<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23620

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGSMHQISWFQFLPHEPDLNPLPDKSVKVDQKDAAMLLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLRGRHSSVVETAQTAVSGLRVVASGLWLAPGDSEEVAAALSQALRNCIERALLGLYYMRFGDVFSKFHQFQREEIFRRGQPAVEFVFAATEEAIFIHVIVSSKHIRMLSTADLEKVLKHSMESTYRLPVIVSPHGIRGSLTGCSPSDLVKQSYFSSTKFRVSNGIIGLPYHVSQGVGCQLRGQNCYVEVSLGFPRSGTDNTLQPNKNSVRNLPKLHVAESPVVGRSDHKGPPDHLLDYDKTFLYPAEAVLVPVLQTSLARSSLRRFWLQNWMGPSLPGSSSFIHCAGNVDCTEDPWTEINGTRTQSSYDSSSNSNNSSISSLSASSSDSDYKTTGPSELEADADSLTCRQSMVSSADQLDSDGPKLGSKRSRTGVTELLSTATNIPVQDAYMSDFGSMEVNNSAITGVGNEPIGSYWDWDDDDRGMEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMLSAPDCGDVNSSPGGVIDVPDQILLPVGFASFESFNPPPSTSIEECLNKSQDNLNNSMSLGPTNQNQLLYTREFDHIMKAEAMMTFAPEFGAVDTPTCEFSTTLFRSPYFPKSRKAKSSTSSSSNYLYGAAPPTSTCTEGSEGKNGKSVNTKTGSGKHDASTMSLHSKYYYTFVESRKEKNDKNPATCNDNSITKSEGMPPLSNIGSNAIVKSAIRKTTDCTHEAEQFLLSAKTLLATDITCIMLQASMCRLRHILLSSGNLMPAGLSRSTGVSFLNQLPSDPSMTTDNISGKYDVKKKENIPIRIAGDIDGGMLDGHLNAPVGVWRTLGASKVVKPSNSPNMEVVPSFPHNSFNEEGILSYGQRKPLQELLDGIALLVQQAISFVDLALDVDCGDGPYGLLAMQEQWRRGFCCGPSMVHAGCGGSLASSHSLDIAGLELVDPLSADVHASTVISLLQSDIKTALKSAFPNLEGPLSVTDWCKGRNQLIDTGSVVDGVSAESNINECRDSSEPMSPSQSSVGGSSSIKVSNMMDKVDETSQRRSGQDLCSTESEQQTCSRLKPTLIALPFPSILVGYQDDWLKTSANSLQHWEKAPLEPYALQKPITYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQIEIESAKLSSCGFVLLDCPQSMKIESSNASLVGSVSDYFLSLSNGWDLTSYLKSLSKALRGLKIGSCFSTNPSEGSNSSCLVIYVVCPFPDPTAILQTVIESSVAIGSVVQQSDRERRSSLHSQVVKALSGLATVDEASASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVILKETSFTVYSKARRISRGISSDFAQSAFSSRSHSGLTQMPSPISGMWKDCVGPRMAGHSLPREGDIDASLRPGTWDNSWQPTRTGGLSCDPSRTGDNFLHDEIRYMFEPLFILAEPGSLENGISVIGSPTSESSKALADDSSGNYVQSTSTAGSVESASSTDASGSDPKTPPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFVQILQQGCLILQSCDPGLAKPRDFVIARIGGFYELEYLEWQKAIYSVGVSEMKRWPLQLRKSMSDGMSATSNGSSLQQSDMSLIPERTLPSSPSPLYSPHTKSPGFMKGSLGQPTARKQLIGGHSMVDNSRGLLHWAQSISFVAVSMDHTLQLVLPADSSTPGSGLPP
Length1768
PositionKinase
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.07
Grand average of hydropathy-0.245
Instability index54.65
Isoelectric point5.31
Molecular weight191484.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23620
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     675.74|     235|     273|    1148|    1420|       1
---------------------------------------------------------------------------
 1153- 1420 (328.92/257.83)	ALQK....P.ITYHVVcP...DID.PLTSAAAD.FFQQLGTVYETCKLGTHSPQGLGNQIEIESAKLsscgFVLLDcPQSMKiesSNASLVGS.VSDYFLSLSNgwDLT.SYLKSLSKAlrGlKIGSCFSTNPSeGSNSS......CLV......IYVVCPFPDPTAILqtvIESSV.AIGSVVQQSDRERRSSLHSQVVKalSG...LATVDE..ASASNILV..LSGF.SIPKLVLQivtvDAIFRVtspSVSElviLKETSFTVYskaRRISRGIS.....SDFAQSAFSSRSHSGLTQMPSP
