<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23605

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSHILIAAIWPVTQPLEAHEVEALAVYLGMKLAKKCCFMKIVVESDYMEVGGLHQLSWFQFLPNDPDPCFLPDKSNKVDQKDAAMLAVISSHLQLQKEGFLSAWTNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVIETAQSAVSGLRAPGDVEEVAAALSQALRNCIERALNGLYYMRFGEVFSKFHHFQSEELFRKGQPTVEFVFAATEEAIFVHVIVSSKHIRMLSSGDLEKVLKHSMEAKYRLPVIVSPHGIRGSLVGSSPSDLVKQSYFSSSSKFRASSGIIGLPNHVSQGVGCQLRGQNCYVEVSLGFPRLGTDKALQSNKNSVRNLSKLHVAESPAAGRSDHKGSPDHLSDCEKTFLYPAEAVLVPVLQTSLARSSLRRQSVVSSGDQLESDGPKLGSKRSRAGVTESLSTATNVPMQDAYMSDFGSMEVNNSAITGVGNEPIGSYWDWGDDDRGVEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFSAPDCGDVNSSPVGVMDVSDQMLLPVGFPSFESFDPPPPAAMEECLSKSQDNLNNSMLSGPVNQTQLSYTREFDHIMKTEAMMTFAPEFGAVETPSSELSTTLFKSPYFPKSRKADSSNSSTNSYLYGAAPPSSPCIEGSEGKNGMVINSKTCSGTHDATMNLHSKNYYTYIESRKDINDKKTVTCKNDSIVKSDGMVSPPFSNIGPNAVAKSGLKMNEGTLESEHLLLSAKTLLATDVMCVMFQASMCRLRHTLLSSSNIMPLGFGRPTGVAFFNQLPGDPSTTTENISGKYEVKKKENIPVRIAGDIEGGMLDGHFNAPVGVWRTVGVSKPMKPSSSPNMEVGPSYSHNSFSDEGLLSYSQRKPLQELLDGIALLVQQAISFVDLALDVDCGDGPYGLLALQEQWRRGFCCGPSMIHAGCGGTLASSHSLDIAGVELVDPLSADVHASTVISLLQSDMKTALKSVFPHLEGPLSVTDWCKGRNQSVDTGCILDGVSAESGISECRDSSEPMSPSQSSIGGSSSIKVSNMIDGAKVEENSQRRSGQDMCSSESEQQPCPRLKPTIIALPFPSLLVGYQDDWLKTSANCLQHWEKAPLEPYGLPKPLTYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQMEIESGKLSSCGFVLLDCPQSMKIESSNASLVGSISDYFLSLSNGWDLTSYLKSLSKALRALKLGSCFSSNPSEGSNSSCMVIYVVCPFPDPSAVLQTVIESSVAIGSVIQQSDRERRSVLHSQVSKALNVSATVDETSASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVSLKETAFTVYSKARRISRGVSSDFSQSAFSSRSHSVLTQMPSPISGMWKDCVGPRMTGHSIPREGDIDASLRTGTWDNSWQPTRTGGLSCDPSRSGGHFLQDETRYMFEPLFILAEPGSVEHGVSAVGSPNSDSSKTMADDGSGNYMQNTTGSADSASSIDGSGSDQKTLPSLHCCYGWTEDWRWLVCIWTDSRGELLDSNIFPFGGISGRQDTKGLQCLFVQVLQQGCLILQSCDTGLAKPRDFVIARIGGFFELEYLEWQKAIYSVVGSEMKKWPMQLRKSMSDGLSATSNGSSLQQPEMSMIPERALPSSPSPLYSPHAKPTGFMKGSLGQPAARKQLMAGHMVDNSRGLLHWAQSISFVSVSMDHTLQLVLPADSSPGYIEGFTPVKSLGSASSAYILIPSPSMRFLPPTTLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLSVSLIDYYGGTNIPQEKILRGINKQGGRIPSWEAKDFEIETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1900
PositionKinase
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.07
Grand average of hydropathy-0.202
Instability index53.44
Isoelectric point5.62
Molecular weight206068.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     563.85|     183|     228|     783|    1010|       1
---------------------------------------------------------------------------
  710-  869 (192.40/104.78)	................................................GPN...AV.AKSGlkmneGTL...................ESEH.........................LLLS.AKTLLAT...DVMCVMFQASMCRLRHT...LLSSSNIMPlGFGRPTGVAFF..nqlPGDPSTTTenISGKYEVKkkenipvrIAGDIEGGMLDGHFNAPVG..VWRTVGVSKP...MKPS....SSPNMEVGpsYSHNSF.SDEGLLSYSQRK
