<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23676

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGSLHQISWFQFLPHEPDLNPLPDKSVKVDQKDAAMLLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRHSSVVETAQTAVSGLRVVASGLWLAPGDSEEVAAALSQALRNCVERALFGLYYMRFGDVFSKFHQFQREELFRRGQPAVEFVFAATEEAIFIHVIVSSKHIRMLSTADLEKVLQHSMEFTYRLPVIVSPHGICGSLTGCSPSDLVKQSYFSSTKFRVSNGIIGLPYHVSQGVGCQLRGQNCYVEVSLGFPRSGTDNTLQPNKNSVRNLPKLHVAESPIVGRSDHKGSPDHLLDYDKTFLYPAEAVLVPVLQTSLARSSLRRFWLQNWMGPSLPGSSSFIHCAGNVDCTEDPWTEINGTRTQNSYDSSSNSNSSSISSLSASSSDSDYKTTRPSELEADADSLTCRQSMVSSADQLDSDGPKLGSKRSRTGVTESLSTATNIPVQDAYMSDFGSMEVNNSAITGVGNDPIGSYWDWDDDDRGMEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMLSAPDCGDVNSSPGGVIDVPGQILLPVGFPSFESFNPPPSTSIEECLNKSQDNLNNSMSLCPTNQTQLLYTREFDHIMKAEAMMTFAPEFGAVDTPTSPPTSPCTEGSEGKNGMSANTKTGSGKYDASTTSLHSKYYYTFVESRKEKNDKNPATCNDNSITKSEGIPPLSNIGSNAIVKSAIRKTTEGTHEAEHFLLSAKTLLATDITCVTLQASMCRLRHILLSSGNLMPVGLSRSTGVSFLNQLPSDPSMTTDNISGKYDVKKKENIPIRIAGDIDGGMLDGHLNAPVGVWRTLGASKVVKPSNSPNMEVVPSFPHNSFNEEGILSYGLRKPLQELLDGIALLVQQAISFVDLALDADCGDGPYGLLAMQEQWRRGFCCGPSMVHAGCGGSLASSHSLDIAGLELVDPLSADVDASTVISLLQSDIKTALKSAFSNLEGPLSVTDWCKGRNQLVDTGSIVDGVSAESSINECRDSSEPMSPSQSSVGGSSSIKVSNLMDKVDETSQRRSGQDLCSTELEQLSCSRLKPTLIALPFPSILVGYQDDWLKTSANSLQHWEKAPLEPYALQKPITYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQMEIESAKLSSCGFVLLDCPQSIKIESSNASLVGSVSDYFLSLSNGWDLTSYLKSLSKALRGLKIGSCFSTNPGEGSNSSCLVIYVVCPFPDPTAILQTVIESSVAIGSVAQQSDRERRSSLHSQVVKALSGLTTVDEASASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVILKETAFTVYSKARRISRGISSDFAQSAFPRSHSVLTQMPSLISGMWKDCVGPRMAGHSLPREGDIDASLRPGTWDNSWQPTRTGGLSCDPSRTGDNFLYDEIRYMFEPLFILAEPGSLENGISVIGSPTSESSKALADDSSGNYAQSTSTAGNAESASSTDGSGSDPETPPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFVQILQQGCLILQSCDPGLAKPRDFVIARIGGFYELEYLEWQKAIYSVGVSEMKRWPLQLRKSMSDGMSATSNGSSLQQSDMSLIPERTLPSSPSPLYSPHTKSTSFMKGSLGQPTARKQLMGGHSMVDNSRGLLHWAQSISFVAVSMDHTLQLVLPADSSTPGYIEGFTPVKSLGSTSSAYILIPSPSMRFLPPTVLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNQKEEWPSILSVSLIDYYGGTNIPQEKIVRGINKQGGRSLSWEAKDFEIETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1917
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.214
Instability index53.61
Isoelectric point5.29
Molecular weight208133.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23676
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1159.78|     383|     423|     974|    1396|       1
---------------------------------------------------------------------------
  974- 1396 (578.07/417.25)	SL.LQSDIKTALKsafsnlEGPLSvTDWckgrnQLVDTGSI.VDGVSAESSI..NECRDSSEPM....SPSQ....SSVGGSSSIKVSNLMdkVDETSQRRSGQDLCSTELEQLSCSRLKPTLIALPfPSI..LVGYQDDW...LKTSANSLQHWEKAPLEPYAlqkPITYHvvcPDIDPLTSAAADFFQQLGTVYETCklgthSPqGLGNQMEIESAKLSscGFVLLDCPQSIK.IESSNASLVGSVS.DYFLSLSNGWDLTSYLKSLSKALRGLKIGSCFSTNPGE.GSNSSCLVIYVVCPFPDPTAILQ.....TVIESSVAIGSVAQqsdrerrsSLHSQVVKALSGLTTVDEASASNILVLSGFS.IPKL....VLQIVTVDAIFRVTSPSVSEL..VILKET...AFTVYSKARRISrgISSDFAQS.AFP......RSHSvLTQMPSLISGMWKDCVG
