<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23630

Description Mediator of RNA polymerase II transcription subunit 12 isoform A
SequenceMQRYHAGSCTSAVNNSAIGGPSTRDIGRTDSSSLPANFPVSSRRQPPLTPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVQNFSKKVVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFRKKWIEGLSQPHKRLRSLTDLVPHVRRKSLSEVLIRNNVPLLRATWFIKVSYLNVVRPGSASIPSGTADKTQLSCSELWTKDVIEYLQTLLDEFFSKNSSHFTPHNRDRSPQVPYTASFQHRSDQLLSVADGEEPSLHFRWWYIVRLLQWHHAEGLLLPSLIIDWVLRQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVRTLAGVALRIIRDPAPGGSDLVDNSRRAYTTSALIEMLRYLIFAAPETFVALDCFPLPSSVVSHTINDGNFVLKATEAAGKIKSSSEDVVCLFRSKGFDAQFQSLAFDHVISCIQECVEDLTKAVSPGYPGQCLAKAAQALDKSLVLGDIHGAYKFLFEDHCDETVSEGWVAKVSHCLRLSLKWFVTVNKSLVYSVFFLCEWATCDFRDFRNAPPCDVKFTGRKDLSHVHIAIRLLKMKLRDMQISPKHKSGSTRGCGVSYLAKCSSQQRNQNFVNNAFKIKSSSRNLDQNICSSAVFESPGPLHDIIVCWIDQHMVHKGEGLKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDMNVNVVDLERQKRHCRILKQLPGKFVRRALVESGISEGPRLTEALQVYLNERRFILRGSLWENHGNANNVNISSLKQNHCTSSTKDKTSTVSIDPWKSVFSNKTSSKNAKDDNGVEELKTFISTLLQLPKSLSNLSTTGLDESQGSVRKPIGSHNKSDLVEATPGCEECRKAKRQKLSEERSSFVQAPSPILSDDEDTWWVKKGLKSSEHLKVDQPLKPTKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHVCGNKVSCPHHRTAMDGDTTRSVDGIRSGHCEDIVSIGRALKQLRFVERKEVTLWLMTVVRQLIEESEKNVGKVSQFGRPFATVDDKSSIRWKLGEDELSALLYLMDVSDDLVSAVKFLLWLLPKVYSSPNSTIHSGRNALMLPRNVENQACDVGEAFLLSSLRRYENILAAADLLPEALSSIMHRAAAIIASNGRVSGSGALTFACYLLKKYGNVVSVIEWEKSFKSTCDKRLASEIESGRSVDGELGLPLGVPAGVEDPDDFFRQKISGGRLPSRVGSGMRDVVQRNVEEAFRDLFGKDRKLFAAGTPKGPAFEKWDNGYQIAQQIVMSLIDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPTLAKLPDFSAGSNHSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDTGTISNDVAANNTSKIVVARTTKISAAVSALVVGAIICGVTSLERIVTILRLKEGLDVVHFVRSTRSNSNGNVRSVGAFKLDSSVEVHVHWFRLLVGNCRTICEGLVVDLLGEPSIVALSRMQRMLPLTLVFPPAYSIFAFVMWRPFVMNANVAVREDMNQLYQSLTIAISDAIKHWPFRDVCLRECQGLYDLMAADTSDAEFATLLELNGSDMHSKSLAFVPLRARHILNAMIDCKMPQSIYTKDEGSRNYGHGESKIDFTDSESTLQDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKLKTHDMSLADAIQLSSPSSEKGAASENENNFIEIILTRLLVRPDAAPLFSELVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIKQRLINIAETKRFSVKTQFSEPWGWCSPCKNPVALKGDKMKVDPMPLEEGEVAEEGMDVKRSIKGFSQVFDSESSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQITLVTRGPSKPTASTPVTEGQTNKVNSRKTIRGGSPGLARRPTPAPDSSPLSPAALRASISLRVQLLMRFLPILCSDGESSARSMRYMLASVLLRLLGSRVVHEDATVNPMHYTPLRREAESHAEASFVDSSAEGLFDHLLLILHGLLSSSPPSWLRSKPVSKTTNEPTREFSGFEREPLEALQNHLDNMQLPDTIRRRIQAAMPLLPPSMRCSFSCQLPTVPASALVSLQPNTTNSGFNSGSSTVPQRNLVPSSRTTTSGKSKQHDNDLDVDPWTLLEDGAGSCPSASNTDIIGSGDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDS
Length2266
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.246
Instability index50.57
Isoelectric point8.76
Molecular weight251233.31
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP23630
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      32|     197|     439|     482|       1
---------------------------------------------------------------------------
  439-  482 (46.71/50.24)	NFVlkatEAAGKIKSSSEDV...VC...LFRSKGfdaqfqslAFDHVISC
  642-  679 (51.35/29.17)	NFV....NNAFKIKSSSRNLdqnICssaVFESPG........PLHDIIVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.72|      38|     195|    1748|    1785|       3
---------------------------------------------------------------------------
 1748- 1785 (61.82/43.27)	SSPSSEKGAASENENNFIEIILTRLLVRPDAAPLFSEL
 1951- 1988 (66.90/47.57)	STPVTEGQTNKVNSRKTIRGGSPGLARRPTPAPDSSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.14|      21|     366|       3|      28|       6
---------------------------------------------------------------------------
    6-   26 (38.90/37.76)	AGSCTSAVNNSAIGGPSTRDI
 2219- 2239 (39.24/18.21)	AGSCPSASNTDIIGSGDRVNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.20|      52|     616|    1206|    1258|       8
---------------------------------------------------------------------------
  984- 1012 (30.34/ 9.85)	KVSCpHHRTAMDGDTTR.SVD.......GIRSGhCED..................
 1206- 1257 (88.57/49.66)	KSTC.DKRLASEIESGR.SVDGELGLPLGVPAG.VEDPDDFFRQKISGGRLPSRV
 1816- 1866 (79.30/46.06)	..TI.KQRLINIAETKRfSVKTQFSEPWGWCSP.CKNPVALKGDKMKVDPMPLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.09|      18|     616|     287|     311|       9
---------------------------------------------------------------------------
  287-  311 (26.52/30.58)	SFQHRSDQLLSvaDGEEPslhfrWW
  907-  924 (36.57/20.19)	SFVQAPSPILS..DDEDT.....WW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.75|      20|     528|     742|     763|      10
---------------------------------------------------------------------------
  742-  763 (30.39/26.37)	LKQLPGKfvRRALVESGISEGP
 1273- 1292 (37.36/24.85)	FRDLFGK..DRKLFAAGTPKGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23630 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALVSLQPNTTNSGFNSGSSTVPQRNLVPSSRTTTSGKSKQHDNDLDVDPWTL
2) HLKVDQPLKPTKQVTKTRQKTVRKTQSLAQLAASRI
3) QPPLTPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLTREY
4) SCTSAVNNSAIGGPSTRDIGRTDSSSLPANFPVSSR
5) STTGLDESQGSVRKPIGSHNKSDLVEATPG
6) TRGPSKPTASTPVTEGQTNKVNSRKTIRGGSPGLARRPTPAPDSSPLS
2163
934
45
8
860
1942
2214
969
85
43
889
1989










Molecular Recognition Features






MoRF SequenceStartStop




1) RKKWI
170
174