<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23606

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQDAYMSDFGSMEVNNSAITGVGNEPIGSYWDWGDDDRGVEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFSAPDCGDVNSSPVGVMDVSDQMLLPVGFPSFESFDPPPPAAMEECLSKSQDNLNNSMLSGPVNQTQLSYTREFDHIMKTEAMMTFAPEFGAVETPSSELSTTLFKSPYFPKSRKADSSNSSTNSYLYGAAPPSSPCIEGSEGKNGMVINSKTCSGTHDATMNLHSKNYYTYIESRKDINDKKTVTCKNDSIVKSDGMVSPPFSNIGPNAVAKSGLKMNEGTLESEHLLLSAKTLLATDVMCVMFQASMCRLRHTLLSSSNIMPLGFGRPTGVAFFNQLPGDPSTTTENISGKYEVKKKENIPVRIAGDIEGGMLDGHFNAPVGVWRTVGVSKPMKPSSSPNMEVGPSYSHNSFSDEGLLSYSQRKPLQELLDGIALLVQQAISFVDLALDVDCGDGPYGLLALQEQWRRGFCCGPSMIHAGCGGTLASSHSLDIAGVELVDPLSADVHASTVISLLQSDMKTALKSVFPHLEGPLSVTDWCKGRNQSVDTGCILDGVSAESGISECRDSSEPMSPSQSSIGGSSSIKVSNMIDGAKVEENSQRRSGQDMCSSESEQQPCPRLKPTIIALPFPSLLVGYQDDWLKTSANCLQHWEKAPLEPYGLPKPLTYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQMEIESGKLSSCGFVLLDCPQSMKIESSNASLVGSISDYFLSLSNGWDLTSYLKSLSKALRALKLGSCFSSNPSEGSNSSCMVIYVVCPFPDPSAVLQTVIESSVAIGSVIQQSDRERRSVLHSQVSKALNVSATVDETSASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVSLKETAFTVYSKARRISRGVSSDFSQSAFSSRSHSVLTQMPSPISGMWKDCVGPRMTGHSIPREGDIDASLRTGTWDNSWQPTRTGGLSCDPSRSGGHFLQDETRYMFEPLFILAEPGSVEHGVSAVGSPNSDSSKTMADDGSGNYMQNTTGSADSASSIDGSGSDQKTLPSLHCCYGWTEDWRWLVCIWTDSRGELLDSNIFPFGGISGRQDTKGLQCLFVQVLQQGCLILQSCDTGLAKPRDFVIARIGGFFELEYLEWQKAIYSVVGSEMKKWPMQLRKSMSDGLSATSNGSSLQQPEMSMIPERALPSSPSPLYSPHAKPTGFMKGSLGQPAARKQLMAGHMVDNSRGLLHWAQSISFVSVSMDHTLQLVLPADSSPGYIEGFTPVKSLGSASSAYILIPSPSMRFLPPTTLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLSVSLIDYYGGTNIPQEKILRGINKQGGRIPSWEAKDFEIETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1475
PositionKinase
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index53.80
Isoelectric point5.19
Molecular weight159562.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23606
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     228.10|      50|      53|      29|      78|       1
---------------------------------------------------------------------------
    4-   44 (60.22/35.18)	.AYMSDFGSM.EVNNSAITGVGnEPIG..........sYWDWGDDDR...GVEMDI
   45-   97 (82.27/51.51)	QALLSEFGDFGDFFENDVLPFG.EPPGTAESQALMfS.APDCGDVNSspvGV.MDV
  100-  125 (37.37/18.27)	QMLLP.VG.FPS.FES....FD.PPPPAAMEECL......................
 1019- 1052 (48.23/26.31)	...LAEPGSV....EHGVSAVG.SP..NSDSSKTM.A......DDGS...GNYM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.76|      24|      28|     185|     208|       2
---------------------------------------------------------------------------
  185-  208 (43.17/21.71)	SPYFPKSRKADSS..NSSTNSYLYGA
  213-  238 (40.59/19.98)	SPCIEGSEGKNGMviNSKTCSGTHDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.99|      40|     122|     650|     697|       3
---------------------------------------------------------------------------
  638-  681 (59.10/29.25)	..........CPRLKP.........tiialpFPSLLVG.YQ.DDWLKT.SANCLQH......W...EKAPLEPYG
  682-  741 (45.88/36.85)	LPkpltyhvvCPDIDP.......ltsaaadfFQQLGTV.YE.TCKLGThSPQGLGN......QmeiESGKLSSCG
  745-  806 (44.91/21.89)	LD........CPQSMKiessnaslvgsisdyFLSLSNG.WDlTSYLKS.LSKALRAlklgscF...SSNPSEGSN
  975- 1000 (29.09/ 9.13)	.................................SLRTGtWD.NSWQPT.RTGGL............SCDPSRS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.11|      40|      68|    1190|    1229|       4
---------------------------------------------------------------------------
 1190- 1229 (71.18/41.02)	SDGLSATSNGSSLQQPEMSMIPERALPSSPSPLYSPHAKP
 1255- 1294 (70.93/40.85)	SRGLLHWAQSISFVSVSMDHTLQLVLPADSSPGYIEGFTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.05|      28|      68|     424|     453|       5
---------------------------------------------------------------------------
  424-  453 (45.97/34.31)	GPSYSHNSFSdeGLLSYSQRKPLQ..ELLDGI
  493-  522 (46.08/27.76)	GPSMIHAGCG..GTLASSHSLDIAgvELVDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.36|      51|      59|     812|     864|       6
---------------------------------------------------------------------------
  809-  861 (83.56/74.61)	CMV.......IYVVCPFPDPSAVLQTVIESsvAIGSVIQQSDRERRSVLHSQ...VSKALNVS
  862-  922 (69.80/54.67)	ATVdetsasnILVLSGFSIPKLVLQIVTVD..AIFRVTSPSVSELVSLKETAftvYSKARRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.56|      29|     823|     529|     564|      17
---------------------------------------------------------------------------
  535-  564 (47.63/35.64)	LQSDMKTALKSVFPHLEGpLSVTDWCKGRN
 1360- 1388 (51.93/23.36)	MRKDYRSNLKEEWPSVLS.VSLIDYYGGTN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23606 with Med13 domain of Kingdom Viridiplantae
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