<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23604

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQLSWFQFLPNDPDPCFLPDKSNKVDQKDAAMLAVISSHLQLQKEGFLSAWTNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVIETAQSAVSGLRVVASGLWLAPGDVEEVAAALSQALRNCIERALNGLYYMRFGEVFSKFHHFQSEELFRKGQPTVEFVFAATEEAIFVHVIVSSKHIRMLSSGDLEKVLKHSMEAKYRLPVIVSPHGIRGSLVGSSPSDLVKQSYFSSSSKFRASSGIIGLPNHVSQGVGCQLRGQNCYVEVSLGFPRLGTDKALQSNKNSVRNLSKLHVAESPAAGRSDHKGSPDHLSDCEKTFLYPAEAVLVPVLQTSLARSSLRRFWLQNWMGPSLPGSSSFIHCAANVDSIEDPWAEINGSRMQNSYDSSSNSNSSSISSISASSSDSDYKTTGPNELEADADSLTCRQSVVSSGDQLESDGPKLGSKRSRAGVTESLSTATNVPMQDAYMSDFGSMEVNNSAITGVGNEPIGSYWDWGDDDRGVEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFSAPDCGDVNSSPVGVMDVSDQMLLPVGFPSFESFDPPPPAAMEECLSKSQDNLNNSMLSGPVNQTQLSYTREFDHIMKTEAMMTFAPEFGAVETPSSELSTTLFKSPYFPKSRKADSSNSSTNSYLYGAAPPSSPCIEGSEGKNGMVINSKTCSGTHDATMNLHSKNYYTYIESRKDINDKKTVTCKNDSIVKSDGMVSPPFSNIGPNAVAKSGLKMNEGTLESEHLLLSAKTLLATDVMCVMFQASMCRLRHTLLSSSNIMPLGFGRPTGVAFFNQLPGDPSTTTENISGKYEVKKKENIPVRIAGDIEGGMLDGHFNAPVGVWRTVGVSKPMKPSSSPNMEVGPSYSHNSFSDEGLLSYSQRKPLQELLDGIALLVQQAISFVDLALDVDCGDGPYGLLALQEQWRRGFCCGPSMIHAGCGGTLASSHSLDIAGVELVDPLSADVHASTVISLLQSDMKTALKSVFPHLEGPLSVTDWCKGRNQSVDTGCILDGVSAESGISECRDSSEPMSPSQSSIGGSSSIKVSNMIDGAKVEENSQRRSGQDMCSSESEQQPCPRLKPTIIALPFPSLLVGYQDDWLKTSANCLQHWEKAPLEPYGLPKPLTYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQMEIESGKLSSCGFVLLDCPQSMKIESSNASLVGSISDYFLSLSNGWDLTSYLKSLSKALRALKLGSCFSSNPSEGSNSSCMVIYVVCPFPDPSAVLQTVIESSVAIGSVIQQSDRERRSVLHSQVSKALNVSATVDETSASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVSLKETAFTVYSKARRISRGVSSDFSQSAFSSRSHSVLTQMPSPISGMWKDCVGPRMTGHSIPREGDIDASLRTGTWDNSWQPTRTGGLSCDPSRSGGHFLQDETRYMFEPLFILAEPGSVEHGVSAVGSPNSDSSKTMADDGSGNYMQNTTGSADSASSIDGSGSDQKTLPSLHCCYGWTEDWRWLVCIWTDSRGELLDSNIFPFGGISGRQDTKGLQCLFVQVLQQGCLILQSCDTGLAKPRDFVIARIGGFFELEYLEWQKAIYSVVGSEMKKWPMQLRKSMSDGLSATSNGSSLQQPEMSMIPERALPSSPSPLYSPHAKPTGFMKGSLGQPAARKQLMAGHMVDNSRGLLHWAQSISFVSVSMDHTLQLVLPADSSPGYIEGFTPVKSLGSASSAYILIPSPSMRFLPPTTLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLSVSLIDYYGGTNIPQEKILRGINKQGGRIPSWEAKDFEIETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1950
PositionKinase
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.07
Grand average of hydropathy-0.230
Instability index53.58
Isoelectric point5.49
Molecular weight211264.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.96|      38|     122|    1125|    1172|       1
---------------------------------------------------------------------------
 1129- 1172 (67.25/61.40)	LVGYQDDWLKTSANclqHWEkapLEPY..GLPKPLT......................YHVVCPDIDP
 1235- 1296 (54.71/26.73)	LVGSISDYFLSLSN...GWD...LTSYlkSLSKALRalklgscfssnpsegsnsscmvIYVVCPFPDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.03|      21|      26|    1495|    1515|       2
---------------------------------------------------------------------------
 1495- 1515 (37.35/20.18)	AEPGSVEHGVSAVGSPNSDSS
 1519- 1539 (37.68/20.43)	ADDGSGNYMQNTTGSADSASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.62|      13|      26|    1426|    1438|       3
---------------------------------------------------------------------------
 1426- 1438 (28.46/15.86)	GMWKDCVGPRMTG
 1454- 1466 (28.17/15.63)	GTWDNSWQPTRTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.39|      14|      24|     780|     798|       4
