<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23631

Description Mediator of RNA polymerase II transcription subunit 12 isoform B (Fragment)
SequenceVLVIAVQVCVEYSLDLTLKLRFLDDSSGQNSTTLPHTSGVHKLWVSCFWYAGYNWRKCKGIMLAAALVQLITVQLVGHPLGTLEELIHLLCQLTFLRQPPLTPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVQNFSKKVVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFRKKWIEGLSQPHKRLRSLTDLVPHVRRKSLSEVLIRNNVPLLRATWFIKVSYLNVVRPGSASIPSGTADKTQLSCSELWTKDVIEYLQTLLDEFFSKNSSHFTPHNRDRSPQVPYTASFQHRSDQLLSVADGEEPSLHFRWWYIVRLLQWHHAEGLLLPSLIIDWVLRQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVRTLAGVALRIIRDPAPGGSDLVDNSRRAYTTSALIEMLRYLIFAAPETFVALDCFPLPSSVVSHTINDGNFVLKATEAAGKIKSSSEDVVCLFRSKGFDAQFQSLAFDHVISCIQECVEDLTKAVSPGYPGQCLAKAAQALDKSLVLGDIHGAYKFLFEDHCDETVSEGWVAKVSHCLRLSLKWFVTVNKSLVYSVFFLCEWATCDFRDFRNAPPCDVKFTGRKDLSHVHIAIRLLKMKLRDMQISPKHKSGSTRGCGVSYLAKCSSQQRNQNFVNNAFKIKSSSRNLDQNICSSAVFESPGPLHDIIVCWIDQHMVHKGEGLKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDMNVNVVDLERQKRHCRILKQLPGKFVRRALVESGISEGPRLTEALQVYLNERRFILRGSLWENHGNANNVNISSLKQNHCTSSTKDKTSTVSIDPWKSVFSNKTSSKNAKDDNGVEELKTFISTLLQLPKSLSNLSTTGLDESQGSVRKPIGSHNKSDLVEATPGCEECRKAKRQKLSEERSSFVQAPSPILSDDEDTWWVKKGLKSSEHLKVDQPLKPTKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHVCGNKVSCPHHRTAMDGDTTRSVDGIRSGHCEDIVSIGRALKQLRFVERKEVTLWLMTVVRQLIEESEKNVGKVSQFGRPFATVDDKSSIRWKLGEDELSALLYLMDVSDDLVSAVKFLLWLLPKVYSSPNSTIHSGRNALMLPRNVENQACDVGEAFLLSSLRRYENILAAADLLPEALSSIMHRAAAIIASNGRVSGSGALTFACYLLKKYGNVVSVIEWEKSFKSTCDKRLASEIESGRSVDGELGLPLGVPAGVEDPDDFFRQKISGGRLPSRVGSGMRDVVQRNVEEAFRDLFGKDRKLFAAGTPKGPAFEKWDNGYQIAQQIVMSLIDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPTLAKLPDFSAGSNHSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDTGTISNDVAANNTSKIVVARTTKISAAVSALVVGAIICGVTSLERIVTILRLKEGLDVVHFVRSTRSNSNGNVRSVGAFKLDSSVEVHVHWFRLLVGNCRTICEGLVVDLLGEPSIVALSRMQRMLPLTLVFPPAYSIFAFVMWRPFVMNANVAVREDMNQLYQSLTIAISDAIKHWPFRDVCLRECQGLYDLMAADTSDAEFATLLELNGSDMHSKSLAFVPLRARHILNAMIDCKMPQSIYTKDEGSRNYGHGESKIDFTDSESTLQDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKLKTHDMSLADAIQLSSPSSEKGAASENENNFIEIILTRLLVRPDAAPLFSELVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIKQRLINIAETKRFSVKTQFSEPWGWCSPCKNPVALKGDKMKVDPMPLEEGEVAEEGMDVKRSIKGFSQVFDSESSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQITLVTRGPSKPTASTPVTEGQTNKVNSRKTIRGGSPGLARRPTPAPDSSPLSPAALRASISLRVQLLMRFLPILCSDGESSARSMRYMLASVLLRLLGSRVVHEDATVNPMHYTPLRREAESHAEASFVDSSAEGLFDHLLLILHGLLSSSPPSWLRSKPVSKTTNEPTREFSGFEREPLEALQNHLDNMQLPDTIRRRIQAAMPLLPPSMRCSFSCQLPTVPASALVSLQPNTTNSGFNSGSSTVPQRNLVPSSRTTTSGKSKQHDNDLDVDPWTLLEDGAGSCPSASNTDIIGSGDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDS
Length2319
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.206
Instability index48.90
Isoelectric point8.68
Molecular weight257522.09
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23631
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     543.58|     193|     324|      69|     274|       1
