<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23731

Description Mediator of RNA polymerase II transcription subunit 12 isoform A
SequenceMQRYHAGSCTSAVNNSAIGGPSTRDIGRTDSSSLPANFPVSSRRQPPLAPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVQNFGKTVVLSCKEAIRKRLRAINESRVRKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFRKKWIEGLSQQHKQLRSLADLVPHVRRKSLLEVLIRNNVPLLRATWFIKVSYLNLVRLGSASIPSGTADKTQLSCSELWTKDVIEYLQTLLDEFFSKNTSHFTPHNRDQSPQVPYTASLQHRSDQLLSVADGEEPSLHFRWWYIVRLLQWHHAEGLLLPSLIIDWVLRQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVHTLAGVALRIIRDPAPGGSDLVDNSRRAYTTSALIEMLRYLIFAASETFVALDCFPLPSSVVSHTINDGNFVLKATEAAGKIINSSEDVVCLFRSKGFDAQFQSLAFDHVISCIQERVEDLTKAVSPGYPGQCLAKASQALDKSLVLGDIHGAYKFLFEDLCDESVSEGWVAKVSHCLRLSLKWFVTVNKSLVYSVFFLCEWATCDFRDFRNAPPCDVKFTGRKDLSQVHIAIRLLKVKLRDMQISPKQKSGSTRGHGVSYLAKCSSLQSNQNFVNNAFKIKSSSRNLDQNICSSAIFESPGPLHDIIVCWIDQHMVHKGEGFKRLHLYIVELIRAGIFYPLAYVRQLIVSGIMDMNVNVVDLERQKRHCRILKQLPGKFVRGALVESGISEGPWLTEALRVYLNERRLILRGSLWENHDNANNVNISSLKRKHCTTSTKDRASTVSIDPWKSIFSNKISSKNAKDDNCVEELKTFISTLLQLPKSLTNLSTTGLDESQGSVRKPIGSHNKIDLVEATPGCEECRKSKRQKLSEERSSFVQAPSLVLSDDEDTWWVKKGLKSSEPLKVDQPLKSTKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHVCGNKVSCPHHRTAMDGDTTRSVDGIRSGHCEDIVSIGRALKQLRFVERKEVTLWLMTVFRELIEESEKDVGKVSQFGRPFATVDDKSSIRWKLGEDELSALLYLMDVSDDLVSAVKFLVWLLPKVYISPNSTIHSGRNVENQACDVGEAFLLSSLRRYENILTAADLLPEALSSIMHRAAAIIAASNGRVSGSGALTFARYLLKKYGNVVSVIEWEKSFKSTCDKRLASELESGRSVDGELGLPLGVPAGVEDPDDFFRQKITGGRFPSRVGSGMRDVVQRNVEEAFLDLFGKDRKLFAAGTPKGPAFEKWDNGYQIAKQIVMGLIDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPTLAKLPDFSAGSNHSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDTGTISNDAANNSSKIVVARTTKISAAVSALVVGAIICGVTSLERIVTILRLKEGLDVVQFVRSTRSNSNGNVRSVGAFKVDSSVEVHVHWFRLLVGNCRTICEGLVVDLLGEPSIVALSRMQHILPLTLVFPPAYSIFAFVIWRPFVMNANVAVREDMNQLYQSLTMAISDAIKHLPFRDVCLRECQGLYDLMAADTSDAEFATLLELNGSDMHSKSLAFVPLRARHFLNAMIDCKMPHSIYTKDEGSRNSGHGESKIDFTDSESTLRDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKLKTHDMSLADAIQLSSPSSEKGTASENENNFIEIILTRLLVRPDAAPLFSELVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIKQRLINIAETKRFSVKTQFSEPWGWCTPCKDPVAVQGDKMKVDSMPLEEGEVAEEGMDVKRSIKGFSQVVDSESSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQIALVTRGPSKPMASTPVTEGQTNKVNNRKAIRGGSPGLARRPTPAPDSSPLSPAALRASISLRVQLLMRFLPILCTDGDSSVWSVRYTLASVLLRLLGSRVVHEDVTVKAMYYTPLRREAESHAEAAFVDSSVEGLFDHLLLILHGLLSSSPPSWLRSKSVSKTTNEPTREFSGFEREPLEALQNHLDNMQLPDTIRWRIQAAMPVLPPSIRCSFSCQLPTVPASALASLQPSTTNSGFNSSCSTVPQRNLVSSSRTTASGRSKLQDNDSDVDPWTLLEDGAGSCSSASNTAIIGSGDRVNIRAASWLKGAVRVRRTDLSYVGAVDEDS
Length2259
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.202
Instability index48.48
Isoelectric point8.57
Molecular weight250236.13
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23731
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.76|      44|     942|     764|     810|       1