  870- 1100 (267.64/174.27)	PLQelldgiallvqqaisfvdlaldvdcgdgPYGllaLQEQWRRGFCCGPS...MIHAGCG.....GTL...................ASSHSLDIAGVELVD.PLSADVHASTViSLLQSdMKTALKSVFPHLEGPLSVTDWCKGRNQ...SVDTGCILD.GVSAESGISECrdssePMSPSQSS..IGGSSSIK........VSNMIDGAKVEENSQRRSGqdMCSSESEQQPcprLKPTiialPFPSLLVG..YQDDWLkTSANCLQHWEKA
 1101- 1234 (103.82/43.06)	PLE............................PYG...LPKPLTYHVVC.PDidpLTSAAADffqqlGTVyetcklgthspqglgnqmeIESGKLSSCGFVLLDcPQSMKIESSNA.SLVGS.....ISDYFLSLSNGWDLTSYLKSLSKalrALKLGSCFS.SNPSEGSNSSC......................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.21|      23|      28|     206|     228|       2
---------------------------------------------------------------------------
  206-  228 (39.33/25.42)	EFVFAATEEAIF.VHVIVSSKHIR
  236-  259 (36.89/23.38)	EKVLKHSMEAKYrLPVIVSPHGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.69|      10|      23|     453|     462|       3
---------------------------------------------------------------------------
  453-  462 (22.82/13.15)	GSYWDWGDDD
  477-  486 (19.88/10.40)	GDFGDFFEND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.62|      13|      25|    1376|    1400|       4
---------------------------------------------------------------------------
 1376- 1388 (28.46/31.57)	GMWKDCVGPRMTG
 1404- 1416 (28.17/ 6.98)	GTWDNSWQPTRTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.76|      14|      24|     507|     520|       5
---------------------------------------------------------------------------
  507-  520 (23.54/10.90)	PDCGDVNSSPVGVM
  533-  546 (27.02/13.79)	PSFESFDPPPPAAM
 1736- 1748 (21.20/ 8.96)	PSMR.FLPPTTLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.92|      22|      29|     383|     407|       6
---------------------------------------------------------------------------
  383-  407 (31.54/23.12)	RS....SLRRQSVVSSGDQLESDgpkLGS
  411-  436 (33.38/16.23)	RAgvteSLSTATNVPMQDAYMSD...FGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     246.34|      66|    1208|     261|     326|       7
---------------------------------------------------------------------------
  261-  326 (119.55/62.49)	SLVGSSPSDLVKQ...............SYFSSSSKFRASSGIIGLPN.HVSQGVGCQLRGQNCYVEVSLG.......FPRLGTD.....KALQ
 1349- 1375 (27.28/ 8.29)	...GVS.SDF.SQ...............SAFSS....RSHSVLTQMPS.PIS..........................................
 1455- 1548 (99.51/50.72)	SAVGSPNSDSSKTmaddgsgnymqnttgSADSASSIDGSGSDQKTLPSlHCCYGWTEDWRWLVCIWTDSRGelldsniFPFGGISgrqdtKGLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23605 with Med13 domain of Kingdom Viridiplantae
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