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   69-  151 (75.31/56.51)	..................................................................................................................................................................QLITVQLVGHPL..GTLEelIHLLCQlTFLRQPPLTPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLtrEYLQSGYRDTVEGLE
  152-  274 (144.12/109.95)	ESREISLT.QVQNFskkvVLNCKEAIRKrLRAINESRVQKRKAgqvYGVALSGSQLAKPGVFPEQRPCPEDFRKKWIEG.....LSQPHKRL.RSLT..DLVPHVRR.KSLSEVLIR...NNVPLLRATWFIKVSY...............................................................................................................
  295-  475 (200.03/127.91)	..................................................LSCSELWTKDVIEYLQTLLDEFFSKNSSH.....FT.PHNRD.RS....PQVPYTASfQHRSDQLLSvadGEEPSLHFRWWYIVRLlqwhhaeglllpsliidwvlrqlqekQLLEIWQLLLPIvyGFLE..IVVLSQ.TYVRTLAGVALRIIRDPAPGGSDLVDNSRRAYTTSALIEML..RYLIFAAPETFVALD
  480-  598 (124.11/75.86)	PSSVVSHTiNDGNF....VLKATEAAGK.IKSSSEDVVCLFRS...KGFDAQFQSLAFDHVISCIQECVEDLTKAVSPGypgqcLAKAAQALdKSLVlgDI..HGAY.KFLFEDHCD...ETV...SEGWVAKVSH...............................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.84|      15|      16|     686|     700|       4
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  686-  700 (27.74/16.90)	KCSSQQRNQNFVNNA
  704-  718 (26.10/15.46)	KSSSRNLDQNICSSA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.51|      32|     324|     736|     771|       5
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  736-  771 (48.33/49.07)	QHMVHKGEGLKRLHLfiVEliRAGI.FYPLAYVRQLI
 1064- 1096 (50.18/35.85)	EDIVSIGRALKQLRF..VE..RKEVtLWLMTVVRQLI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.75|      20|     528|     795|     816|       6
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  795-  816 (30.39/24.13)	LKQLPGKfvRRALVESGISEGP
 1326- 1345 (37.36/22.74)	FRDLFGK..DRKLFAAGTPKGP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.36|      53|     616|    1259|    1311|       7
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 1259- 1311 (90.25/56.93)	KSTCDKRLASEIESGR.SVDGELGLPLGVPAGVEDPDDFFRQKISGGRLPSRVG
 1867- 1920 (91.11/57.55)	RKTIKQRLINIAETKRfSVKTQFSEPWGWCSPCKNPVALKGDKMKVDPMPLEEG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.25|      38|     194|    1801|    1838|      10
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 1801- 1838 (62.52/40.04)	SSPSSEKGAASENENNFIEIILTRLLVRPDAAPLFSEL
 2004- 2041 (66.73/43.30)	STPVTEGQTNKVNSRKTIRGGSPGLARRPTPAPDSSPL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.80|      38|     326|    1194|    1235|      12
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 1194- 1235 (57.37/47.57)	SLRRYENILAaadlLPEALSSIMHRAAAIIASNGRVSGSGAL
 1525- 1562 (63.43/42.70)	SLERIVTILR....LKEGLDVVHFVRSTRSNSNGNVRSVGAF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23631 with Med12 domain of Kingdom Viridiplantae
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