 1423- 1695 (346.82/184.63)	GMWKdcvgPrMAGHSL.PregDIDaSLRPGTWDnSWQPTRTGGLSCDPSRTGDNFLHDEIRYMFEPL....FILAE.PGSLE...NGISVIGSpTSESSKALAD..DSSgNYVQSTSTA..G.SVESASSTDAS.GSDPKtppslhCCYgwtedwRWLVCIWTDSRGEL...LDCNIfPFGGISSRQDTKGLQCLFVQILQ..QGcliLQSCDPglAKPRDFVIarIGGFyELEYLEWQ....KAIYSV...GVSE...MKRWPLQLR...KSMSDGMSatsngSSLQQSDMSLIPERTLPSSPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.40|      24|      27|     482|     508|       3
---------------------------------------------------------------------------
  482-  508 (37.84/33.99)	DFGsMEVNNSA.ITGVGNepIGSYWDWD
  511-  535 (40.56/24.17)	DRG.MEMDIQAlLSEFGD..FGDFFEND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.97|      63|     419|     595|     694|       4
---------------------------------------------------------------------------
  595-  676 (90.53/110.24)	IEECLNKSQDNLNNSMSLGP..TNQNQLLYTREFDHIMKAEAMMTFapefgavdtptCEFSTtlfrSPYFPksrkAKSSTSSSS
 1013- 1077 (98.44/49.37)	IKTALKSAFPNLEGPLSVTDwcKGRNQLIDTGSVVDGVSAESNINE...........CRDSS....EPMSP....SQSSVGGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.62|      23|      28|     172|     194|       5
---------------------------------------------------------------------------
  172-  194 (38.97/26.26)	EFVFAATEEAIF.IHVIVSSKHIR
  202-  225 (36.65/24.25)	EKVLKHSMESTYrLPVIVSPHGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.12|      16|      34|     688|     703|       6
---------------------------------------------------------------------------
  688-  703 (28.50/19.05)	TCTEGSEGKNGKSVNT
  724-  739 (27.62/18.21)	TFVESRKEKNDKNPAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.56|      23|     407|     360|     382|       8
---------------------------------------------------------------------------
  360-  382 (45.39/28.95)	MGP.SLPGSSSFIHCA..GNVDCTED
  751-  776 (32.17/17.97)	MPPlSNIGSNAIVKSAirKTTDCTHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.70|      40|     407|     398|     474|      10
---------------------------------------------------------------------------
  427-  466 (67.34/81.07)	LEADADSLTCRQSMVSSADQLDSDGPKLGSKRSR.TGVTEL
  788-  828 (65.36/20.14)	LATDITCIMLQASMCRLRHILLSSGNLMPAGLSRsTGVSFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23620 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AESNINECRDSSEPMSPSQSSVGGSSSIKVSNMMDKVDETSQRRSGQDLCSTES
2) DPWTEINGTRTQSSYDSSSNSNNSSISSLSASSSDSDYKTTGPSELEADADSLT
1052
382
1105
435










Molecular Recognition Features






MoRF SequenceStartStop




NANANA