---------------------------------------------------------------------------
  780-  798 (20.38/19.26)	HLLLSaktllATDVMCVMF
  807-  820 (26.00/12.99)	HTLLS.....SSNIMPLGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.67|      19|      28|     520|     541|       5
---------------------------------------------------------------------------
  520-  541 (30.61/20.56)	QALLSEFGDFGDFFENdvlPFG
  550-  568 (35.06/16.43)	QALMFSAPDCGDVNSS...PVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.21|      23|      28|     172|     194|       6
---------------------------------------------------------------------------
  172-  194 (39.33/25.94)	EFVFAATEEAIF.VHVIVSSKHIR
  202-  225 (36.89/23.88)	EKVLKHSMEAKYrLPVIVSPHGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.99|      17|      22|    1376|    1396|       7
---------------------------------------------------------------------------
 1370- 1387 (23.20/18.29)	RVTSP...SVSElVS..LKETAF
 1388- 1409 (18.79/18.40)	TVYSKarrISRG.VSsdFSQSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.11|      22|      22|    1050|    1071|       8
---------------------------------------------------------------------------
 1050- 1071 (39.28/21.55)	GVSAESGISEC...........RDSSEPMSPSQ
 1075- 1107 (30.83/15.18)	GGSSSIKVSNMidgakveensqRRSGQDMCSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.68|      16|      28|     929|     956|       9
---------------------------------------------------------------------------
  370-  385 (31.97/ 8.92)	SFIHCAANVDSIEDPW
  937-  952 (30.71/13.81)	SFVDLALDVDCGDGPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.68|      20|      24|     464|     485|      10
---------------------------------------------------------------------------
  464-  485 (26.80/24.70)	VTES.LSTATNVPMqDAYMsDFG
  489-  509 (33.88/20.19)	VNNSaITGVGNEPI.GSYW.DWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.17|      59|     828|      16|      79|      11
---------------------------------------------------------------------------
   16-   79 (97.98/75.60)	WFQFLPNDPDPCfLPDKSNKVDQKDAAMLAV.ISSHLQlqkEGFLSAWTNSFVGPWDpSQGLHNP
  828-  887 (102.18/62.08)	FFNQLPGDPSTT.TENISGKYEVKKKENIPVrIAGDIE...GGMLDGHFNAPVGVWR.TVGVSKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.76|      24|      28|     660|     683|      12
---------------------------------------------------------------------------
  660-  683 (43.17/26.45)	SPYFPKSRKADSS..NSSTNSYLYGA
  688-  713 (40.59/24.34)	SPCIEGSEGKNGMviNSKTCSGTHDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.16|      53|     827|     984|    1039|      14
---------------------------------------------------------------------------
  984- 1039 (80.75/48.27)	HSLDIAGVELvdPLSADVHASTVISLLQSDMKTALKSVFPHLEGpLSVTDWCKGRN
 1811- 1863 (92.41/46.15)	HLLHSKGSAL..PLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLS.VSLIDYYGGTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.48|      28|     422|    1181|    1208|      16
---------------------------------------------------------------------------
 1181- 1208 (51.10/28.97)	FQQLGTVYETCKLGTHSPQG.....LGNQMEIE
 1605- 1637 (44.37/24.20)	LQQGCLILQSCDTGLAKPRDfviarIGGFFELE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23604 with Med13 domain of Kingdom Viridiplantae
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