 1403- 1827 (581.71/335.84)	SLpREGDIDASLR......PGTWD.NSW.....QPTRTGGLsCDPSRTGDNFlyDEIRYMFEPLfilaEPGSlengISVIGSPTSESSKAL..ADDSSGNYAQSTSTAGNAESASSTDGSGSDPETP.PSLhcCYGWTEDWrwlVCIWTDSRGELLDCNIFPFG...GISSR...QDTKGLQCLFVQILQQGCLILQSC.....DP.GLAKPRDFVIARIG..GFYELEYLEWQKaIYSVGVSEMKRWPlQLRKSMSDGMSATSNGSSLQQSDMSLIPERTLPSSPSPlYSPHTKSTSFMKGSLGQPTARKQlmgghSMVDNSRGLLHWAQ........SISFVAVSMDHTLQLVLPADSSTPGYIEGFTpVKSLgstsSAYILIPSPSMRFLPPTVLQLptCLTAESpplAHLLHSKGSALP..LSTGFVVSkAVPsmrkdyRSNQ.KEEWPSILSVSLIDYYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.76|      28|      55|     582|     611|       2
---------------------------------------------------------------------------
  582-  611 (47.51/30.08)	PSFESFNPPPSTSIEECLNKSQDnlNNSMS
  640-  667 (53.25/28.36)	PEFGAVDTPTSPPTSPCTEGSEG..KNGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.01|      21|      28|     517|     544|       3
---------------------------------------------------------------------------
  517-  540 (33.43/20.62)	DIQALLSEFGDFGDFFENdvlPFG
  547-  567 (39.57/25.47)	ESQALMLSAPDCGDVNSS...PGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.27|      10|      28|     746|     755|       4
---------------------------------------------------------------------------
  746-  755 (17.11/ 9.20)	HFLLSAKTLL
  773-  782 (18.16/10.25)	HILLSSGNLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.41|      26|      28|      59|      86|       5
---------------------------------------------------------------------------
   59-   86 (49.58/31.40)	LSTWTNSFVGPWDPS.QGLHNPDEkiKLW
   89-  115 (35.83/16.72)	LPGRHSSVVETAQTAvSGLRVVAS..GLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.21|      21|      56|     783|     804|       6
---------------------------------------------------------------------------
  783-  804 (35.59/31.33)	PVGLSRSTGVSFLNQlPSD.PSM
  841-  862 (36.62/26.45)	PVGVWRTLGASKVVK.PSNsPNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.60|      15|      27|     472|     487|       8
---------------------------------------------------------------------------
  472-  487 (25.22/19.60)	NIPVQ...DAYMSDFGsME
  498-  515 (26.38/15.26)	NDPIGsywDWDDDDRG.ME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.74|      21|      30|     397|     418|       9
---------------------------------------------------------------------------
  397-  418 (30.42/17.56)	DSSSNSNSSSISSlSASSSDSD
  430-  450 (37.32/18.23)	DADSLTCRQSMVS.SADQLDSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23676 with Med13 domain of Kingdom Viridiplantae
Unable to open file!