<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23729

Description Mediator of RNA polymerase II transcription subunit 12 isoform C
SequenceMQRYHAGSCTSAVNNSAIGGPSTRDIGRTDSSSLPANFPVSSRRQPPLAPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVQNFGKTVVLSCKEAIRKRLRAINESRVRKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFRKKWIEGLSQQHKQLRSLADLVPHVRRKSLLEVLIRNNVPLLRATWFIKVSYLNLVRLGSASIPSGTADKTQLSCSELWTKDVIEYLQTLLDEFFSKNTSHFTPHNRDQSPQVPYTASLQHRSDQLLSVADGEEPSLHFRWWYIVRLLQWHHAEGLLLPSLIIDWVLRQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVHTLAGVALRIIRDPAPGGSDLVDNSRRAYTTSALIEMLRYLIFAASETFVALDCFPLPSSVVSHTINDGNFVLKATEAAGKIINSSEDVVCLFRSKGFDAQFQSLAFDHVISCIQERVEDLTKAVSPGYPGQCLAKASQALDKSLVLGDIHGAYKFLFEDLCDESVSEGWVAKVSHCLRLSLKWFVTVNKSLVYSVFFLCEWATCDFRDFRNAPPCDVKFTGRKDLSQVHIAIRLLKVKLRDMQISPKQKSGSTRGHGVSYLAKCSSLQSNQNFVNNAFKIKSSSRNLDQNICSSAIFESPGPLHDIIVCWIDQHMVHKGEGFKRLHLYIVELIRAGIFYPLAYVRQLIVSGIMDMNVNVVDLERQKRHCRILKQLPGKFVRGALVESGISEGPWLTEALRVYLNERRLILRGSLWENHDNANNVNISSLKRKHCTTSTKDRASTVSIDPWKSIFSNKISSKNAKDDNCVEELKTFISTLLQLPKSLTNLSTTGLDESQGSVRKPIGSHNKIDLVEATPGCEECRKSKRQKLSEERSSFVQAPSLVLSDDEDTWWVKKGLKSSEPLKVDQPLKSTKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHVCGNKVSCPHHRTAMDGDTTRSVDGIRSGHCEDIVSIGRALKQLRFVERKEVTLWLMTVFRELIEESEKDVGKVSQFGRPFATVDDKSSIRWKLGEDELSALLYLMDVSDDLVSAVKFLVWLLPKVYISPNSTIHSGRNVENQACDVGEAFLLSSLRRYENILTAADLLPEALSSIMHRAAAIIAASNGRVSGSGALTFARYLLKKYGNVVSVIEWEKSFKSTCDKRLASELESGRSVDGELGLPLGVPAGVEDPDDFFRQKITGGRFPSRVGSGMRDVVQRNVEEAFLDLFGKDRKLFAAGTPKGPAFEKWDNGYQIAKQIVMGLIDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPTLAKLPDFSAGSNHSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDTGTISNDAANNSSKIVVARTTKISAAVSALVVGAIICGVTSLERIVTILRLKEGLDVVQFVRSTRSNSNGNVRSVGAFKVDSSVEVHVHWFRLLVGNCRTICEGLVVDLLGEPSIVALSRMQHILPLTLVFPPAYSIFAFVIWRPFVMNANVAVREDMNQLYQSLTMAISDAIKHLPFRDVCLRECQGLYDLMAADTSDAEFATLLELNGSDMHSKSLAFVPLRARHFLNAMIDCKMPHSIYTKDEGSRNSGHGESKIDFTDSESTLRDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKLKTHDMSLADAIQLSSPSSEKGTASENENNFIEIILTRLLVRPDAAPLFSELVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIKQRLINIAETKRFSVKTQFSEPWGWCTPCKDPVAVQGDKMKVDSMPLEEGEVAEEGMDVKRSIKGFSQVVDSESSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQIALVTRGPSKPMASTPVTEGQTNKVNNRKAIRGGSPGLARRPTPAPDSSPLSPAALRASISLRVQLLMRFLPILCTDG
Length2008
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.197
Instability index47.45
Isoelectric point8.69
Molecular weight222959.92
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23729
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.74|      47|     942|     764|     810|       1
---------------------------------------------------------------------------
  715-  739 (20.32/ 8.21)	............RQLIVSGIM....D....MNVNVVDLERqkRHC......
  764-  810 (84.96/61.45)	WLTEALRVYLNERRLILRGSLWENHDN..ANNVNISSLKR..KHCTTSTKD
 1709- 1754 (67.46/47.03)	WQWVELRLLLNEQALIEK...LKTHDMslADAIQLSSPSS..EKGTASENE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.16|      39|     942|      85|     127|       2
---------------------------------------------------------------------------
   85-  127 (56.04/54.70)	YLQSGYRDTVeglEESrEISLTQVQNFGKT.VVLSCKEAIRKRL
 1034- 1073 (64.12/47.10)	WLMTVFRELI...EES.EKDVGKVSQFGRPfATVDDKSSIRWKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.75|      22|     193|     189|     240|       4
---------------------------------------------------------------------------
  189-  217 (30.16/59.09)	DLVpHVRRKSLlevlirNNVPLLRATWFI
 1777- 1798 (40.59/11.90)	ELV.HLFGKSL......EDSMLLQAKWFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.40|      30|     610|     477|     536|       5
---------------------------------------------------------------------------
  497-  532 (43.00/65.88)	GYpgqcLAKASQALDKSL...VLGDIHGAYKFLFedLCD
  538-  570 (49.41/13.87)	GW....VAKVSHCLRLSLkwfVTVNKSLVYSVFF..LCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.00|      65|      68|    1278|    1345|      11
---------------------------------------------------------------------------
 1236- 1274 (22.01/ 7.50)	...........................DF...FRQkiTGGRF......PSRVGSGMRDVVQrNVEEAFLDLfgKD.
 1280- 1345 (107.65/83.57)	AGTPKGpAFEKWDNGYQIAKQIVMGLIDC...IRQ..TGGAAQEG..DPSLVTSAVSAIVG.SVGPTLAKL..PDF
 1347- 1416 (90.35/57.89)	AGSNHS.NMSLATSSLNYAKCILRMHITClclLKE..ALGERQSRvfEIALAMEASTALAG.VFAPSKASR..AQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.70|      29|     852|     625|     653|      13
---------------------------------------------------------------------------
  625-  653 (51.04/37.11)	GHGVSYLAKCSSLQSNQNFVN.NAFKIKSS
 1478- 1507 (44.66/31.37)	GLDVVQFVRSTRSNSNGNVRSvGAFKVDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.29|      35|    1590|     374|     410|      15
---------------------------------------------------------------------------
  374-  410 (55.91/40.89)	GVALRiiRDPAPGGSDLVDNSRRAYTTSALIEMLRYL
 1967- 2001 (60.38/38.12)	GLARR..PTPAPDSSPLSPAALRASISLRVQLLMRFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23729 with Med12 domain of Kingdom Viridiplantae
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