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  764-  810 (73.09/60.10)	WLTEALRVYLNERRLILRgslWENHDN..ANNVNISSLKRKHCTTSTKD
 1709- 1754 (70.67/49.45)	WQWVELRLLLNEQALIEK...LKTHDMslADAIQLSSPSSEKGTASENE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.16|      39|     942|      85|     127|       2
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   85-  127 (56.04/38.69)	YLQSGYRDTVeglEESrEISLTQVQNFGKT.VVLSCKEAIRKRL
 1034- 1073 (64.12/33.25)	WLMTVFRELI...EES.EKDVGKVSQFGRPfATVDDKSSIRWKL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     233.03|      96|     529|    1408|    1532|       3
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  464-  519 (29.55/10.39)	SKGFDAQFQSLAFDHVISCIQE............RVEDLTKAVSpgypgqclakasqaldkSLVLGDI.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1134- 1203 (60.09/30.36)	....................................................................hgaykflfedlcdesvsegwvakvshclrlslkwfvtvnkslvysvfflcewatcdfrdfrnappcdvkftgrkdlsqvhiairllkvklrdmqispkqksgstrghgvsylakcsslqsnqnfvnnafkiksssrnldqnicssaifespgplhdiivcwidqhmvhkgegfkrlhlyiveliragifyplayvrqlivsgimdmnvnvvdlerqkrhcrilkqlpgkfvrgalvesgisegpwltealrvylnerrlilrgslwenhdnannvnisslkrkhcttstkdrastvsidpwksifsnkissknakddncveelktfistllqlpksltnlsttgldesqgsvrkpigshnkidlveatpgceecrkskrqklseerssfvqapslvlsddedtwwvkkglksseplkvdqplkstkqvtktrqktvrktqslaqlaasriegsqgastshvcgnkvscphhrtamdgdttrsvdgirsghcedivsigralkqlrfverkevtlwlmtvfrelieesekdvgkvsqfgrpfatvddkssirwklgedelsallylmdvsddlvsavkflvwllpkvyispnstihsgrnvenqacdvgeafllsSLRRYENILTaadlLPEALsSIMHRAAAIIAASNGRVSGSGALtfaryllkKYGNVVSV.IEWEKSFKSTC
 1409- 1522 (143.39/178.92)	SKASRAQFQMSPETHDTGTISNdaannsskivvaRTTKISAAVS.................ALVVGAI.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................icgvtSLERIVTILR....LKEGL.DVVQFVRSTRSNSNGNVRSVGAF........KVDSSVEVhVHWFRLLVGNC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.58|      79|     529|    1581|    1688|       4
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 1581- 1688 (114.54/113.79)	DMNQLYQSLTMAISDAIKHLPFRDVCLRECQglydLMAADTSdaEFATLLELNGSDMHSKSLAFVPLRarhflnamidckmphsiytkdegSRNSGHGESKIDFTDSE
 2118- 2201 (136.04/76.55)	DNMQLPDTIRWRIQAAMPVLPPSIRCSFSCQ....LPTVPAS..ALASLQPSTTNSGFNSSCSTVPQR..................nlvssSRTTASGRSKLQDNDSD
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.51|      58|     522|     703|     763|       6
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  703-  763 (91.69/81.00)	IRAGIFYPLAYVRQLIVSGIMDMNV..NVVDLeRQKRHCRILKQLPGKFVRgaLVESGISEGP
 1227- 1286 (97.82/73.88)	VPAGVEDPDDFFRQKITGGRFPSRVgsGMRDV.VQRNVEEAFLDLFGKDRK..LFAAGTPKGP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23731 with Med12 domain of Kingdom Viridiplantae
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