQQSQQNTSNLLLPHSQQPQPLGSQQQLMPQIHTQSAQLQQQLGLQQQPNPSQRDMQQRIQASGSLLQ
617
511
88
236
953
547
221
503










Molecular Recognition Features






MoRF SequenceStartStop




NANANA