<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23753

Description Mediator of RNA polymerase II transcription subunit 15a isoform E
SequenceMDSNNWRPNQGTNPTMDTSDWRAQLPTDSRQRIVNKIMDTLKKHLPASGPDGLHELRKIAQRFEDKIYTAATSQPDYLRKISLKMLTMETKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNLGQQHSIPLSSQLQPHQQLVSQNVQNNVASQPNLPPVSSLAQTTSQNIVQNSNMQNITGPNSVGSTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSPQYLYQQQRLKQKQLQSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQTSSLSSIPQNQQSTNVQQSMQSMPQQHSQVIRHQQQQTSIVHQQQIPVTQQPSLPAQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQLGNNGPGLQQQHLLGHESGNADMQTSHHSAHMLQQPKVPMQQQSQQSTSNLLLPHSQQSQPLGSQQQLMPQIHTQSAQLQQQLGLPQQLNPSQRDMQQRIQASGSLLQQQNVLDQQKQLYQTQRTLPETSATSLDSTTQTAQPSGADWQEEVYQKLQTMKESYLPEMNEMYQKIANKLHQHDSLPQQPKLDQIDKLRAYKSMLERMMALLQIPKNNILPNFKEKLGSYEKQIINLLINSNRPRKGMNSVQAGHHPPTHMSSMQQPQSQVTQVHSHENQMNSQLQSTNLQGSVPTMQQNNIASMQHNSLSGVSTGQQNMMNSMQPGTNLDSVHGNSVNSLQQIPMNSLQQNPVSTAQQTNINSLPSQGGANVIQPNALQSGSSALQHQLKHQQEQQMLQSQQLKQQYQRQQLMQRQLLQQQQQLHHPGKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKTKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKSIPCVSSISNAANIGLQQTGGAVAPAQSLAIGTPGISASPLLAEFSCPDGAHGNALAATSGKSTVTEQPLERLINAVKSISRKALSAAVMDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVSMTNCRLQARNFIAQDGSNGIKRMKRYTSAIPLNVVSSPGSMNDSIKQLTASETSDLESTATSSVKKPKIEVNHALLEEIREINHRLIDTVVDISNEDVDPTAAVAAAEGAEGIIVKCSFIAVALSPSLKSQYASSQMSPIQPLHLLVPANYPNCSPILLDKFPVESR
Length1236
PositionTail
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.02
Grand average of hydropathy-0.761
Instability index63.42
Isoelectric point9.32
Molecular weight136239.24
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     876.00|      76|      76|     330|     405|       1
---------------------------------------------------------------------------
   81-  142 (72.55/17.49)	I..........SLKML..................TMETK.....SQNTLA..NN.............M.......P...PN.QVGPSN....K.PpDQ....G.................L...VL.......QSQVHNL....GQ..............Q.HSIP..L.SSQL...QP..HQ...Q
  147-  238 (69.57/16.39)	N..........VQNNV..................ASQPN.....LPPVSS.lAQ.............T..TS...QnivQNsNMQNIT....G.P.NS....V..............gstI...SQ.......NSNLQNMfpgsQR....qmpgRQQIVPP.QNSPQYL.YQQQRLKQKQLQS...Q
  242-  324 (74.03/18.03)	Q..........QQNLL....................QPN.......QLQS..SQqsimqtssvmqpsM..M....Q...TS.SLSSI.......P.Q...........................NQ.......QS..TNV....QQsmqsmpqqHSQVIRH.QQQQTSIvHQQQ...IPVTQQ...P
  330-  405 (146.62/44.60)	Q..........QQQLM..................GHQPN.....TTNMQH..AQ.............M..LG...Q...QN.NVGDIQ....Q.P.QR....M.................L...SQ.......QSNLTNL....QQ........RQQLINQ.QNNPANI.HQQLGNNGPGLQQ...Q
  411-  482 (82.39/21.09)	E..........S......................GNADM.....QTSHHS..AH.............M..L....Q...QP.KVPMQQ....Q.S.QQstsnL.................LlphSQ.......QSQ..PL....GS........QQQLMPQiHTQSAQL.QQQL.....GLPQ...Q
