<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23759

Description Mediator of RNA polymerase II transcription subunit 15a isoform C
SequenceMDSNNWRPNQGTNPTMDTSDWRAQLPIDSRQRIVNKIMETLKKHLPVSGPDGLHELRKIAQRFEDKIFTAATSQPDYLRKISLKMLTMETKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLPGQLQPHQQLLSQNVQNNVASQPNLPPVSSLAQTPSQNIVQNSNIQNITGPNSVGTTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSQQYLYQQQFKQKLQLQSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQASSLSSIPQNQQSTNVQQPMQSMPQQHSQVIRHQQQQTSIVHQQQTAVTHQPSLPSQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQQFGNNGPGLQQQHLLGHESGNADMQTSHHSTHMLQQPKVPMQQQSQQNTSNLLLPHSQQPQPLGSQQQLMPQIHTQSAQLQQQLGLQQQPNPSQRDMQQRIQASGSLLQQQNVLDQKKQLYQTQRTLPETSATSLDSTAQTAQPSGADWQEEVYRKLQTMKESYLPEMNEMYQKIANKLQQHDSLPQQPKSDQIDKLRAYKTMLERMMALLQIPKNNILPNFKEKLGSYEKQIINLINSNRPRKGMNSVQAGQLPPTHMSSMQQPQSQVTQVHSHENQMNPQLQSTNLQGSVPTMQQNNIASLQHNALAGVSTGQQNMMNSMQPVTNLDSGHGNSMNSLQQVPMSSLQQNPVSTPQQTNINSLPSQGGANMIQPNALQSGSSALQHQLKHQQEQQMLQSQQFKQQYQQRQQLMQRQQLLQQQQLHHPAKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKAKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKPIPCVSSISNAANIGHQQTGGAIAPAQSLAIGTPGISASPLLAEFSAPDGAHGNALAATSGKSTVTEQPLERLINAVKSMSSKALSAAVMDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVSMTNCRLQARNFITQDGSNGIKRMKRYTSAIPLNVVPSAGSMNDSIKQLTASETSDLESTATSSVKKPKIELLLLLLKGQKGSLSNALSLPWLSALA
Length1166
PositionTail
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.02
Grand average of hydropathy-0.808
Instability index64.16
Isoelectric point9.73
Molecular weight128719.05
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23759
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     579.14|      71|      71|     267|     337|       3
---------------------------------------------------------------------------
  139-  200 (57.20/10.08)	.PHQ...QLLSQNVQ..NN.VA....S....Q...P...NLPPVSSLAQT..PsQNiV....QNSNIQN..I...TGPNSVGTTISQNS.N........................LQNM.
  201-  251 (54.02/ 9.03)	........FPG.SQR..QM.PG....R....Q................QIvpP.QN.S....QQYLYQQQFK...QKLQLQSQM...QQ.QQQN................L..LQPNQ..
  252-  319 (97.84/23.57)	........LQSSQQS...I.MQtssvM....Q...P...SMMQASSLSSI..P.QN.Q....QSTNVQQPMQ...SMPQQHSQVIRHQQ.QQTS................I..VHQQQTA
  320-  389 (100.39/24.41)	VTHQP..SLPSQQQQ..QL.MG....H....Q...PnttNMQHAQMLG......QQ.N....NVGDIQQP.Q...RMLSQQSNLTNLQQ.RQQL................I..NQQNNPA
  466-  517 (47.20/ 6.77)	QIHTQ..S..AQLQQ..QLgLQ....Q....Q....................P..N.P....SQRDMQQRIQasgSLLQQ..QNVLDQK.KQ.....................LYQT...
  579-  649 (60.88/11.31)	LPQQP..K..SDQID..KL.RA....Y....KtmlE...RMM...ALLQI..P.KN.N....ILPNFKEKLG...SYEKQIINLINSNR.PRKG................MnsVQAGQLP
  650-  713 (55.45/ 9.51)	PTHMS..SMQQPQSQvtQV.HS....HenqmN...P...QL.....................QSTNLQGSVP...TMQQNNIASLQHNA.LAGV................S..TGQQNMM
  714-  753 (47.75/ 6.95)	NSMQPvtNLDS..........G....H....G...N...SM......NSL..Q.Q.............VPMS...SL.............QQNP................V..STPQQTN
  818-  905 (58.41/10.49)	.LHHP..AKP.QLSS..QL.QT....H...qM...P...QLHQMNDINDI..K.MR.QgmgvKSGVFQQHLT...S..GQHST.YSHQQlKQGSafpvsspqllqaaspqI..QQHSSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.97|      28|      28|     944|     971|       4
---------------------------------------------------------------------------
  390-  418 (42.79/17.64)	NIHQQQFGNN..........gPGLQQQHLLGHESGNADM
  962- 1000 (40.19/16.13)	NIGHQQTGGAiapaqslaigtPGISASPLLAEFSAPDGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.40|      15|      21|      56|      74|       5
---------------------------------------------------------------------------
   56-   74 (20.38/28.00)	LRKIAQrfedKIFTAAT.SQ
   78-   93 (21.02/14.57)	LRKISL....KMLTMETkSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.21|      13|      23|      13|      27|       6
---------------------------------------------------------------------------
   13-   27 (21.17/21.91)	NPTMDTsdWRAQLPI
   35-   47 (23.03/15.23)	NKIMET..LKKHLPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.21|      12|      23|    1036|    1049|       7
---------------------------------------------------------------------------
 1036- 1049 (16.42/20.65)	AAVMDigSVVSMND
 1062- 1073 (20.78/15.72)	AAVGE..DLVSMTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.76|      16|      28|     912|     927|       8
---------------------------------------------------------------------------
  527-  540 (23.67/ 9.86)	TSLDST..AQTAQP....SG
  755-  774 (21.36/ 8.03)	NSLPSQggANMIQPnaLQSG
  910-  925 (28.73/13.87)	NHLPSK..AKVTTP..LQSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23759 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKQIINLINSNRPRKGMNSVQAGQLPPTHMSSMQQPQSQVTQVHSHENQMNPQLQSTNLQGSVPTMQQNNIASLQHNALAGVSTGQQNMMNSMQPVTNLDSGHGNSMNSLQQVPMSSLQQNPVSTPQQTNINSLPSQGGANMIQPNALQSGSSALQHQLKHQQEQQMLQSQQFKQQYQQRQQLMQRQQLLQQQQLHHPAKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKAKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKPIPCVSSISNA
2) KKQLYQTQRTLPETSATSLDSTAQTAQPSGADWQEEV
3) LPEMNEMYQKIANKLQQHDSLPQQPKSDQIDKLRA
4) METKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLPGQLQPHQQLLSQNVQNNVASQPNLPPVSSLAQTPSQNIVQNSNIQNITGPNSVGTTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSQ
5) QSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQASSLSSIPQNQQSTNVQQPMQSMPQQHSQVIRHQQQQTSIVHQQQTAVTHQPSLPSQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQQFGNNGPGLQQQHLLGHESGNADMQTSHHSTHMLQQPKVPMQQQSQQNTSNLLLPHSQQPQPLGSQQQLMPQIHTQSAQLQQQLGLQQQPNPSQRDMQQRIQASGSLLQ
624
511
559
88
236
960
547
593
221
503










Molecular Recognition Features






MoRF SequenceStartStop




NANANA