  483-  548 (49.63/ 9.09)	L..........N.........................PS.....QRDMQQ.rIQ.............A..SGsllQ...QQ.NVLDQQkqlyQ.T.QR....T.................L...PE.......TSA.TSL....DS........T....TQ.TAQPS..........GADWQEevyQ
  554-  621 (50.41/ 9.38)	K..........ESYL......................PE.....MNEMYQkiAN.............K..LH...Q...HD.SLP..Q....Q.P.K.......................L...DQidklrayKSMLERM....MA........LLQ.IPK.NNILPNF.KEKLGS...........
  622-  692 (65.26/14.82)	Y..........EKQIInllinsnrprkgmnsvqaGHHP......PTHM....SS.............M...................Q....Q.P......................................QSQVTQV....HS........HENQMNS.QLQSTN.....LQGSVPTMQQ...N
  698-  760 (62.29/13.73)	QhnslsgvstgQQNMM.................nSMQPG......TNLDS..VH.................G........N.SVNSLQ....QiP.........................................MNSL....QQ..................NPVST.AQQTNINS..LPS...Q
  761-  814 (66.38/15.23)	G..........GANVI....................QPNalqsgSSALQH...Q.............L..KH...Q...QE...............QQ....M.................L....Q.......SQQLKQQ....YQ........RQQLMQR.Q...............L.LQQ...Q
  815-  899 (80.31/20.32)	Q..........Q..L....................HHPG.kpqlSSQLQT..HQ.............MpqLH...Q...MN.DINDIK....M.R.QG....M.................G...VK...sgvfQQHLTSG....QH....stysHQQLKQG.SAFPVSS.PQLLQAASPQI.Q...Q
  907-  984 (56.55/11.63)	Q..........QNHLP..................SKTKV.....TTPLQS..SN.........................SP.FVGPTP....S.P.PL....ApspmpgeseksipcvssI...SN.......AANI.GL....QQ........TGGAV.....APA....QSLAIGTPGI......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.06|      12|      20|      13|      31|       2
---------------------------------------------------------------------------
   13-   26 (20.42/24.78)	NPTMDTsdWRAQLP
   35-   46 (22.64/ 6.63)	NKIMDT..LKKHLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23753 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LINSNRPRKGMNSVQAGHHPPTHMSSMQQPQSQVTQVHSHENQMNSQLQSTNLQGSVPTMQQNNIASMQHNSLSGVSTGQQNMMNSMQPGTNLDSVHGNSVNSLQQIPMNSLQQNPVSTAQQTNINSLPSQGGANVIQPNALQSGSSALQHQLKHQQEQQMLQSQQLKQQ
2) MDSNNWRPNQGTNPTMDTSDWRAQLPTDSRQRIVNKIMDTLKKHLPASGPDGLHELRKIA
3) METKSQNTLANNMPPNQVGPSNKPPDQGLVLQSQVHNL
4) PEMNEMYQKIANKLHQHDSLPQQPKLDQIDKLR
5) QKQLYQTQRTLPETSATSLDSTTQTAQPSGADWQEEV
6) QLQSQMQQQQQNLLQPNQLQSSQQSIMQTSSVMQPSMMQTSSLSSIPQNQQSTNVQQSMQSMPQQHSQVIRHQQQQTSIVHQQQIPVTQQPSLPAQQQQQLMGHQPNTTNMQHAQMLGQQNNVGDIQQPQRMLSQQSNLTNLQQRQQLINQQNNPANIHQQLGNNGPGLQQQHLLGHESGNADMQTSHHSAHMLQQPKVPMQQQSQQSTSNLLLPHSQQSQPLGSQQQLMPQIHTQSAQLQQQLGLPQQLNPSQRDMQQRIQASGSLLQ
7) QQHSIPLSSQLQPHQQLVSQNVQNNVASQPNLPPVSSLAQTTSQNIVQNSNMQNITGPNSVGSTISQNSNLQNMFPGSQRQMPGRQQIVPPQNSPQYLYQQQRLK
8) QRQLLQQQQQLHHPGKPQLSSQLQTHQMPQLHQMNDINDIKMRQGMGVKSGVFQQHLTSGQHSTYSHQQLKQGSAFPVSSPQLLQAASPQIQQHSSPQVDQQNHLPSKTKVTTPLQSSNSPFVGPTPSPPLAPSPMPGESEKSIPC
630
1
88
559
510
234
127
807
799
60
125
591
546
502
231
952










Molecular Recognition Features






MoRF SequenceStartStop




NANANA